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Cat. No.: HY-162013

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NLRP3-IN-26

NLRP3-IN-26 (compound 15Z) is a NLRP3 inhibitor with the IC₅₀ of 0.13 μM. NLRP3-IN-26 can be used for DSS-induced colitis model study.

For research use only. We do not sell to patients.

CAS No.: 2927413-30-5
Formula: C₃₁H₃₃ClN₂O₆S
Molecular Weight:597.12

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

NLRP3-IN-26 Chemical Structure

CAS No.: 2927413-30-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

NLRP3-IN-26 (compound 15Z) is a NLRP3 inhibitor with the IC₅₀ of 0.13 μM. NLRP3-IN-26 can be used for DSS-induced colitis model study^[1].

All NOD-like Receptor (NLR) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
J774.A1	CC₅₀	>30 μM Compound: 15z, Diastereomeric mixture	Cytotoxicity against mouse J774.A1 cells incubated for 24 hrs by resazurin reagent based assay Cytotoxicity against mouse J774.A1 cells incubated for 24 hrs by resazurin reagent based assay	[PMID: 38029358]
L02	CC₅₀	>1000 μM Compound: 15z, Diastereomeric mixture	Cytotoxicity against human HL7702 cells incubated for 48 hrs by resazurin reagent based assay Cytotoxicity against human HL7702 cells incubated for 48 hrs by resazurin reagent based assay	[PMID: 38029358]

Chemical Information

CAS No. 2927413-30-5
Molecular Weight 597.12
Formula C₃₁H₃₃ClN₂O₆S
SMILES

O=C(N(C1CC2=CC=C(S(=O)(NCCC)=O)C=C2C1)CC3=CC(Cl)=CC=C3OCCOC)C4=CC5=C(C=CC=C5)O4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sun S, et al. Discovery of Novel 2,3-Dihydro-1H-indene-5-sulfonamide NLRP3 Inflammasome Inhibitors Targeting Colon as a Potential Therapy for Colitis. J Med Chem. 2023;66(23):16141-16167. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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