195371-52-9
195371-52-9
Chemical Structure
NSC 42834
Synonym(s): JAK2 Inhibitor V; Z3
- CAS No.: 195371-52-9
- Formula:C23H24N2O
- Molecular Weight:344.45
IUPAC Name: 2-methyl-1-phenyl-4-(pyridin-2-yl)-2-(2-(pyridin-2-yl)ethyl)butan-1-one
InChIKey: SETYDCSRABYHSW-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC=C1)C(CCC2=NC=CC=C2)(C)CCC3=NC=CC=C3
Biological Activity: NSC 42834 (JAK2 Inhibitor V), a novel specific inhibitor of Jak2, inhibits Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner but was not cytotoxic to cells at concentrations that inhibited kinase activity.
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NSC 42834 | 96.85% | NSC 42834 (JAK2 Inhibitor V), a novel specific inhibitor of Jak2, inhibits Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner but was not cytotoxic to cells at concentrations that inhibited kinase activity. | ||||||||||||||||||||
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Keywords
