(E/Z)-Farnesyl pyrophosphate
(E/Z)-Farnesyl pyrophosphate ((E/Z)-Farnesyl diphosphate), a 15-carbon isoprenoid, is a metabolic intermediate of the mevalonate (MVA) pathway. (E/Z)-Farnesyl pyrophosphate is a TRPM2 (TRP Channel) agonist, activates TRPM2 opening for ion influx. (E/Z)-Farnesyl pyrophosphate is a key branch substrate for cholesterol synthesis, ubiquinones synthesis, protein farnesylation decoration, and geranyl-geranyl pyrophosphate (GGPP) synthesis.
The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Farnesyl pyrophosphate ammonium) that retains the same biological activity.
For research use only. We do not sell to patients.
- CAS No.: 13058-04-3
- Formula: C15H28O7P2
- Molecular Weight:382.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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All Endogenous Metabolite Isoforms
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Biological Activity
Description
In Vitro
(E/Z)-Farnesyl pyrophosphate functions as an identified danger signal to trigger acute cell death leading to neuron loss in stroke. Harboring both a hydrophobic 15-carbon isoprenyl chain and a heavily charged pyrophosphate head, (E/Z)-Farnesyl pyrophosphate leads to acute cell death independent of its downstream metabolic pathways. Mechanistically, extracellular calcium influx and the cation channel transient receptor potential melastatin 2 (TRPM2) exhibit essential roles in (E/Z)-Farnesyl pyrophosphate-induced cell death. (E/Z)-Farnesyl pyrophosphate activates TRPM2 opening for ion influx[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 13058-04-3
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Molecular Weight 382.33
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Formula C15H28O7P2
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SMILES
O=P(O)(OP(O)(O)=O)OC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C
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Synonyms
(E/Z)-Farnesyl diphosphate
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(E/Z)-Farnesyl pyrophosphate Related Classifications
HY-113037 Related Classifications
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