2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies
  5. Thioredoxin Reductase 2 Antibody (YA661)

Thioredoxin Reductase 2 Antibody (YA661)

Cat. No.: HY-P80913
User Guide for Antibodies Technical Support

Thioredoxin Reductase 2 Antibody (YA661) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Thioredoxin Reductase 2.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

Thioredoxin Reductase 2 Antibody (YA661) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Thioredoxin Reductase 2.
Host

Mouse
Clonality

Monoclonal
Molecular Weight
Predicted band size: 57 kDa;
Observed band size: 57 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

Synthetic peptide corresponding to Human TXNRD2.The exact sequence is proprietary to MCE.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
Sensitivity Endogenous Purity affinity purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG1  
Appearance

Liquid
Formulation

Supplied in 1*PBS (pH 7.3), 50% glycerol and 0.5% BSA. Preservative: 0.02% sodium azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (PubMed:24601690). Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling
Subcellular Localization：Mitochondrion
Expression：
Tissue_specificity:It is highly expressed in the prostate, ovary, liver, testis, uterus, colon, and small intestine. Moderate expression is observed in the brain, skeletal muscle, heart, and spleen. Low expression is found in the placenta, pancreas, thymus, and peripheral blood leukocytes. High expression is observed in the kidneys according to PubMed:10608886, while low expression is observed in the kidneys according to PubMed:9923614. High expression has also been observed in the adrenal cortex (PubMed:24601690) .
Isoforms & Post-Translational Modification：Q9NNW7 has 4 isomers: Q9NNW7-1: 56507 Da (predicted); Q9NNW7-2: 53970 Da (predicted); Q9NNW7-3: 46841 Da (predicted); Q9NNW7-4: 30291 Da (predicted).
Subunit：Homodimer
Database

Entrez Gene: 10587 Human

SwissProt: Q9NNW7 Human

OMIM: 617825 Human

Research Field

Cell Biology
Synonyms
mitochondrial; selenoprotein Z; SELZ; Thioredoxin reductase 2; Thioredoxin reductase 2 mitochondrial; thioredoxin reductase 3; thioredoxin reductase beta; Thioredoxin reductase TR3; TR 3; TR; TR beta; TR-beta; TRXR 2; TRXR2; TRXR2_HUMAN; TXNRD 2; Txnrd2.
Documentation
User Guide for Antibodies (1077 KB)

Thioredoxin Reductase 2 Antibody (YA661) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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