1646795-60-9
Chemical Structure
(Z)-KC02
- CAS. Nr.: 1646795-60-9
- Formula:C17H21NO3
- Molecular Weight:287.35
IUPAC Name: (Z)-6-(2-oxo-4-phenethyloxetan-3-ylidene)hexanamide
InChIKey: XWRBNJBEHUJLPT-ZROIWOOFSA-N
SMILES: O=C(N)CCCC/C=C1C(OC\1CCC2=CC=CC=C2)=O
Biological Activity: (Z)-KC02 is an inhibitor of ABHD16A, the phosphatidylserine (PS) lipase that produces lyso-PS. Lysophosphatidylserine (lyso-PS) is a signaling lipid that regulates immune and neurological processes. It is associated with several neurological disorders such as retinitis pigmentosa and cataracts (PHARC). (Z)-KC02 depletes lyso-PS in lymphoblasts from PHARC subjects. (Z)-KC02 also reduces lyso-PS and lipopolysaccharide-induced cytokine production in macrophages and modulates lyso-PS metabolism in vivo[1].
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(Z)-KC02 | (Z)-KC02 is an inhibitor of ABHD16A, the phosphatidylserine (PS) lipase that produces lyso-PS. Lysophosphatidylserine (lyso-PS) is a signaling lipid that regulates immune and neurological processes. It is associated with several neurological disorders such as retinitis pigmentosa and cataracts (PHARC). (Z)-KC02 depletes lyso-PS in lymphoblasts from PHARC subjects. (Z)-KC02 also reduces lyso-PS and lipopolysaccharide-induced cytokine production in macrophages and modulates lyso-PS metabolism in vivo. | |||||||||||||||||||||
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