1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. cis-Urocanic acid

cis-Urocanic acid (Synonyms: (Z)-Urocanic acid; cis-UCA)

Cat. No.: HY-113008A
Handling Instructions

cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (Kd=4.6 nM). cis-Urocanic acid is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor.

For research use only. We do not sell to patients.

cis-Urocanic acid Chemical Structure

cis-Urocanic acid Chemical Structure

CAS No. : 7699-35-6

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10 mM * 1 mL in DMSO USD 289 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (Kd=4.6 nM). cis-Urocanic acid is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor[1].

IC50 & Target

5-HT2A Receptor

 

In Vitro

Treatment with 100 μg/mL cis-Urocanic acid (cis-UCA) completely suppresses IL-6 and IL-8 secretion, decreases caspase-3 activity, and improves cell viability against UV-B irradiation. No significant effects on IL-6 or IL-8 secretion, caspase-3 activity, or viability of the non-irradiated cells are observed with 100 μg/mL cis-Urocanic acid in both cell types. The 5000 μg/mL concentration is toxic[1].

Cell Viability Assay[1]

Cell Line: Human corneal epithelial cells (HCE-2) and human conjunctival epithelial cells (HCECs)
Concentration: 10, 100, 1,000, and 5,000 μg/mL
Incubation Time: 24, 48, or 72 hours
Result: Treatment with 100 μg/mL completely suppressed IL-6 and IL-8 secretion, decreased caspase-3 activity, and improved cell viability against UV-B irradiation. No significant effects on IL-6 or IL-8 secretion, caspase-3 activity, or viability of the non-irradiated cells were observed with 100 μg/mL in both cell types.
Molecular Weight

138.12

Formula

C₆H₆N₂O₂

CAS No.

7699-35-6

SMILES

O=C(O)/C=C\C1=CN=CN1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

cis-Urocanic acid(Z)-Urocanic acidcis-UCA5-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT2AimmunemodulatorimmunosuppressionregulationinflammationserotoninUVradiationInhibitorinhibitorinhibit

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cis-Urocanic acid
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HY-113008A
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