2249043-42-1
2249043-42-1
Chemical Structure
CHI3L1-IN-5
- CAS No.: 2249043-42-1
- Formula:C19H22FN3O2
- Molecular Weight:343.40
InChIKey: URJNAXWJDONBKW-UHFFFAOYSA-N
SMILES: O=C(C1=CC(C=CC=C2F)=C2N=C1)N3CCCCC3CC(NCC)=O
Biological Activity: CHI3L1-IN-5 (Compound Z17) is a highly selective CHI3L1 inhibitor with a KD value of 6 μM. CHI3L1-IN-5 restores the clearance ability of astrocytes by rejuvenating lysosomal function and Aβ uptake. CHI3L1-IN-5 alleviates neuroinflammation by inhibiting the NF-κB pathway. CHI3L1-IN-5 can be used for research on Alzheimer's disease[1].
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CHI3L1-IN-5 | 98.60% | CHI3L1-IN-5 (Compound Z17) is a highly selective CHI3L1 inhibitor with a KD value of 6 μM. CHI3L1-IN-5 restores the clearance ability of astrocytes by rejuvenating lysosomal function and Aβ uptake. CHI3L1-IN-5 alleviates neuroinflammation by inhibiting the NF-κB pathway. CHI3L1-IN-5 can be used for research on Alzheimer's disease. | ||||||||||||||||||||
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