2. Protein Tyrosine Kinase/RTK
  3. c-Met/HGFR
  4. (Z)-Semaxanib

(Z)-Semaxanib (compound (z)-1) is a potent tyrosine kinase inhibitor. (Z)-Semaxanib shows cytotoxicity for TAMH and HepG2 cells with IC50s of 6.28 µM and 8.17 µM, respectively.

For research use only. We do not sell to patients.

(Z)-Semaxanib

(Z)-Semaxanib Chemical Structure

CAS No. : 194413-58-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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50 mg In-stock
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1 g In-stock
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Based on 3 publication(s) in Google Scholar

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(Z)-Semaxanib Related Antibodies

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Description

(Z)-Semaxanib (compound (z)-1) is a potent tyrosine kinase inhibitor. (Z)-Semaxanib shows cytotoxicity for TAMH and HepG2 cells with IC50s of 6.28 µM and 8.17 µM, respectively[1].

Molecular Weight

238.29

Formula

C15H14N2O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1=C/2C=CC=C1)C2=C/C3=C(C)C=C(C)N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (209.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1966 mL 20.9828 mL 41.9657 mL
5 mM 0.8393 mL 4.1966 mL 8.3931 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.72%

SDS (393 KB)

COA (254 KB) HNMR (254 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.1966 mL 20.9828 mL 41.9657 mL 104.9142 mL
5 mM 0.8393 mL 4.1966 mL 8.3931 mL 20.9828 mL
10 mM 0.4197 mL 2.0983 mL 4.1966 mL 10.4914 mL
15 mM 0.2798 mL 1.3989 mL 2.7977 mL 6.9943 mL
20 mM 0.2098 mL 1.0491 mL 2.0983 mL 5.2457 mL
25 mM 0.1679 mL 0.8393 mL 1.6786 mL 4.1966 mL
30 mM 0.1399 mL 0.6994 mL 1.3989 mL 3.4971 mL
40 mM 0.1049 mL 0.5246 mL 1.0491 mL 2.6229 mL
50 mM 0.0839 mL 0.4197 mL 0.8393 mL 2.0983 mL
60 mM 0.0699 mL 0.3497 mL 0.6994 mL 1.7486 mL
80 mM 0.0525 mL 0.2623 mL 0.5246 mL 1.3114 mL
100 mM 0.0420 mL 0.2098 mL 0.4197 mL 1.0491 mL
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(Z)-Semaxanib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Z)-Semaxanib194413-58-6(Z)-SU5416c-Met/HGFRTAMH cellsHepG2 cellscytotoxicityInhibitorinhibitorinhibit

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