2. Metabolic Enzyme/Protease
  3. Liposome
  4. (Z)-KC02

(Z)-KC02 is an inhibitor of ABHD16A, the phosphatidylserine (PS) lipase that produces lyso-PS. Lysophosphatidylserine (lyso-PS) is a signaling lipid that regulates immune and neurological processes. It is associated with several neurological disorders such as retinitis pigmentosa and cataracts (PHARC). (Z)-KC02 depletes lyso-PS in lymphoblasts from PHARC subjects. (Z)-KC02 also reduces lyso-PS and lipopolysaccharide-induced cytokine production in macrophages and modulates lyso-PS metabolism in vivo.

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(Z)-KC02 Chemical Structure

(Z)-KC02 Chemical Structure

CAS No. : 1646795-60-9

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Based on 1 publication(s) in Google Scholar

(Z)-KC02 Related Antibodies

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Description

(Z)-KC02 is an inhibitor of ABHD16A, the phosphatidylserine (PS) lipase that produces lyso-PS. Lysophosphatidylserine (lyso-PS) is a signaling lipid that regulates immune and neurological processes. It is associated with several neurological disorders such as retinitis pigmentosa and cataracts (PHARC). (Z)-KC02 depletes lyso-PS in lymphoblasts from PHARC subjects. (Z)-KC02 also reduces lyso-PS and lipopolysaccharide-induced cytokine production in macrophages and modulates lyso-PS metabolism in vivo[1].

In Vitro

(Z)-KC02 disrupts ABHD16A in mouse macrophages, thereby reducing lyso-PS levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(Z)-KC02 Related Antibodies
Molecular Weight

287.35

Formula

C17H21NO3
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(N)CCCC/C=C1C(OC\1CCC2=CC=CC=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Purity & Documentation
References
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(Z)-KC02 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Z)-KC021646795-60-9Liposomelyso-PSsneurological disease polyneuropathyhearing lossataxiaretinitis pigmentosacataractPHARCInhibitorinhibitorinhibit

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