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Cat. No.: HY-W987949

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Z-4105

Z-4105 is an orally active nootropic agent. Z-4105 reverses the amnesic effects of electroconvulsive shock (ECS) and methylazoxymethanol acetate (MAM), and improves learning and memory functions. Z-4105 enhances the activity of the brain cholinergic system without affecting other neurotransmitter systems. Z-4105 significantly alleviates neuropathic pain in rats. Z-4105 can be used in the research of neuropathic pain and brain dysfunction.

For research use only. We do not sell to patients.

CAS No.: 119737-52-9
Formula: C₉H₁₂N₂O₄
Molecular Weight:212.20

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Z-4105 Chemical Structure

CAS No.: 119737-52-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Bioz

Biological Activity

Description

In Vivo

Z-4105 (3-300 mg/kg; p.o.; single administration) produces a dose-dependent alleviating effect on mechanical hyperalgesia in a rat model of neuropathic pain^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar (male, chronic constrictive injury of the sciatic nerve model); Wistar (male, spinal nerve ligation model)^[1]
Dosage:

3 mg/kg; 30 mg/kg; 300 mg/kg
Administration:

p.o.; single dose
Result:

Reduced mechanical allodynia in a dose-dependent manner.
Produced statistically significant antiallodinic effect starting at 3 mg/kg, which persisted up to 6 hours post-treatment.
Reduced mechanical allodynia in a dose-dependent manner.
Produced statistically significant antiallodinic effect starting at 3 mg/kg, which persisted up to 6 hours post-treatment.

Chemical Information

CAS No. 119737-52-9
Molecular Weight 212.20
Formula C₉H₁₂N₂O₄
SMILES

O=C(CCCNC(C1=CC(C)=NO1)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ricciardi S, et al. BEHAVIORAL AND BIOCHEMICAL EFFECTS OF A NEW POTENTIAL NOOTROPIC AGENT-Z4105[J]. JOURNAL OF DRUG DEVELOPMENT, 1994, 6(4): 159-170.

[2]. Mauro Napoletano, et al. Isoxazolic derivative to relieve neuropathic pain. WO2006053860A1.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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