1. Anti-infection
  2. HIV
    Reverse Transcriptase

Emtricitabine S-oxide (Synonyms: Emtricitabine sulfoxide; Emtricitabine Degradant-III)

Cat. No.: HY-100096
Handling Instructions

Emtricitabine Degradant-III is a major degradation product of Emtricitabine. Emtricitabine is a potent nucleoside reverse transcriptase inhibitor used for the treatment of HIV infection.

For research use only. We do not sell to patients.

Emtricitabine S-oxide Chemical Structure

Emtricitabine S-oxide Chemical Structure

CAS No. : 152128-77-3

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Emtricitabine Degradant-III is a major degradation product of Emtricitabine. Emtricitabine is a potent nucleoside reverse transcriptase inhibitor used for the treatment of HIV infection.

IC50 & Target[1]

Reverse Transcriptase

 

HIV

 

In Vitro

Emtricitabine, an antiretroviral agent is used to evaluate degradation pathways under different stress conditions in order to identify degradation products as prescribed by ICH guidelines. Emtricitabine degrades over 51%, 13% and 53% during acid, base and oxidative degradation respectively followed by formation of three major degradation products (Degradant-I to Degradant-III)[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7987 mL 18.9934 mL 37.9867 mL
5 mM 0.7597 mL 3.7987 mL 7.5973 mL
10 mM 0.3799 mL 1.8993 mL 3.7987 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

263.25

Formula

C₈H₁₀FN₃O₄S

CAS No.

152128-77-3

SMILES

O=C1N=C(N)C(F)=CN1[[email protected]@H](O[[email protected]]2CO)CS2=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Emtricitabine S-oxide
Cat. No.:
HY-100096
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Emtricitabine S-oxide

Cat. No.: HY-100096