1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK
  3. NSC 42834

NSC 42834 (Synonyms: JAK2 Inhibitor V; Z3)

Cat. No.: HY-15480 Purity: 96.79%
Handling Instructions

NSC 42834 (JAK2 Inhibitor V), a novel specific inhibitor of Jak2, inhibits Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner but was not cytotoxic to cells at concentrations that inhibited kinase activity.

For research use only. We do not sell to patients.

NSC 42834 Chemical Structure

NSC 42834 Chemical Structure

CAS No. : 195371-52-9

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10 mM * 1  mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
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10 mg USD 90 In-stock
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50 mg USD 350 In-stock
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100 mg USD 650 In-stock
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Description

NSC 42834 (JAK2 Inhibitor V), a novel specific inhibitor of Jak2, inhibits Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner but was not cytotoxic to cells at concentrations that inhibited kinase activity.

IC50 & Target[1]

JAK2-WT

15 μM (IC50)

JAK2-V617F

28 μM (IC50)

In Vitro

NSC 42834 (JAK2 Inhibitor V) selectively inhibited Jak2 kinase function with no effect on Tyk2 or c-Src kinase function. NSC 42834 significantly inhibited proliferation of the Jak2-V617F-expressing, human erythroleukemia cell line, HEL 92.1.7. The NSC 42834-mediated reduction in cell proliferation correlated with reduced Jak2 and STAT3 tyrosine phosphorylation levels as well as marked cell cycle arrest. Finally, NSC 42834 inhibited the growth of hematopoietic progenitor cells isolated from the bone marrow of an essential thrombocythemia patient harboring the Jak2-V617F mutation and a polycythemia vera patient carrying a Jak2-F537I mutation.

Molecular Weight

344.45

Formula

C₂₃H₂₄N₂O

CAS No.

195371-52-9

SMILES

O=C(C1=CC=CC=C1)C(CCC2=NC=CC=C2)(C)CCC3=NC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (290.32 mM)

Ethanol : 100 mg/mL (290.32 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9032 mL 14.5159 mL 29.0318 mL
5 mM 0.5806 mL 2.9032 mL 5.8064 mL
10 mM 0.2903 mL 1.4516 mL 2.9032 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.26 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.26 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.26 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

NSC 42834JAK2 Inhibitor VZ3NSC42834NSC-42834Z 3Z-3JAKJanus kinaseInhibitorinhibitorinhibit

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Product Name:
NSC 42834
Cat. No.:
HY-15480
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