FGFR4-IN-18
FGFR4-IN-18 (compound 8z) is an inhibitor of FGFR4 and can be used in cancer research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C32H35Cl2N9O6
- Molecular Weight:712.58
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
FGFR4[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | IC50 |
>2000 nM
Compound: 8z
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Antiproliferative activity against mouse BaF3 cells assessed as inhibition of cell growth
Antiproliferative activity against mouse BaF3 cells assessed as inhibition of cell growth
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[PMID: 38348819] |
| BaF3 | IC50 |
1.2 nM
Compound: 8z
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Antiproliferative activity against mouse BaF3 cells harboring wild type FGFR4 assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against mouse BaF3 cells harboring wild type FGFR4 assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
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[PMID: 38348819] |
| BaF3 | IC50 |
13.5 nM
Compound: 8z
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Antiproliferative activity against mouse BaF3 cells harboring FGFR4 V550L mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against mouse BaF3 cells harboring FGFR4 V550L mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
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[PMID: 38348819] |
| BaF3 | IC50 |
64.5 nM
Compound: 8z
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Antiproliferative activity against mouse BaF3 cells harboring FGFR4 V550M mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against mouse BaF3 cells harboring FGFR4 V550M mutant assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
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[PMID: 38348819] |
| HEK293 | IC50 |
>2000 nM
Compound: 8z
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Cytotoxicity against HEK293 cells assessed as inhibition of cell growth
Cytotoxicity against HEK293 cells assessed as inhibition of cell growth
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[PMID: 38348819] |
| Hep 3B2 | IC50 |
15 nM
Compound: 8z
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Antiproliferative activity against human Hep3B cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human Hep3B cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
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[PMID: 38348819] |
| Huh-7 | IC50 |
20.4 nM
Compound: 8z
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Antiproliferative activity against FGF19/FGFR4 dependent human Huh-7 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against FGF19/FGFR4 dependent human Huh-7 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
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[PMID: 38348819] |
Chemical Information
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Molecular Weight 712.58
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Formel C32H35Cl2N9O6
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SMILES
O=C(NC1=NC(C=O)=C(C=C1OCCN2CCOCC2)CN3C(CN(CC3)C)=O)NC4=CC(O[C@@H](C5=C(C=NC=C5Cl)Cl)C)=C(C=N4)C#N
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
FGFR4-IN-18 Related Classifications
HY-162283 Related Classifications
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