1. Others
    Metabolic Enzyme/Protease
    Immunology/Inflammation
    NF-κB
  2. Estrogen Receptor/ERR
    Reactive Oxygen Species
  3. (E/Z)-GSK5182

(E/Z)-GSK5182 

Cat. No.: HY-111226A Purity: 98.90%
Handling Instructions

(E/Z)-GSK5182 is a racemic compound of (E)-GSK5182 and (Z)-GSK5182 isomers. GSK5182 is a highly selective and orally active inverse agonist of estrogen-related receptor γ (ERRγ) with an IC50 of 79 nM. GSK5182 also induces reactive oxyen species (ROS) generation in hepatocellular carcinoma.

For research use only. We do not sell to patients.

(E/Z)-GSK5182 Chemical Structure

(E/Z)-GSK5182 Chemical Structure

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 308 In-stock
Estimated Time of Arrival: December 31
5 mg USD 280 In-stock
Estimated Time of Arrival: December 31
10 mg USD 450 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (E/Z)-GSK5182:

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Description

(E/Z)-GSK5182 is a racemic compound of (E)-GSK5182 and (Z)-GSK5182 isomers. GSK5182 is a highly selective and orally active inverse agonist of estrogen-related receptor γ (ERRγ) with an IC50 of 79 nM[1]. GSK5182 also induces reactive oxyen species (ROS) generation in hepatocellular carcinoma[1][2][3].

Molecular Weight

417.54

Formula

C₂₇H₃₁NO₃

SMILES

OCCC/C(C1=CC=CC=C1)=C(C2=CC=C(C=C2)OCCN(C)C)\C3=CC=C(C=C3)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (239.50 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3950 mL 11.9749 mL 23.9498 mL
5 mM 0.4790 mL 2.3950 mL 4.7900 mL
10 mM 0.2395 mL 1.1975 mL 2.3950 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 98.90%

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Keywords:

(E/Z)-GSK5182Estrogen Receptor/ERRReactive Oxygen Species(E)-GSK5182(Z)-GSK5182isomersERRγROSInhibitorinhibitorinhibit

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Product name:
(E/Z)-GSK5182
Cat. No.:
HY-111226A
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