(E/Z)-Elafibranor (Synonyms: (E/Z)-GFT505)

Cat. No.: HY-16737A Purity: 98.36%: Data Sheet
COA

SDS
Handling Instructions
FAQs
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(E/Z)-Elafibranor ((E/Z)-GFT505) is a PPARα/δ agonist with EC₅₀s of 45 and 175 nM, respectively.

For research use only. We do not sell to patients.

(E/Z)-Elafibranor Chemical Structure

CAS No. : 824932-88-9

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Other Forms of (E/Z)-Elafibranor:

Elafibranor In-stock

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PPARα PPARβ/δ PPARγ PPAR PPARδ

Biological Activity
Purity & Documentation
References
Customer Review

Description

(E/Z)-Elafibranor ((E/Z)-GFT505) is a PPARα/δ agonist with EC₅₀s of 45 and 175 nM, respectively^[1]^[2]^[3].

IC₅₀ & Target

EC50: 45 nM (PPAR-α), 175 nM (PPAR-δ)^[1]

Molecular Weight

384.49

Formula

C₂₂H₂₄O₄S

CAS No.

824932-88-9

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C(C)(C)OC1=C(C)C=C(/C=C/C(C2=CC=C(C=C2)SC)=O)C=C1C)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 60 mg/mL (156.05 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6008 mL	13.0042 mL	26.0085 mL
5 mM	0.5202 mL	2.6008 mL	5.2017 mL
10 mM	0.2601 mL	1.3004 mL	2.6008 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.36%

Select Batch:

Data Sheet (270 KB) SDS (254 KB)

COA (244 KB) HNMR (284 KB) LCMS (162 KB)

Handling Instructions (2659 KB)

References

[1]. Liu ZM, et al. Early investigational drugs targeting PPAR-α for the treatment of metabolic disease.Expert Opin Investig Drugs. 2015 May;24(5):611-21. [Content Brief]

[2]. Ratziu V, et al. Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening. Gastroenterology. 2016 May;150(5):1147-1159. [Content Brief]

[3]. Hanf R, et al. The dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 exerts anti-diabetic effects in db/db mice without peroxisome proliferator-activated receptor gamma-associated adverse cardiac effects.Diab Vasc Dis Res. 2014 No [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6008 mL	13.0042 mL	26.0085 mL	65.0212 mL
	5 mM	0.5202 mL	2.6008 mL	5.2017 mL	13.0042 mL
	10 mM	0.2601 mL	1.3004 mL	2.6008 mL	6.5021 mL
	15 mM	0.1734 mL	0.8669 mL	1.7339 mL	4.3347 mL
	20 mM	0.1300 mL	0.6502 mL	1.3004 mL	3.2511 mL
	25 mM	0.1040 mL	0.5202 mL	1.0403 mL	2.6008 mL
	30 mM	0.0867 mL	0.4335 mL	0.8669 mL	2.1674 mL
	40 mM	0.0650 mL	0.3251 mL	0.6502 mL	1.6255 mL
	50 mM	0.0520 mL	0.2601 mL	0.5202 mL	1.3004 mL
	60 mM	0.0433 mL	0.2167 mL	0.4335 mL	1.0837 mL
	80 mM	0.0325 mL	0.1626 mL	0.3251 mL	0.8128 mL
	100 mM	0.0260 mL	0.1300 mL	0.2601 mL	0.6502 mL

(E/Z)-Elafibranor Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E/Z)-Elafibranor824932-88-9(E/Z)-GFT505PPARPeroxisome proliferator-activated receptorsInhibitorinhibitorinhibit

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