CYP4Z1-IN-1
CYP4Z1-IN-1 (compound 7c) is a potent CYP4Z1 inhibitor, with an IC50 of 41.8 nM. CYP4Z1-IN-1 decreases the expression of breast CSCs stemness markers, spheroid formation, and metastatic ability as well as tumor-initiation capability in a concentration-dependent manner in vitro and in vivo.
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- CAS No.: 2760611-38-7
- Formule: C13H18N2O3
- Masse moléculaire:250.29
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
Description
IC50 & Target
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CYP4Z1 41.8 ± 1.4 nM (IC50) |
CYP4F11 291.3 ± 46 nM (IC50) |
CYP4F12 1598.3 ± 5 nM (IC50) |
CYP2D6 >10 000 nM (IC50) |
CYP2C9 >10 000 nM (IC50) |
CYP3A4 >10 000 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| MCF7 | IC50 |
483 nM
Compound: 7c
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Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
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[PMID: 36414390] |
| MDA-MB-231 | IC50 |
483 nM
Compound: 7c
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Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
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[PMID: 36414390] |
In Vitro
CYP4Z1-IN-1 (compound 7c) shows antiproliferative activity against breast CSCs (cancer stem cells), with an IC50 of 483 ± 2.5 nM[1].
CYP4Z1-IN-1 (0.8-51.2 μM, 24 h) suppresses the expression of stemness markers (P-gp, Oct3/4, Nanog, ALDH1A1, and Sox2) in breast cancer cells[1].
CYP4Z1-IN-1 (0.8-51.2 μM, 24-48 h) attenuates the migration and invasion ability of breast cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 and MDA-MB-231 cells
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Concentration:0.8 μM, 3.2 μM, 12.8 μM, 51.2 μM
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Incubation Time:24 h
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Result:Significantly suppressed the protein expression of stemness markers (P-gp, Oct3/4, Nanog, ALDH1A1, and Sox2) in MCF-7 cells in a concentration-dependent manner.
In Vivo
CYP4Z1-IN-1 (MCF-7 and MDA-MB-231 cells (12.8 μM, 72 h) implanted in the inguinal mammary gland of mice subcutaneously) blocks the tumor-initiating ability of breast cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice[1]
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Dosage:2000 mg/kg
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Administration:orally, for 7 days
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Result:Showed that compound 7c was rather safe; no evident toxicity and body weight loss were observed.
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Animal Model:BALB/c-nude mice (3-4 week old, female)[1]
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Dosage:12.8 μM
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Administration:MCF-7 and MDA-MB-231 cells were pre-treated with 7c (12.8 μM) for 72 h and were then implanted in the inguinal mammary gland of mice subcutaneously
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Result:Blocked the tumor-initiating ability of breast cancer cells.
Chemical Information
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CAS No. 2760611-38-7
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Masse moléculaire 250.29
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Formule C13H18N2O3
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SMILES
O=C(CCCC1=CC=C(C=C1)N/C=N/O)OCC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CYP4Z1-IN-1 Related Classifications
HY-152159 Related Classifications
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