Art. -Nr.: HY-122778

δ-Tocotrienol

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

δ-Tocotrienol is a Vitamin E in vegetables, fruits, seeds, nuts, grains and oils. Vitamin E has become well known for its role as an antioxidant, in lowering cholesterol and other lipids, as a neuroprotective and anticancer agent, and in cardiovascular disease protection.

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Reinheit: 98.10%
CAS. Nr.: 25612-59-3
Formel: C₂₇H₄₀O₂
Molecular Weight:396.61

Speicherung:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

δ-Tocotrienol Chemical Structure

CAS. Nr.: 25612-59-3

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle NF-κB Isoform-spezifische Produkte anzeigen :

Alle AP-1 Isoform-spezifische Produkte anzeigen :

Alle Caspase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	19.7 μM Compound: 14	Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 48 hrs by Alamar blue assay Antiproliferative activity against human A2780 cells assessed as reduction in cell viability incubated for 48 hrs by Alamar blue assay	[PMID: 30354100]
Epithelial cell	IC₅₀	7 μM Compound: delta-tocotrienol	Antiproliferative activity against mouse +SA mammary epithelial cells after 4 days by MTT assay Antiproliferative activity against mouse +SA mammary epithelial cells after 4 days by MTT assay	[PMID: 18177013]
MCF7	IC₅₀	15.5 μM Compound: 3	Antiproliferative activity against human MCF7 cells after 96 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 96 hrs by MTT assay	[PMID: 20022507]
MDA-MB-231	IC₅₀	>10 μM Compound: 3	Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by MTT assay	[PMID: 20022507]
MDA-MB-231	IC₅₀	>40 μM Compound: 2	Antimigratory activity against human MDA-MB-231 cells after 24 hrs by wound-healing assay Antimigratory activity against human MDA-MB-231 cells after 24 hrs by wound-healing assay	[PMID: 23274571]
Neutrophil	IC₅₀	14.8 μM Compound: 9	Antiinflammatory activity in human neutrophils assessed as inhibition of fMet-Leu-Phe/Cytochalasin B-induced superoxide anion generation treated 5 mins before fMet-Leu-Phe/Cytochalasin B challenge by spectrophotometry Antiinflammatory activity in human neutrophils assessed as inhibition of fMet-Leu-Phe/Cytochalasin B-induced superoxide anion generation treated 5 mins before fMet-Leu-Phe/Cytochalasin B challenge by spectrophotometry	[PMID: 19203247]
Neutrophil	IC₅₀	15.12 μM Compound: 9	Antiinflammatory activity in human neutrophils assessed as inhibition of fMet-Leu-Phe/Cytochalasin B-induced elastase release treated 5 mins before fMet-Leu-Phe/Cytochalasin B challenge Antiinflammatory activity in human neutrophils assessed as inhibition of fMet-Leu-Phe/Cytochalasin B-induced elastase release treated 5 mins before fMet-Leu-Phe/Cytochalasin B challenge	[PMID: 19203247]

In Vitro

δ-Tocotrienol (10-80 µM, 72 h) inhibits the proliferation of cancer cell CNE1, CNE2, EC109, HONE1, HCT116, and MCF-7^[1].
δ-Tocotrienol (0-40 µM, 24 h) inhibits AP-1 and NF-κB signaling pathway, activates caspase-3/8/9, arrests the cell cycle at G0/G1 phases, induces apoptosis in human nasopharyngeal carcinoma cell CNE1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

CNE1
Concentration:

0-40 µM
Incubation Time:

24 h
Result:

Upregulated the expression of p16, p21 and p53, downregulated the expression of Cyclin D1.
Upregulated levels of cleaved caspase-3/8/9.

In Vivo

δ-Tocotrienol (75 mg/kg, sc, single dose) exhibits anti-inflammatory effect against radiation-induced gastrointestinal injury in CD2F1 mouse models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mouse gastrointestinal injury models^[2]
Dosage:

75 mg/kg
Administration:

sc, single dose
Result:

Inhibited IL-1β and IL-6 production.
Protected the intestinal tissues, inhibited intestinal bacterial translocation.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 25612-59-3
Appearance Liquid (Density: 0.968±0.06 g/cm³)
Molecular Weight 396.61
Formel C₂₇H₄₀O₂
Color Colorless to light yellow
SMILES

C/C(CC/C=C(CC/C=C(C)\C)\C)=C\CC[C@]1(OC2=C(C=C(C=C2CC1)O)C)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Bioengineered

δ-tocotrienol suppresses the migration and angiogenesis of trophoblasts in preeclampsia and promotes their apoptosis via miR-429/ ZEB1 axis. [Abstract]

2021 Dec;12(1):1861-1873 PMID: 34002673

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (252.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5214 mL

12.6068 mL

25.2137 mL

5 mM

0.5043 mL

2.5214 mL

5.0427 mL

10 mM

0.2521 mL

1.2607 mL

2.5214 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2.5 mg/mL (6.30 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (6.30 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (6.30 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Shen J, et al., δ-Tocotrienol induces apoptosis and inhibits proliferation of nasopharyngeal carcinoma cells. Food Funct. 2021 Jul 21;12(14):6374-6388. [Content Brief]

[2]. Li XH, et al., Delta-tocotrienol protects mice from radiation-induced gastrointestinal injury. Radiat Res. 2013 Dec;180(6):649-57. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5214 mL	12.6068 mL	25.2137 mL	63.0342 mL
	5 mM	0.5043 mL	2.5214 mL	5.0427 mL	12.6068 mL
	10 mM	0.2521 mL	1.2607 mL	2.5214 mL	6.3034 mL
	15 mM	0.1681 mL	0.8405 mL	1.6809 mL	4.2023 mL
	20 mM	0.1261 mL	0.6303 mL	1.2607 mL	3.1517 mL
	25 mM	0.1009 mL	0.5043 mL	1.0085 mL	2.5214 mL
	30 mM	0.0840 mL	0.4202 mL	0.8405 mL	2.1011 mL
	40 mM	0.0630 mL	0.3152 mL	0.6303 mL	1.5759 mL
	50 mM	0.0504 mL	0.2521 mL	0.5043 mL	1.2607 mL
	60 mM	0.0420 mL	0.2101 mL	0.4202 mL	1.0506 mL
	80 mM	0.0315 mL	0.1576 mL	0.3152 mL	0.7879 mL
	100 mM	0.0252 mL	0.1261 mL	0.2521 mL	0.6303 mL

Keywords

δ-Tocotrienol

1 Cited Publications

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δ-Tocotrienol

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Publications Citing Use of MedChemExpress (MCE) δ-Tocotrienol

Alle NF-κB Isoform-spezifische Produkte anzeigen

Alle AP-1 Isoform-spezifische Produkte anzeigen

Alle Caspase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

δ-Tocotrienol Related Classifications

HY-122778 Related Classifications