(E/Z)-BIX02189
(E/Z)-BIX02189 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
For research use only. We do not sell to patients.
- CAS No.: 1094614-85-3
- Formula: C27H28N4O2
- Molecular Weight:440.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
59 nM
Compound: BIX02189
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Inhibition of ERK5 phosphorylation in sorbitol-stimulated human HeLa cells
Inhibition of ERK5 phosphorylation in sorbitol-stimulated human HeLa cells
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[PMID: 23656407] |
BIX 02189 is a selective MEK5 inhibitor with IC50 of 1.5 nM, also inhibits the catalytic activity of ERK5 with IC50 of 810 nM, without inhibiting its closely related kinases MEK1, MEK2, ERK2, and JNK2.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1094614-85-3
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Molecular Weight 440.54
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Formula C27H28N4O2
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SMILES
O=C(N(C)C)C1=CC(NC2=O)=C(/C2=C(C3=CC=CC=C3)/NC4=CC=CC(CN(C)C)=C4)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (244 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)