(E/Z)-Demethoxycurcumin
Based on 1 Customer Validation
(E/Z)-Demethoxycurcumin (p-Hydroxycinnamoyl-feruloylmethane) is a curcuminoid isolated from curcuma species, with anticoagulative active.
For research use only. We do not sell to patients.
- Purity: 99.79%
- CAS No.: 24939-17-1
- Formula: C20H18O5
- Molecular Weight:338.35
-
Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
>100 μM
Compound: DC
|
Cytotoxicity against human A431 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
Cytotoxicity against human A431 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
|
[PMID: 29605808] |
| A549 | IC50 |
28.2 μM
Compound: DC
|
Cytotoxicity against human A549 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
Cytotoxicity against human A549 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
|
[PMID: 29605808] |
| DLD-1 | IC50 |
>40 μM
Compound: DC
|
Cytotoxicity against human DLD1 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
Cytotoxicity against human DLD1 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
|
[PMID: 29605808] |
| HT-1080 | IC50 |
7.5 μM
Compound: DMC
|
Decrease in UPA expression in human HT1080 cells
Decrease in UPA expression in human HT1080 cells
|
[PMID: 31336310] |
| MCF7 | IC50 |
92.1 μM
Compound: DC
|
Cytotoxicity against human MCF7 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
|
[PMID: 29605808] |
| MDA-MB-231 | IC50 |
9 mM
Compound: DMC
|
Increase in MMP3 level in human MDA-MB-231 cells after 24 hrs by ELISA
Increase in MMP3 level in human MDA-MB-231 cells after 24 hrs by ELISA
|
[PMID: 31336310] |
| WRL68 | IC50 |
26.3 μM
Compound: DC
|
Cytotoxicity against human WRL68 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
Cytotoxicity against human WRL68 cells preincubated for 4 hrs followed by incubation in compound free media for 24 hrs by MTT assay
|
[PMID: 29605808] |
Chemical Information
-
CAS No. 24939-17-1
-
Appearance Solid
-
Molecular Weight 338.35
-
Formula C20H18O5
-
Color Yellow to orange
-
SMILES
O=C(CC(/C=C/C1=CC=C(O)C=C1)=O)/C=C/C2=CC=C(O)C(OC)=C2
-
Synonyms
p-Hydroxycinnamoyl-feruloylmethane
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (295.55 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (266 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9555 mL | 14.7776 mL | 29.5552 mL | 73.8880 mL |
| 5 mM | 0.5911 mL | 2.9555 mL | 5.9110 mL | 14.7776 mL | |
| 10 mM | 0.2956 mL | 1.4778 mL | 2.9555 mL | 7.3888 mL | |
| 15 mM | 0.1970 mL | 0.9852 mL | 1.9703 mL | 4.9259 mL | |
| 20 mM | 0.1478 mL | 0.7389 mL | 1.4778 mL | 3.6944 mL | |
| 25 mM | 0.1182 mL | 0.5911 mL | 1.1822 mL | 2.9555 mL | |
| 30 mM | 0.0985 mL | 0.4926 mL | 0.9852 mL | 2.4629 mL | |
| 40 mM | 0.0739 mL | 0.3694 mL | 0.7389 mL | 1.8472 mL | |
| 50 mM | 0.0591 mL | 0.2956 mL | 0.5911 mL | 1.4778 mL | |
| 60 mM | 0.0493 mL | 0.2463 mL | 0.4926 mL | 1.2315 mL | |
| 80 mM | 0.0369 mL | 0.1847 mL | 0.3694 mL | 0.9236 mL | |
| 100 mM | 0.0296 mL | 0.1478 mL | 0.2956 mL | 0.7389 mL |