Z-Doxepin-d3 Hydrochloride
Z-Doxepin-d3 hydrochloride is the deuterium labeled 7-Hydroxychlorpromazine hydrochloride (HY-W704749). 7-Hydroxychlorpromazine hydrochloride is the active metabolite of Chlorpromazine (HY-12708). 7-Hydroxychlorpromazine hydrochloride can increase prolactin levels in rats. 7-Hydroxychlorpromazine hydrochloride can increase dopamine turnover and has a sedative effect. In addition, 7-Hydroxychlorpromazine hydrochloride can effectively inhibit amphetamine-induced stereotyped behavior in rats and is used in the study of psychosis.
For research use only. We do not sell to patients.
- CAS No.: 2469242-68-8
- Formula: C17H14D6Cl2N2OS
- Molecular Weight:377.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2469242-68-8
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Unlabeled Cas 51938-11-5
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Molecular Weight 377.36
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Formula C17H14D6Cl2N2OS
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SMILES
ClC(C=C1)=CC2=C1SC(C=C(O)C=C3)=C3N2CCCN(C([2H])([2H])[2H])C([2H])([2H])[2H].Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Meltzer H Y, et al. Effect of metabolites of chlorpromazine on plasma prolactin levels in male rats[J]. European Journal of Pharmacology, 1977, 41(4): 431-436. [Content Brief]
[2]. Perry T L, et al. 7-Hydroxychlorpromazine: potential toxic drug metabolite in psychiatric patients[J]. Science, 1964, 146(3640): 81-83. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Z-Doxepin-d3 Hydrochloride Related Classifications
HY-W704752 Related Classifications
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