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Cat. No.: HY-184215

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Z2768276635

Z2768276635 is an Arabidopsis thaliana acetohydroxyacid synthase (AHAS) inhibitor with a K_i of 0.12 μM, and a K_d of 0.565 μM.Z2768276635 forms a covalent bond with the Ser653 residue of AtAHAS to inhibit catalytic activity.Z2768276635 can be used for the research of weed herbicide resistance.

For research use only. We do not sell to patients.

CAS No.: 2920564-49-2
Formula: C₂₀H₂₁FN₂O₅S
Molecular Weight:420.45

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Please store the product under the recommended conditions in the Certificate of Analysis.

Z2768276635 Chemical Structure

CAS No.: 2920564-49-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Z2768276635 (1 h) potently inhibits Arabidopsis thaliana AHAS (AHAS) with a K_i of 0.12 μM^[1].
Z2768276635 binds strongly to wild-type Arabidopsis thaliana AHAS (WT-AtAHAS) with a binding constant of 10^4.396, and binding affinity is significantly reduced for Ser653-to-Thr mutant AtAHAS^S653T (MutS653T-AtAHAS), demonstrating Ser653 is critical for high-affinity binding^[1].
Z2768276635 binds to wild-type Arabidopsis thaliana AHAS (WT-AtAHAS) with a dissociation constant of 0.565 μM, and binding affinity is weaker for Ser653-to-Thr mutant AtAHAS^S653T (MutS653T-AtAHAS), confirming Ser653 is critical for high-affinity binding^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2920564-49-2
Molecular Weight 420.45
Formula C₂₀H₂₁FN₂O₅S
SMILES

O=S(C1=CC=CC(C(NCC2=CC=CC(C(NCC3OCCC3)=O)=C2)=O)=C1)(F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhong F, et al. Discovery of Potential Acetohydroxyacid Synthase Covalent Inhibitors with Integrated Virtual Screening Approach. J Agric Food Chem. 2026;74(21):16074-16086. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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