2. Metabolic Enzyme/Protease Neuronal Signaling NF-κB
  3. Glycosidase Amyloid-β NF-κB
  4. CHI3L1-IN-5

CHI3L1-IN-5 (Compound Z17) is a highly selective CHI3L1 inhibitor with a KD value of 6 μM. CHI3L1-IN-5 restores the clearance ability of astrocytes by rejuvenating lysosomal function and Aβ uptake. CHI3L1-IN-5 alleviates neuroinflammation by inhibiting the NF-κB pathway. CHI3L1-IN-5 can be used for research on Alzheimer's disease.

For research use only. We do not sell to patients.

CHI3L1-IN-5

CHI3L1-IN-5 Chemical Structure

CAS No. : 2249043-42-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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10 mg In-stock
25 mg In-stock
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Based on 1 publication(s) in Google Scholar

CHI3L1-IN-5 Related Antibodies

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View All NF-κB Isoform Specific Products:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Description

CHI3L1-IN-5 (Compound Z17) is a highly selective CHI3L1 inhibitor with a KD value of 6 μM. CHI3L1-IN-5 restores the clearance ability of astrocytes by rejuvenating lysosomal function and Aβ uptake. CHI3L1-IN-5 alleviates neuroinflammation by inhibiting the NF-κB pathway. CHI3L1-IN-5 can be used for research on Alzheimer's disease[1].

Molecular Weight

343.40

Formula

C19H22FN3O2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(C1=CC(C=CC=C2F)=C2N=C1)N3CCCCC3CC(NCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (291.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9121 mL 14.5603 mL 29.1206 mL
5 mM 0.5824 mL 2.9121 mL 5.8241 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9121 mL 14.5603 mL 29.1206 mL 72.8014 mL
5 mM 0.5824 mL 2.9121 mL 5.8241 mL 14.5603 mL
10 mM 0.2912 mL 1.4560 mL 2.9121 mL 7.2801 mL
15 mM 0.1941 mL 0.9707 mL 1.9414 mL 4.8534 mL
20 mM 0.1456 mL 0.7280 mL 1.4560 mL 3.6401 mL
25 mM 0.1165 mL 0.5824 mL 1.1648 mL 2.9121 mL
30 mM 0.0971 mL 0.4853 mL 0.9707 mL 2.4267 mL
40 mM 0.0728 mL 0.3640 mL 0.7280 mL 1.8200 mL
50 mM 0.0582 mL 0.2912 mL 0.5824 mL 1.4560 mL
60 mM 0.0485 mL 0.2427 mL 0.4853 mL 1.2134 mL
80 mM 0.0364 mL 0.1820 mL 0.3640 mL 0.9100 mL
100 mM 0.0291 mL 0.1456 mL 0.2912 mL 0.7280 mL
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CHI3L1-IN-5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHI3L1-IN-52249043-42-1GlycosidaseAmyloid-βNF-κBβ-amyloid peptideAβAbetaNuclear factor-κBNuclear factor-kappaBCHI3L1 inhibitorAlzheimer's diseaseneuroinflammationastrocytesamyloid-β clearancelysosomal functionNF-κB signalingpharmacokineticsstructure-activity relationshipInhibitorinhibitorinhibit

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