2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species (ROS)
  4. Z226407860

Z226407860 is a RING-box protein 1 (RBX1) inhibitor. Z226407860 reduces house dust mite-induced airway epithelial injury and ROS accumulation by inhibiting RBX1. Z226407860 can be used for the research of asthma.

For research use only. We do not sell to patients.

Z226407860

Z226407860 Chemical Structure

CAS No. : 2419496-02-7

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Z226407860 Related Antibodies

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Description

Z226407860 is a RING-box protein 1 (RBX1) inhibitor. Z226407860 reduces house dust mite-induced airway epithelial injury and ROS accumulation by inhibiting RBX1. Z226407860 can be used for the research of asthma[1].

In Vitro

Z226407860 (5 μM) potently inhibits the expression of RBX1 mRNA and protein in normal HBE cells, and suppresses HDM-induced overexpression of RBX1 protein in HBE cells[1].
Z226407860 (5 μM) alleviates HDM-induced epithelial barrier dysfunction in HBE cells by restoring the levels of Occludin and E-cadherin, and reduces the accumulation of reactive oxygen species (ROS) in cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Z226407860 Related Antibodies
Molecular Weight

540.67

Formula

C28H36N4O5S
CAS No.
SMILES

OC1=CC=C(CCC2CCN(C(CCC3=NC(C=C(S(N4CCOCC4)(=O)=O)C=C5)=C5N3C)=O)CC2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Z226407860 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z2264078602419496-02-7Z 226407860Z-226407860Reactive Oxygen Species (ROS)RBX1 InhibitorasthmaHBE cellsInhibitorinhibitorinhibit

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