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Thioredoxin Reductase 2 Antibody (YA661)

(Synonyms: mitochondrial; selenoprotein Z; SELZ; Thioredoxin reductase 2; Thioredoxin reductase 2 mitochondrial; thioredoxin reductase 3; thioredoxin reductase beta; Thioredoxin reductase TR3; TR 3; TR; TR beta; TR-beta; TRXR 2; TRXR2; TRXR2_HUMAN; TXNRD 2; Txnrd2.)

Thioredoxin Reductase 2 Antibody (YA661) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Thioredoxin Reductase 2.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG

  • Application:

    WB

  • Reactivity :

    Human

  • Formulation:

    Supplied in 1*PBS (pH 7.3), 50% glycerol and 0.5% BSA. Preservative: 0.02% sodium azide.

  • Conjugation:
    Non-conjugated
  • Thioredoxin Reductase 2 Antibody (YA661) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
Dilution Ratio 1:500-1:1000

Product Details

Description

Thioredoxin Reductase 2 Antibody (YA661) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Thioredoxin Reductase 2.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 57 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 57 kDa
Species Reactivity Database

Entrez Gene: 10587 Human

SwissProt: Q9NNW7 Human

Immunogen

Synthetic peptide corresponding to Human TXNRD2.The exact sequence is proprietary to MCE.

Sensitivity

Endogenous

Purification

affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in 1*PBS (pH 7.3), 50% glycerol and 0.5% BSA. Preservative: 0.02% sodium azide.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    Thioredoxin Reductase 2 is involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis. Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling[1].

  • Subcellular Localization

    Mitochondrion

  • Expression


    Tissue_specificity:It is highly expressed in the prostate, ovary, liver, testis, uterus, colon, and small intestine. Moderate expression is observed in the brain, skeletal muscle, heart, and spleen. Low expression is found in the placenta, pancreas, thymus, and peripheral blood leukocytes. High expression is observed in the kidneys according to PubMed:10608886, while low expression is observed in the kidneys according to PubMed:9923614. High expression has also been observed in the adrenal cortex (PubMed:24601690) .

  • Isoforms & Post-Translational Modification

    Q9NNW7 has 4 isomers: Q9NNW7-1: 56507 Da (predicted); Q9NNW7-2: 53970 Da (predicted); Q9NNW7-3: 46841 Da (predicted); Q9NNW7-4: 30291 Da (predicted).

  • Subunit

    Homodimer

  • SwissProt ID

    Q9NNW7

  • Gene ID
    10587 [NCBI]
  • Synonyms

    mitochondrial; selenoprotein Z; SELZ; Thioredoxin reductase 2; Thioredoxin reductase 2 mitochondrial; thioredoxin reductase 3; thioredoxin reductase beta; Thioredoxin reductase TR3; TR 3; TR; TR beta; TR-beta; TRXR 2; TRXR2; TRXR2_HUMAN; TXNRD 2; Txnrd2.

  • Research Field

    Cell Biology

[1]. Prasad R, et al. Thioredoxin Reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD). J Clin Endocrinol Metab. 2014 Aug;99(8):E1556-63. [Content Brief]

Thioredoxin Reductase 2 Antibody (YA661) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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