2. Metabolic Enzyme/Protease
  3. FXR
  4. ZLY28

ZLY28 is the first-in-class intestinal restricted and orally active FXR and FABP1 dual modulator. ZLY28 also is a novel anti-NASH agent. ZLY28 can be used for the research of nonalcoholic steatohepatitis (NASH).

For research use only. We do not sell to patients.

ZLY28 Chemical Structure

ZLY28 Chemical Structure

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ZLY28 Related Antibodies

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Description

ZLY28 is the first-in-class intestinal restricted and orally active FXR and FABP1 dual modulator. ZLY28 also is a novel anti-NASH agent. ZLY28 can be used for the research of nonalcoholic steatohepatitis (NASH)[1].
IC50 & Target

EC50: 143 nM (FXR)[1].
IC50: 2.7 μM (FABP1)[1].
In Vitro

ZLY28 has suitable stability of liver microsomes and high target selectivity for FXR (EC50 = 143 nM) and FABP1 (IC50 = 2.7 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ZLY28 Related Antibodies
In Vivo

ZLY28 (oral; 20 mg/kg) significantly alleviates fatty liver by regulating multiple pathogeneses, including lipid metabolism, inflammation, oxidative stress, and fibrosis in the NASH mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8 weeks old male C57BL/6 mice[1]
Dosage: 20 mg/kg
Administration: Oral administration
Result: Mainly distributed in the ileum with an ileum/plasma ratio of 104.1.
Significantly alleviated hepatic steatosis, lobular inflammation and ballooning.
Improved hepatic lipid homeostasis by inhibiting lipogenesis and promoting lipolysis.
Downregulated the gene expression levels.
Exhibited an acceptable safety profile with no acute toxicity.
Molecular Weight

520.40

Formula

C29H23Cl2NO4
SMILES

O=C(C1(C2=CC(C3=CC=C(OCC4=C(C5CC5)ON=C4C6=C(Cl)C=CC=C6Cl)C=C3)=CC=C2)CC1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ZLY28 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZLY28ZLY 28ZLY-28FXRNR1H4first-in-classFABP1anti-NASHnonalcoholic steatohepatitis (NASH)Inhibitorinhibitorinhibit

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