D-Lys(Z)-Pro-Arg-pNA diacetate
Based on 1 publication(s) in Google Scholar
D-Lys(Z)-Pro-Arg-pNA diacetate is a chromogenic peptide substrate of activated protein C (APC).
For research use only. We do not sell to patients.
- Purity: 99.07%
- CAS No.: 108963-70-8
- Formula: C35H51N9O11
- Molecular Weight:773.83
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Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) D-Lys(Z)-Pro-Arg-pNA diacetate
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Biological Activity
Guide (The following is our recommended protocol. This protocol is only a guide and should be modified according to your specific needs).
Cleavage of Chromogenic Substrates.[1]
APC derivatives (2 nM) and D-Lys(Z)-Pro-Arg-pNA (15-2000 μM) are mixed in 0.1 M NaCl, 0.02 M Tris-HCl (TBS, pH 7.5) containing 2.5 mM Ca2+, 0.1 mg/mL BSA, and 0.1% PEG 8000.
The rate of hydrolysis was measured at 405 nm at room temperature in a Vmax kinetic microplate reader.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Chemical Information
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CAS No. 108963-70-8
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Appearance Solid
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Molecular Weight 773.83
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Formula C35H51N9O11
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Color White to light yellow
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SMILES
CC(O)=O.CC(O)=O.O=C(NCCCC[C@@H](N)C(N1CCC[C@H]1C(N[C@H](C(NC2=CC=C([N+]([O-])=O)C=C2)=O)CCCNC(N)=N)=O)=O)OCC3=CC=CC=C3
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Synonyms
Spectrozyme PCa; Chromozym Pca diacetate
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Sequence Shortening
{d-Lys(Z)}-P-R-pNA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 25 mg/mL (32.31 mM; ultrasonic and adjust pH to 4 with CH3COOH; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 2 mg/mL (2.58 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.2923 mL | 6.4614 mL | 12.9227 mL | 32.3068 mL |
| DMSO | 5 mM | 0.2585 mL | 1.2923 mL | 2.5845 mL | 6.4614 mL |
| 10 mM | 0.1292 mL | 0.6461 mL | 1.2923 mL | 3.2307 mL | |
| 15 mM | 0.0862 mL | 0.4308 mL | 0.8615 mL | 2.1538 mL | |
| 20 mM | 0.0646 mL | 0.3231 mL | 0.6461 mL | 1.6153 mL | |
| 25 mM | 0.0517 mL | 0.2585 mL | 0.5169 mL | 1.2923 mL | |
| 30 mM | 0.0431 mL | 0.2154 mL | 0.4308 mL | 1.0769 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
D-Lys(Z)-Pro-Arg-pNA diacetate Related Classifications
HY-P0021A Related Classifications
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