Z226407860
Z226407860 is a RING-box protein 1 (RBX1) inhibitor. Z226407860 reduces house dust mite-induced airway epithelial injury and ROS accumulation by inhibiting RBX1. Z226407860 can be used for the research of asthma.
For research use only. We do not sell to patients.
- CAS No.: 2419496-02-7
- Formula: C28H36N4O5S
- Molecular Weight:540.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Z226407860 (5 μM) potently inhibits the expression of RBX1 mRNA and protein in normal HBE cells, and suppresses HDM-induced overexpression of RBX1 protein in HBE cells[1].
Z226407860 (5 μM) alleviates HDM-induced epithelial barrier dysfunction in HBE cells by restoring the levels of Occludin and E-cadherin, and reduces the accumulation of reactive oxygen species (ROS) in cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2419496-02-7
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Molecular Weight 540.67
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Formula C28H36N4O5S
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SMILES
OC1=CC=C(CCC2CCN(C(CCC3=NC(C=C(S(N4CCOCC4)(=O)=O)C=C5)=C5N3C)=O)CC2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Z226407860 Related Classifications
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