country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-N1067A

Copy Link Print Information

(E/Z)-Xanthohumol

(E/Z)-Xanthohumol is a flavonoid isolated from hopfen.

For research use only. We do not sell to patients.

CAS No.: 569-83-5
Formula: C₂₁H₂₂O₅
Molecular Weight:354.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

(E/Z)-Xanthohumol Chemical Structure

CAS No.: 569-83-5

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

(E/Z)-Xanthohumol is a flavonoid isolated from hopfen^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	11.9 μM Compound: Xn	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 30196062]
A549	IC₅₀	30.5 μM Compound: 8a, Xn	Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay	[PMID: 25629304]
BGC-823	IC₅₀	7.8 μM Compound: Xanthohumol	Cytotoxicity against human BGC823 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human BGC823 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 29288946]
BV-2	IC₅₀	7.92 μM Compound: 14	Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by griess assay Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by griess assay	[PMID: 29154541]
HEK293	IC₅₀	35 μM Compound: 1	Inhibition of TNF-alpha-induced NF-kappaB activation expressed in human HEK293 cells preincubated for 2 hrs before TNFalpha challenge by leuciferase reporter gene assay Inhibition of TNF-alpha-induced NF-kappaB activation expressed in human HEK293 cells preincubated for 2 hrs before TNFalpha challenge by leuciferase reporter gene assay	[PMID: 19757857]
HeLa	IC₅₀	>40 μM Compound: 8a, Xn	Inhibition of TrxR in human HeLa cells assessed as depletion of cellular thiol after 48 hrs Inhibition of TrxR in human HeLa cells assessed as depletion of cellular thiol after 48 hrs	[PMID: 25629304]
HeLa	IC₅₀	40.4 μM Compound: 8a, Xn	Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay	[PMID: 25629304]
HeLa	IC₅₀	9.4 μM Compound: 1	Cytotoxicity against human HeLa cells by MTT assay after 72 hrs Cytotoxicity against human HeLa cells by MTT assay after 72 hrs	[PMID: 18611049]
HeLa	IC₅₀	9.4 μM Compound: 1, xanthohumol	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 18343123]
HeLa	IC₅₀	9.4 μM Compound: 7	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 20153559]
HepG2	IC₅₀	35 μM Compound: 8a, Xn	Cytotoxicity against human HepG2 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay	[PMID: 25629304]
HMEC-1	IC₅₀	11.4 μM Compound: Xanthohumol	Antiangiogenic activity in SV-40T transfected human HMEC1 cells assessed as inhibition of cell proliferation after 72 hrs by crystal violet staining Antiangiogenic activity in SV-40T transfected human HMEC1 cells assessed as inhibition of cell proliferation after 72 hrs by crystal violet staining	[PMID: 23030826]
HMEC-1	IC₅₀	11.4 μM Compound: Xanthohumol	Antiproliferative activity against human HMEC1 cells after 72 hrs Antiproliferative activity against human HMEC1 cells after 72 hrs	[PMID: 25128665]
HT-29	IC₅₀	91.31 μM Compound: 1	Cytotoxicity against human HT-29 cells after 72 hrs by SRB assay Cytotoxicity against human HT-29 cells after 72 hrs by SRB assay	[PMID: 23434138]
HT-29	IC₅₀	91.31 μM Compound: 1, Xanthohumol	Antiproliferative activity against human HT-29 cells after 72 hrs by SRB assay Antiproliferative activity against human HT-29 cells after 72 hrs by SRB assay	[PMID: 23466227]
Ishikawa	IC₅₀	4.2 μM Compound: XH	Cytotoxicity against human Ishikawa cells after 96 hrs by SRB assay Cytotoxicity against human Ishikawa cells after 96 hrs by SRB assay	[PMID: 28812892]
MCF7	IC₅₀	10.95 μM Compound: 1	Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay	[PMID: 23434138]
MCF7	IC₅₀	10.95 μM Compound: 1, Xanthohumol	Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay	[PMID: 23466227]
MCF7	IC₅₀	13.3 μM Compound: Xanthohumol	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 2 days by SRB assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 2 days by SRB assay	[PMID: 33257172]
MCF7	IC₅₀	3.47 μM Compound: Xanthohumol	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 4 days by SRB assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 4 days by SRB assay	[PMID: 33257172]
NCI-H1975	IC₅₀	13 μM Compound: Xn	Antiproliferative activity against human NCI-H1975 cells after 72 hrs by MTT assay Antiproliferative activity against human NCI-H1975 cells after 72 hrs by MTT assay	[PMID: 30196062]
NCI-H460	IC₅₀	6.9 μM Compound: Xanthohumol	Cytotoxicity against human NCI-H460 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human NCI-H460 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 29288946]
NCI-H460	IC₅₀	7.5 μM Compound: Xn	Antiproliferative activity against human NCI-H460 cells after 72 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells after 72 hrs by MTT assay	[PMID: 30196062]
PC-3	IC₅₀	10.67 μM Compound: 1	Cytotoxicity against human PC3 cells after 72 hrs by SRB assay Cytotoxicity against human PC3 cells after 72 hrs by SRB assay	[PMID: 23434138]
PC-3	IC₅₀	10.67 μM Compound: 1, Xanthohumol	Antiproliferative activity against human PC3 cells after 72 hrs by SRB assay Antiproliferative activity against human PC3 cells after 72 hrs by SRB assay	[PMID: 23466227]
RAW264.7	IC₅₀	8.3 μM Compound: 1	Inhibition of LPS/IFN-gamma-induced NO production in mouse RAW264.7 cells after 16 hrs Inhibition of LPS/IFN-gamma-induced NO production in mouse RAW264.7 cells after 16 hrs	[PMID: 15679315]
SGC-7901	IC₅₀	10 μM Compound: Xanthohumol	Cytotoxicity against human SGC7901 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human SGC7901 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 29288946]
VSMC	IC₅₀	3.49 μM Compound: 1	Inhibition of PDGF-BB-induced rat VSMC proliferation preincubated for 30 mins followed by PDGF-BB addition measured after 48 hrs by resazurin assay Inhibition of PDGF-BB-induced rat VSMC proliferation preincubated for 30 mins followed by PDGF-BB addition measured after 48 hrs by resazurin assay	[PMID: 28627872]

Chemical Information

CAS No. 569-83-5
Molecular Weight 354.40
Formula C₂₁H₂₂O₅
SMILES

O=C(C1=C(OC)C=C(O)C(C/C=C(C)\C)=C1O)/C=C/C2=CC=C(O)C=C2
Structure Classification
- Flavonoids
- Other Flavonoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Rudolf Hänsel, et al. Desmethylxanthohumol: Isolierung aus Hopfen und Cyclisierung zu Flavanonen. Arch. Der Pharm.1988, 321, 1.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Get Quote In-stock