1. Metabolic Enzyme/Protease
  2. Drug Metabolite
  3. (Z)2S,4R-Sacubitril

(Z)2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.

For research use only. We do not sell to patients.

(Z)2S,4R-Sacubitril Chemical Structure

(Z)2S,4R-Sacubitril Chemical Structure

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10 mg USD 96 In-stock
50 mg USD 180 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (Z)2S,4R-Sacubitril:

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Description

(Z)2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.

Molecular Weight

409.47

Formula

C24H27NO5

Appearance

Solid

Color

White to off-white

SMILES

[H]N(C(/C=C\C(O)=O)=O)[C@H](CC(C=C1)=CC=C1C2=CC=CC=C2)C[C@@H](C)C(OCC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (244.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4422 mL 12.2109 mL 24.4218 mL
5 mM 0.4884 mL 2.4422 mL 4.8844 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4422 mL 12.2109 mL 24.4218 mL 61.0545 mL
5 mM 0.4884 mL 2.4422 mL 4.8844 mL 12.2109 mL
10 mM 0.2442 mL 1.2211 mL 2.4422 mL 6.1055 mL
15 mM 0.1628 mL 0.8141 mL 1.6281 mL 4.0703 mL
20 mM 0.1221 mL 0.6105 mL 1.2211 mL 3.0527 mL
25 mM 0.0977 mL 0.4884 mL 0.9769 mL 2.4422 mL
30 mM 0.0814 mL 0.4070 mL 0.8141 mL 2.0352 mL
40 mM 0.0611 mL 0.3053 mL 0.6105 mL 1.5264 mL
50 mM 0.0488 mL 0.2442 mL 0.4884 mL 1.2211 mL
60 mM 0.0407 mL 0.2035 mL 0.4070 mL 1.0176 mL
80 mM 0.0305 mL 0.1526 mL 0.3053 mL 0.7632 mL
100 mM 0.0244 mL 0.1221 mL 0.2442 mL 0.6105 mL
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(Z)2S,4R-Sacubitril Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
(Z)2S,4R-Sacubitril
Cat. No.:
HY-Z0075
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