(E/Z)-BIX02189
(E/Z)-BIX02189 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 1094614-85-3
- Formule: C27H28N4O2
- Masse moléculaire:440.54
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
59 nM
Compound: BIX02189
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Inhibition of ERK5 phosphorylation in sorbitol-stimulated human HeLa cells
Inhibition of ERK5 phosphorylation in sorbitol-stimulated human HeLa cells
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[PMID: 23656407] |
BIX 02189 is a selective MEK5 inhibitor with IC50 of 1.5 nM, also inhibits the catalytic activity of ERK5 with IC50 of 810 nM, without inhibiting its closely related kinases MEK1, MEK2, ERK2, and JNK2.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1094614-85-3
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Masse moléculaire 440.54
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Formule C27H28N4O2
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SMILES
O=C(N(C)C)C1=CC(NC2=O)=C(/C2=C(C3=CC=CC=C3)/NC4=CC=CC(CN(C)C)=C4)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (244 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)