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製品番号: HY-162013

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NLRP3-IN-26

NLRP3-IN-26 (compound 15Z) is a NLRP3 inhibitor with the IC₅₀ of 0.13 μM. NLRP3-IN-26 can be used for DSS-induced colitis model study.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2927413-30-5
分子式: C₃₁H₃₃ClN₂O₆S
分子量:597.12

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

NLRP3-IN-26 構造式

CAS 番号: 2927413-30-5

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

NLRP3-IN-26 (compound 15Z) is a NLRP3 inhibitor with the IC₅₀ of 0.13 μM. NLRP3-IN-26 can be used for DSS-induced colitis model study^[1].

NOD-like Receptor (NLR) アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
J774.A1	CC₅₀	>30 μM Compound: 15z, Diastereomeric mixture	Cytotoxicity against mouse J774.A1 cells incubated for 24 hrs by resazurin reagent based assay Cytotoxicity against mouse J774.A1 cells incubated for 24 hrs by resazurin reagent based assay	[PMID: 38029358]
L02	CC₅₀	>1000 μM Compound: 15z, Diastereomeric mixture	Cytotoxicity against human HL7702 cells incubated for 48 hrs by resazurin reagent based assay Cytotoxicity against human HL7702 cells incubated for 48 hrs by resazurin reagent based assay	[PMID: 38029358]

化学情報

CAS 番号 2927413-30-5
分子量 597.12
分子式 C₃₁H₃₃ClN₂O₆S
SMILES

O=C(N(C1CC2=CC=C(S(=O)(NCCC)=O)C=C2C1)CC3=CC(Cl)=CC=C3OCCOC)C4=CC5=C(C=CC=C5)O4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Sun S, et al. Discovery of Novel 2,3-Dihydro-1H-indene-5-sulfonamide NLRP3 Inflammasome Inhibitors Targeting Colon as a Potential Therapy for Colitis. J Med Chem. 2023;66(23):16141-16167. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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