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Cat. No.: HY-162283

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FGFR4-IN-18

FGFR4-IN-18 (compound 8z) is an inhibitor of FGFR4 and can be used in cancer research.

For research use only. We do not sell to patients.

Formula: C₃₂H₃₅Cl₂N₉O₆
Molecular Weight:712.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (244 KB)

FGFR4-IN-18 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
Calculators
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Bioz

Biological Activity

Description

FGFR4-IN-18 (compound 8z) is an inhibitor of FGFR4 and can be used in cancer research^[1].

IC₅₀ & Target

FGFR4^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	>2000 nM Compound: 8z	Antiproliferative activity against mouse BaF3 cells assessed as inhibition of cell growth Antiproliferative activity against mouse BaF3 cells assessed as inhibition of cell growth	[PMID: 38348819]
BaF3	IC₅₀	1.2 nM Compound: 8z	Antiproliferative activity against mouse BaF3 cells harboring wild type FGFR4 assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against mouse BaF3 cells harboring wild type FGFR4 assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 38348819]
BaF3	IC₅₀	13.5 nM Compound: 8z	Antiproliferative activity against mouse BaF3 cells harboring FGFR4 V550L mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against mouse BaF3 cells harboring FGFR4 V550L mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 38348819]
BaF3	IC₅₀	64.5 nM Compound: 8z	Antiproliferative activity against mouse BaF3 cells harboring FGFR4 V550M mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against mouse BaF3 cells harboring FGFR4 V550M mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 38348819]
HEK293	IC₅₀	>2000 nM Compound: 8z	Cytotoxicity against HEK293 cells assessed as inhibition of cell growth Cytotoxicity against HEK293 cells assessed as inhibition of cell growth	[PMID: 38348819]
Hep 3B2	IC₅₀	15 nM Compound: 8z	Antiproliferative activity against human Hep3B cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human Hep3B cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 38348819]
Huh-7	IC₅₀	20.4 nM Compound: 8z	Antiproliferative activity against FGF19/FGFR4 dependent human Huh-7 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against FGF19/FGFR4 dependent human Huh-7 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 38348819]

Chemical Information

Molecular Weight 712.58
Formula C₃₂H₃₅Cl₂N₉O₆
SMILES

O=C(NC1=NC(C=O)=C(C=C1OCCN2CCOCC2)CN3C(CN(CC3)C)=O)NC4=CC(O[C@@H](C5=C(C=NC=C5Cl)Cl)C)=C(C=N4)C#N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.