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Cat. No.: HY-156375

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PKM2 activator 6

PKM2 activator 6 (Compound Z10) is a PKM2 activator and PDK1 inhibitor (K_D: 121 and 19.6 μM respectively). PKM2 activator 6 induces colorectal cell apoptosis, and inhibits cell proliferation and migration . PKM2 activator 6 inhibits glycolysis. PKM2 activator 6 inhibits proliferation of DLD-1, HCT-8, HT-29, MCF-10A cells (IC₅₀: 10.04, 2.16, 3.57, 66.39 μM).

For research use only. We do not sell to patients.

Formula: C₂₉H₃₁NO₁₀S₂
Molecular Weight:617.69

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

PKM2 activator 6 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
DLD-1	IC₅₀	10.04 μM Compound: 140	Antiproliferative activity against human DLD-1 cells assessed as inhibition of cell growth incubated for 96 hrs by CCK-8 assay Antiproliferative activity against human DLD-1 cells assessed as inhibition of cell growth incubated for 96 hrs by CCK-8 assay	[PMID: 38458106]
HCT-29	IC₅₀	3.57 μM Compound: 140	Antiproliferative activity against human HCT-29 cells assessed as inhibition of cell growth incubated for 96 hrs by CCK-8 assay Antiproliferative activity against human HCT-29 cells assessed as inhibition of cell growth incubated for 96 hrs by CCK-8 assay	[PMID: 38458106]
HCT-8	IC₅₀	2.16 μM Compound: 140	Antiproliferative activity against human HCT-8 cells assessed as inhibition of cell growth incubated for 96 hrs by CCK-8 assay Antiproliferative activity against human HCT-8 cells assessed as inhibition of cell growth incubated for 96 hrs by CCK-8 assay	[PMID: 38458106]

Chemical Information

Molecular Weight 617.69
Formula C₂₉H₃₁NO₁₀S₂
SMILES

O=C(OC)C(CS[C@@H](C(C1=O)=CC(C2=C1C(O)=CC=C2O)=O)C/C=C(C)\C)NC(C3=CC(S(=O)(C)=O)=CC=C3OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ma Y, et al. Design, synthesis and biological evaluation of novel modified dual-target shikonin derivatives for colorectal cancer treatment. Bioorg Chem. 2023 Oct;139:106703. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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