2. Antibody-drug Conjugate/ADC Related GPCR/G Protein MAPK/ERK Pathway
  3. Drug-Linker Conjugates for ADC Ras
  4. Z52-L16

Z52-L16 is Drug-Linker Conjugates for ADC, which is composed of a linker and a Ras inhibitor Z52 (HY-178842). Z52-L16 can be used for the research of cancer, such as pancreatic cancer.

For research use only. We do not sell to patients.

Z52-L16

Z52-L16 Chemical Structure

CAS No. : 3077488-80-0

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25 mg Get quote 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks
50 mg Get quote 2 - 3 weeks 1 - 2 Weeks 3 - 4 weeks 2 - 3 weeks
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Customer Review

Based on 1 publication(s) in Google Scholar

Z52-L16 Related Antibodies

Top Publications Citing Use of Products

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Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

View All Ras Isoform Specific Products:

View All Isoforms
K-Ras H-Ras N-Ras Ras

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Z52-L16 is Drug-Linker Conjugates for ADC, which is composed of a linker and a Ras inhibitor Z52 (HY-178842). Z52-L16 can be used for the research of cancer, such as pancreatic cancer[1].

Molecular Weight

2707.08

Formula

C130H196N14O45S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC1(CNC(OCC2=CC=C(O[C@@H]3O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]3O)C(NC(CCNC([C@@H](NC(CCN4C(C=CC4=O)=O)=O)CCCCNC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)=O)=C2)=O)CCN(CC1)CC#CC5=C[C@@]([C@@]6=C7C8=CC(C9=CSC(C[C@H](NC([C@@H]%10[C@H]%11COC[C@@H]%10%11)=O)C(N%12N[C@H](C(OCC(C7)(C)C)=O)CCC%12)=O)=N9)=CC=C8N6CC)=C(N=C5)[C@@H](OC)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (36.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3694 mL 1.8470 mL 3.6940 mL
5 mM 0.0739 mL 0.3694 mL 0.7388 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.3694 mL 1.8470 mL 3.6940 mL 9.2350 mL
5 mM 0.0739 mL 0.3694 mL 0.7388 mL 1.8470 mL
10 mM 0.0369 mL 0.1847 mL 0.3694 mL 0.9235 mL
15 mM 0.0246 mL 0.1231 mL 0.2463 mL 0.6157 mL
20 mM 0.0185 mL 0.0924 mL 0.1847 mL 0.4618 mL
25 mM 0.0148 mL 0.0739 mL 0.1478 mL 0.3694 mL
30 mM 0.0123 mL 0.0616 mL 0.1231 mL 0.3078 mL
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Z52-L16 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z52-L163077488-80-0Drug-Linker Conjugates for ADCRasCancerpancreatic cancerdrug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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