824932-88-9
824932-88-9
Chemical Structure
(E/Z)-Elafibranor
Synonym(s): (E/Z)-GFT505
- CAS No.: 824932-88-9
- Formula:C22H24O4S
- Molecular Weight:384.49
IUPAC Name: (E)-2-(2,6-dimethyl-4-(3-(4-(methylthio)phenyl)-3-oxoprop-1-en-1-yl)phenoxy)-2-methylpropanoic acid
InChIKey: AFLFKFHDSCQHOL-IZZDOVSWSA-N
SMILES: O=C(C(C)(C)OC1=C(C)C=C(/C=C/C(C2=CC=C(C=C2)SC)=O)C=C1C)O
Biological Activity: (E/Z)-Elafibranor ((E/Z)-GFT505) is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively[1][2][3].
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(E/Z)-Elafibranor | 98.36% | (E/Z)-Elafibranor ((E/Z)-GFT505) is a PPARα/δ agonist with EC50s of 45 and 175 nM, respectively. | ||||||||||||||||||||
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References
- [1]. Liu ZM, et al. Early investigational drugs targeting PPAR-α for the treatment of metabolic disease.Expert Opin Investig Drugs. 2015 May;24(5):611-21. [Content Brief]
- [2]. Ratziu V, et al. Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening. Gastroenterology. 2016 May;150(5):1147-1159. [Content Brief]
- [3]. Hanf R, et al. The dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 exerts anti-diabetic effects in db/db mice without peroxisome proliferator-activated receptor gamma-associated adverse cardiac effects.Diab Vasc Dis Res. 2014 No [Content Brief]
Keywords
