(Z)-9-Propenyladenine
Based on 1 Customer Validation
(Z)-9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate. Tenofovir is an antiretroviral agent known as nucleotide analogue reverse transcriptase (NtART) inhibitor, which blocks reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV.
For research use only. We do not sell to patients.
- Purity : 97.21%
- CAS No.: 1464851-21-5
- Formula: C8H9N5
- Molecular Weight:175.19
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-100079
9-Propenyladenine -
HY-B0250
Lamivudine -
HY-17427
Emtricitabine -
HY-90005
Etravirine -
HY-100079R
9-Propenyladenine (Standard) -
HY-B0250R
Lamivudine (Standard) -
HY-78726
Fosamprenavir -
HY-17427R
Emtricitabine (Standard) -
HY-90005R
Etravirine (Standard) -
HY-78726R
Fosamprenavir (Standard) -
HY-100096
Emtricitabine S-oxide
Biological Activity
Description
IC50 & Target
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HIV-1 |
Chemical Information
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CAS No. 1464851-21-5
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Appearance Solid
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Molecular Weight 175.19
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Formula C8H9N5
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Color White to off-white
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SMILES
NC1=C2N=CN(/C=C\C)C2=NC=N1
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Synonyms
(Z)-Mutagenic Impurity of Tenofovir Disoproxil
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
In Vitro:
DMSO : ≥ 100 mg/mL (570.81 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (14.27 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (14.27 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 5.7081 mL | 28.5404 mL | 57.0809 mL | 142.7022 mL |
| 5 mM | 1.1416 mL | 5.7081 mL | 11.4162 mL | 28.5404 mL | |
| 10 mM | 0.5708 mL | 2.8540 mL | 5.7081 mL | 14.2702 mL | |
| 15 mM | 0.3805 mL | 1.9027 mL | 3.8054 mL | 9.5135 mL | |
| 20 mM | 0.2854 mL | 1.4270 mL | 2.8540 mL | 7.1351 mL | |
| 25 mM | 0.2283 mL | 1.1416 mL | 2.2832 mL | 5.7081 mL | |
| 30 mM | 0.1903 mL | 0.9513 mL | 1.9027 mL | 4.7567 mL | |
| 40 mM | 0.1427 mL | 0.7135 mL | 1.4270 mL | 3.5676 mL | |
| 50 mM | 0.1142 mL | 0.5708 mL | 1.1416 mL | 2.8540 mL | |
| 60 mM | 0.0951 mL | 0.4757 mL | 0.9513 mL | 2.3784 mL | |
| 80 mM | 0.0714 mL | 0.3568 mL | 0.7135 mL | 1.7838 mL | |
| 100 mM | 0.0571 mL | 0.2854 mL | 0.5708 mL | 1.4270 mL |
(Z)-9-Propenyladenine Related Classifications
HY-100079A Related Classifications
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