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Cat. No.: HY-N2099A

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(Z)-Onjisaponin B

(Synonyms: (Z)-Senegin III)

(Z)-Onjisaponin B ((Z)-Senegin III) is a derivative of Onjisaponin B (HY-N2099). Onjisaponin B is an orally active natural product derived from Polygala tenuifolia. Onjisaponin B inhibits NF-κB p65. Onjisaponin B enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin. Onjisaponin B reduces β-amyloid (Aβ) production. Onjisaponin B reduces radiation-induced cell apoptosis. Onjisaponin B has anti-oxidant and anti-inflammatory activities. Onjisaponin B can be used for neurological disease and radiation injury study, and its metabolite tenuifolin (TF) can enter the brain through the BBB.

For research use only. We do not sell to patients.

CAS No.: 162681-53-0
Formula: C₇₅H₁₁₂O₃₅
Molecular Weight:1573.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

(Z)-Onjisaponin B Chemical Structure

CAS No.: 162681-53-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

CAS No. 162681-53-0
Molecular Weight 1573.67
Formula C₇₅H₁₁₂O₃₅
SMILES

OC[C@]12[C@]3([C@@](CC=C1[C@@]4([H])[C@@](CC2)(CCC(C)(C4)C)C(O[C@H]5[C@@H]([C@H]([C@H]([C@H](O5)C)OC(/C=C\C6=CC=C(C=C6)OC)=O)O[C@H]7[C@@H]([C@@H]([C@H]([C@@H](O7)C)O)O)O)O[C@H]8[C@@H]([C@@H]([C@H]([C@@H](O8)C)O[C@H]9[C@@H]([C@H]([C@@H](CO9)O[C@@H]%10O[C@@H]([C@@H]([C@@H]([C@H]%10O)O)O)CO)O)O)O)O)=O)([H])[C@@]%11([C@@]([C@@](C)([C@H]([C@H](C%11)O)O[C@@H]%12O[C@@H]([C@H]([C@@H]([C@H]%12O)O)O)CO)C(O)=O)([H])CC3)C)C
Synonyms

(Z)-Senegin III
Structure Classification
- Terpenoids
- Triterpenes
- Terpenoids
- Pentacyclic Triterpenoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. YOSHIKAWA, et al. E-Senegasaponins A and B, Z-Senegasaponins A and B, Z-Senegins II and III, New Type Inhibitors of Ethanol Absorption in Rats from Senegae Radix, the Roots of Polygala senega L. var Latifolia TORREY et GRAY. . Chem Pharm Bull (Tokyo). 1995 Feb;43(2):350-2. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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