Thioredoxin Reductase 2 Antibody (YA5251)

Cat. No.: HY-P85559: Data Sheet User Guide for Antibodies
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Thioredoxin Reductase 2 Antibody (YA5251) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Thioredoxin Reductase 2.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Thioredoxin Reductase 2 Antibody (YA5251) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Thioredoxin Reductase 2.

Host

Rabbit

Clonality

Monoclonal

Molecular Weight

Observed band size: 56 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q9NNW7

Gene ID

10587 [NCBI]

Immunogen

Purified full length recombinant human TXNRD2 protein expressed in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1000
IF-Tissue IF-Tissue: Immunofluorescence-Tissue	1:50-100

Sensitivity	Endogenous	Purity	affinity chromatography.
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (PubMed:24601690). Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling

Subcellular Localization：Mitochondrion

Expression：
Tissue_specificity:It is highly expressed in the prostate, ovary, liver, testis, uterus, colon, and small intestine. Moderate expression is observed in the brain, skeletal muscle, heart, and spleen. Low expression is found in the placenta, pancreas, thymus, and peripheral blood leukocytes. High expression is observed in the kidneys according to PubMed:10608886, while low expression is observed in the kidneys according to PubMed:9923614. High expression has also been observed in the adrenal cortex (PubMed:24601690) .

Isoforms & Post-Translational Modification：Q9NNW7 has 4 isomers: Q9NNW7-1: 56507 Da (predicted); Q9NNW7-2: 53970 Da (predicted); Q9NNW7-3: 46841 Da (predicted); Q9NNW7-4: 30291 Da (predicted).

Subunit：Homodimer

Synonyms

mitochondrial; selenoprotein Z; SELZ; Thioredoxin reductase 2; Thioredoxin reductase 2 mitochondrial; thioredoxin reductase 3; thioredoxin reductase beta; Thioredoxin reductase TR3; TR 3; TR; TR beta; TR-beta; TRXR 2; TRXR2; TRXR2_HUMAN; TXNRD 2; Txnrd2.

Documentation

User Guide for Antibodies (1077 KB)