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Results for "

3i7g 5uwm mmp Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	MMP (203) Akt (8) Aminopeptidase (1) Amyloid-β (1) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (10) AP-1 (2) Apoptosis (39) Atg8/LC3 (1) Autophagy (6) Bacterial (15) Bcl-2 Family (2) Biochemical Assay Reagents (2) Caspase (2) Cathepsin (3) CDK (3) Chloride Channel (1) Cholinesterase (ChE) (2) COX (5) Deubiquitinase (1) Drug Metabolite (1) EBI2/GPR183 (1) EGFR (2) Endogenous Metabolite (8) ERK (4) FAK (3) Fluorescent Dye (5) Fungal (2) Glucocorticoid Receptor (2) HIV (3) HIV Integrase (1) HIV Protease (3) HSV (2) iGluR (1) Interleukin Related (3) Isotope-Labeled Compounds (4) JNK (3) Keap1-Nrf2 (1) Leukotriene Receptor (1) MALT1 (1) MDM-2/p53 (1) Microtubule/Tubulin (2) Mitochondrial Metabolism (2) Mixed Lineage Kinase (2) mTOR (4) NF-κB (11) NO Synthase (3) Nucleoside Antimetabolite/Analog (1) Oxidative Phosphorylation (2) P-glycoprotein (1) P2Y Receptor (1) p38 MAPK (6) Parasite (7) PARP (1) PI3K (4) PKC (1) PPAR (1) Procollagen C Proteinase (1) Proteasome (1) Pyroptosis (1) Ras (1) Reactive Oxygen Species (9) RIP kinase (2) SARS-CoV (4) Small Interfering RNA (siRNA) (44) Src (1) TGF-beta/Smad (1) TNF Receptor (6) Toll-like Receptor (TLR) (2) VEGFR (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (146) Cardiovascular Disease (15) Endocrinology (5) Infection (22) Inflammation/Immunology (71) Metabolic Disease (13) Neurological Disease (13)

By Targets:

MMP (203)

Akt (8)

Aminopeptidase (1)

Amyloid-β (1)

Angiotensin-converting Enzyme (ACE) (2)

Antibiotic (10)

AP-1 (2)

Apoptosis (39)

Atg8/LC3 (1)

Autophagy (6)

Bacterial (15)

Bcl-2 Family (2)

Biochemical Assay Reagents (2)

Caspase (2)

Cathepsin (3)

CDK (3)

Chloride Channel (1)

Cholinesterase (ChE) (2)

COX (5)

Deubiquitinase (1)

Drug Metabolite (1)

EBI2/GPR183 (1)

EGFR (2)

Endogenous Metabolite (8)

ERK (4)

FAK (3)

Fluorescent Dye (5)

Fungal (2)

Glucocorticoid Receptor (2)

HIV (3)

HIV Integrase (1)

HIV Protease (3)

HSV (2)

iGluR (1)

Interleukin Related (3)

Isotope-Labeled Compounds (4)

JNK (3)

Keap1-Nrf2 (1)

Leukotriene Receptor (1)

MALT1 (1)

MDM-2/p53 (1)

Microtubule/Tubulin (2)

Mitochondrial Metabolism (2)

Mixed Lineage Kinase (2)

mTOR (4)

NF-κB (11)

NO Synthase (3)

Nucleoside Antimetabolite/Analog (1)

Oxidative Phosphorylation (2)

P-glycoprotein (1)

P2Y Receptor (1)

p38 MAPK (6)

Parasite (7)

PARP (1)

PI3K (4)

PKC (1)

PPAR (1)

Procollagen C Proteinase (1)

Proteasome (1)

Pyroptosis (1)

Ras (1)

Reactive Oxygen Species (9)

RIP kinase (2)

SARS-CoV (4)

Small Interfering RNA (siRNA) (44)

Src (1)

TGF-beta/Smad (1)

TNF Receptor (6)

Toll-like Receptor (TLR) (2)

VEGFR (1)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (146)

Cardiovascular Disease (15)

Endocrinology (5)

Infection (22)

Inflammation/Immunology (71)

Metabolic Disease (13)

Neurological Disease (13)

301

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: MMP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153563

MMP-7-IN-2

MMP Others

MMP-7-IN-2 (compound 16) is a selective inhibitor of MMP7 with an IC₅₀ value of 16 nM .

MMP-7-IN-2	MMP	Others
MMP-7-IN-2 (compound 16) is a selective inhibitor of *MMP7* with an IC₅₀ value of 16 nM .

HY-147745

MMP2-IN-2	MMP	Cancer
MMP2-IN-2 (compound 42) is a potent and selective *MMP-2* (matrix metalloproteinases) inhibitor, with an IC₅₀ of 4.2 μM. MMP2-IN-2 also shows inhibitory activity against *MMP-13, MMP-9* and *MMP-8, with IC₅₀* values of 12, 23.3, and 25 μM, respectively .

HY-P2179

MMP-1/MMP-9 Substrate, Fluorogenic

Fluorescent Dye MMP Others

MMP-1/MMP-9 Substrate, Fluorogenic is a fluorogenic substrate for MMP-1 and MMP-9 .Ex/Em = 340/440 nm

MMP-1/MMP-9 Substrate, Fluorogenic	Fluorescent Dye MMP	Others
MMP-1/MMP-9 Substrate, Fluorogenic is a fluorogenic substrate for MMP-1 and MMP-9 .Ex/Em = 340/440 nm

HY-119423

MMP Inhibitor II	MMP	Cancer
MMP Inhibitor II (compound 4e) is a potent, reversible pan-MMP inhibitor with IC₅₀ values of 24 nM, 18.4 nM, 30 nM, and 2.7 nM for MMP-1,MMP-3, MMP-7, and MMP-9, respectively .

HY-P2166

MMP3 inhibitor 3

MMP Cancer

MMP3 inhibitor 3 is an inhibitor of MMP3. MMP3 inhibitor 3 can used to study breast cancer .

MMP3 inhibitor 3	MMP	Cancer
MMP3 inhibitor 3 is an inhibitor of *MMP3. MMP*3 inhibitor 3 can used to study breast cancer .

HY-161284

MMP-9/10-IN-1	MMP	Cancer
MMP-9/10-IN-1 (Compound 6b) is a potent dual *MMP-9/10* Inhibotor with IC₅₀s of 0.076 and 0.139 μM against NSCLC and A549 cells, respectively. MMP-9/10-IN-1 has anti-invasive and anti-angiogenic activities when in combination with Sorafenib (HY-10201) .

HY-156430

MMP-7-IN-3	MMP	Cancer
MMP-7-IN-3 is a potent and selective inhibitor of *MMP-7. MMP*-7-IN-3 suppresses kidney fibrosis progression in a mouse model with unilateral ureteral obstruction .

HY-146754

MMP2-IN-1	MMP Apoptosis	Cancer
MMP2-IN-1 is a moderate potenet *MMP2* inhibitor with IC₅₀ of 6.8 µM. MMP2-IN-1 exhibits remarkable antiproliferative activity in certain cancer cells by arresting the cell cycle and inducing apoptosis .

HY-146006

*Tubulin/MMP-IN-1*	Microtubule/Tubulin MMP	Cancer
Tubulin/MMP-IN-1 (compound 15g) is a potent inhibitor of tubulin and *MMP. Tubulin/MMP-IN-1 has the potential for the research of cancer diseases. Tubulin/MMP*-IN-1 suppresses tubulin polymerization, induces cell cycle arrest at the G2/M phase, leads to reactive oxidative stress (ROS) generation of HepG2 cells, and results in apoptosis by the mitochondrial-dependent apoptotic pathway .

HY-128026

MMP-9/MMP-13 Inhibitor I	MMP	Inflammation/Immunology
MMP-9/MMP-13 Inhibitor I is a potent *MMP-9* and *MMP-13* inhibitor with IC₅₀s of both 0.9 nM. MMP-9/MMP-13 Inhibitor I shows >20-folds selectivity for MMP-9/MMP-13 over other MMPs .

HY-116399

MMP-2/MMP-9-IN-1	MMP	Cancer
MMP-2/MMP-9-IN-1 is a highly selective, orally active and potent type IV collagenase (MMP-9 and *MMP-2) inhibitor with IC₅₀s of 0.24 and 0.31 μM for MMP-9 and MMP-2, respectively. MMP-2/MMP-9-IN-1 is orally active in animal models of tumor growth and metastasis. MMP-2/MMP*-9-IN-1 can be used for the research of cancer .

HY-P2682

MMP-8/MMP-26 Fluorogenic substrate	MMP	Metabolic Disease
MMP-8/MMP-26 Fluorogenic substrate (DNP-Pro-Leu-Ala-Tyr-Trp-Ala-Arg) is a matrix metalloproteinase-8 (MMP-8) fluorogenic substrate. MMP-8/MMP-26 Fluorogenic substrate can be used for the research of atherosclerosis, pulmonary fibrosis, and sepsis .

HY-128133

MMP-8 inhibitor-1

mmp8-I
MMP Cancer

MMP-8 inhibitor-1 (compound 21), a hydroxamic acid derivative, is a potent MMP-8 inhibitor without significant oral bioavailability .
HY-P2414

MMP-13 Substrate

MMP Inflammation/Immunology

MMP-13 Substrate is a substrate of MMP-13. MMP-13 Substrate can be used for the research of osteoarthritis (OA) .
HY-14155

MMP145

MMP Inflammation/Immunology

MMP145 (compound 27) is a potent, selective and orally active MMP-12 inhibitor. MMP145 is effective in inflammation and asthma reasearch .

MMP-8 inhibitor-1 mmp8-I	MMP	Cancer
MMP-8 inhibitor-1 (compound 21), a hydroxamic acid derivative, is a potent *MMP-8* inhibitor without significant oral bioavailability .

MMP-13 Substrate	MMP	Inflammation/Immunology
MMP-13 Substrate is a substrate of MMP-13. MMP-13 Substrate can be used for the research of osteoarthritis (OA) .

MMP145	MMP	Inflammation/Immunology
MMP145 (compound 27) is a potent, selective and orally active *MMP-12* inhibitor. MMP145 is effective in inflammation and asthma reasearch .

HY-116302

MMP-9-IN-9	MMP	Neurological Disease Inflammation/Immunology
MMP-9-IN-9 (compound 4f) is a slective *MMP-9* inhibitor with an IC₅₀ of 5 nM. MMP-9-IN-9 shows selective for MMP-9 over MMP-1 and MMP-13. MMP-9-IN-9 shows strong anti-inflammatory and neuroprotective effects .

HY-130076

MMP-2 Inhibitor II	MMP	Cancer
MMP-2 Inhibitor II (compound 2) is a selective *MMP-2* inhibitor. The Kinetic parameters for MMP inhibition are 2.4 μM (MMP-2), 45 μM (MMP-1), and 379 μM (MMP-7), respectively .

HY-146218

MMP-9-IN-5	MMP Akt Apoptosis	Cancer
MMP-9-IN-5 is a *MMP-9* inhibitor (IC₅₀: 4.49 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-5 also inhibits _AKT activity (IC₅₀: 1.34 nM). MMP-9-IN-5 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-5 can be used in the research of cancers .

HY-146216

MMP-9-IN-3	MMP Akt Apoptosis	Cancer
MMP-9-IN-3 is a *MMP-9* inhibitor (IC₅₀: 5.56 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-3 also inhibits AKT activity (IC₅₀: 2.11 nM). MMP-9-IN-3 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-3 can be used in the research of cancers .

HY-147746

MMP2-IN-3	MMP	Cancer
MMP2-IN-3 (compound 2) is a potent *MMP-2* (matrix metalloproteinases) inhibitor, with an IC₅₀ of 31 μM. MMP2-IN-3 also shows inhibitory activity against *MMP-9* and *MMP-8, with IC₅₀* values of 26.6, and 32 μM, respectively .

HY-146217

MMP-9-IN-4	MMP Akt Apoptosis	Cancer
MMP-9-IN-4 is a *MMP-9* inhibitor (IC₅₀: 7.46 nM) that has H-π interactions with MMP-9. MMP-9-IN-4 also inhibits _AKT activity (IC₅₀: 8.82 nM). MMP-9-IN-4 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-4 can be used in the research of cancers .

HY-153913

MMP-9-IN-7	MMP	Inflammation/Immunology
MMP-9-IN-7 is a potent *MMP9* inhibitor with an IC₅₀ of 0.52 μM in proMMP9/MMP3 P126 activation assay. MMP-9-IN-7 is extracted from patent WO2012162468 (example 59), and can be used for MMP9/MMP13 mediated syndrome research .

HY-135232

MMP-9-IN-1 5 Publications Verification	MMP	Cancer
MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor, which selectively target the hemopexin (PEX) domain of MMP-9, but not other MMPs .

HY-151540

MMP-7-IN-1	MMP	Cancer
MMP-7-IN-1 is a potent and selective inhibitor of *MMP-7* over MMP-1, -2, -3, -8, -9, -13 with an IC₅₀ value of 10 nM. MMP-7 is a potential target for diseases including cancer and fibrosis .

HY-122624

MMP13-IN-2	MMP	Inflammation/Immunology
MMP13-IN-2 is a potent, selective and orally active *MMP-13* inhibitor. MMP13-IN-2 exhibits excellent potency for MMP-13 (IC₅₀=0.036 nM) and selectivities (greater than 1,500-fold) over MMP-1, 3, 7, 8, 9, 14, and TACE. MMP13-IN-2 has the ability to block the release of collagen from cartilage in vitro. MMP13-IN-2 has the potential for collagenase related disease research .

HY-154868

MMP-13-IN-1	MMP	Cardiovascular Disease Cancer
MMP-13-IN-1 is a potent and selective inhibitor of *MMP-13* with a IC₅₀ value of 16 nM. MMP-13-in-1 can be used for atherosclerosis research .

HY-152030

*Tubulin/MMP-IN-2*	Microtubule/Tubulin MMP Apoptosis	Cancer
Tubulin/MMP-IN-2 is dual inhibitor of tubulin and matrix metalloproteinases. Tubulin/MMP-IN-2 can strongly inhibit tubulin polymerization and induces cell apoptosis. Tubulin/MMP-IN-2 has inhibitory activities against MMP-2, MMP-3 and MMP-9 with IC₅₀ values of 24.95 μM, 31.60 μM and 22.37 μM, respectively. Tubulin/MMP-IN-2 can be used for the research of cancer .

HY-112546

MMP-2 Inhibitor I

MMP Cancer

MMP-2 Inhibitor I (OA-Hy) is a potent MMP-2 inhibitor with a K_i of 1.7 μM .

MMP-2 Inhibitor I	MMP	Cancer
MMP-2 Inhibitor I (OA-Hy) is a potent MMP-2 inhibitor with a K_i of 1.7 μM .

HY-110046

CL-82198 hydrochloride	MMP	Others
CL-82198 hydrochloride is a selective inhibitor of *MMP-13. CL-82198 hydrochloride binds to the entire S1’ pocket of MMP-13, which is the basis of its selectivity against MMP-1, MMP*-9, and TACE .

HY-149378

MMP13-IN-5

MMP Metabolic Disease

MMP13-IN-5 (compound 13m) is a potent and selective inhibitor of MMP-2/MMP-13 (IC₅₀=3.6 μM/14.6 μM)，involved in osteoarthritis (OA) .
HY-152092

MMP-1-IN-1

MMP Cancer

MMP-1-IN-1 (Compound 6) is a highly potent MMP-1 inhibitor with an IC₅₀ of 0.034 μM .

MMP13-IN-5	MMP	Metabolic Disease
MMP13-IN-5 (compound 13m) is a potent and selective inhibitor of *MMP-2/MMP-13* (IC₅₀=3.6 μM/14.6 μM)，involved in osteoarthritis (OA) .

MMP-1-IN-1	MMP	Cancer
MMP-1-IN-1 (Compound 6) is a highly potent *MMP-1* inhibitor with an IC₅₀ of 0.034 μM .

HY-130391

MMP12-IN-3	MMP	Inflammation/Immunology
MMP12-IN-3 (compound 32) is a potent *MMP12* inhibitor with an IC₅₀ value of 4.9 nM. MMP12-IN-3 has the potential for the research of chronic respiratory diseases such as emphysema .

HY-161285

MMP-9/10-IN-2	MMP	Cancer
MMP-9/10-IN-2 (compound 6e) is a potent inhibitor of *MMP10 and MMP9, with IC₅₀* of 0.076 μM for *MMP*10, and 93.18% inhibition at 0.5 μM for *MMP9. MMP*-9/10-IN-2 plays an important role in anti-tumor .

HY-149377

MMP13-IN-4

MMP Metabolic Disease

MMP13-IN-4 (compound 13) is a potent and selective inhibitor of MMP-13 (IC₅₀=14.6 μM)，involved in osteoarthritis (OA) .
HY-149848

MMP-9-IN-6

MMP Inflammation/Immunology

MMP-9-IN-6 (Compound 3g) is a MMP-9 inhibitor with IC₅₀ value of 50 μM, which has good anti-ulcer effect .

MMP13-IN-4	MMP	Metabolic Disease
MMP13-IN-4 (compound 13) is a potent and selective inhibitor of *MMP-13* (IC₅₀=14.6 μM)，involved in osteoarthritis (OA) .

MMP-9-IN-6	MMP	Inflammation/Immunology
MMP-9-IN-6 (Compound 3g) is a *MMP-9* inhibitor with IC₅₀ value of 50 μM, which has good anti-ulcer effect .

HY-147867

MMP-2/9-IN-1	MMP	Cancer
MMP-2/9-IN-1 (Compound 4a) is a potent dual *MMP-2* and *MMP-9* inhibitor with IC₅₀ values of 56 nM and 38 nM, respectively. MMP-2/9-IN-1 inhibits tumor growth, strongly induces cancer cell apoptosis, inhibits cell migration, and suppresses cell cycle progression leading to DNA fragmentation .

HY-157138

MMP-9-IN-8	Others	Cancer
MMP-9-IN-8 (Compound 3) is an MMP-9 inhibitor with inhibitory activities of 42.16% and 58.28% at 10 μM and 50 μM concentrations, respectively. MMP-9-IN-8 has anti-cancer activity and can induce apoptosis in MCF-7 cells with an IC₅₀ value of 23.42 μM .

HY-162039

MMP-11-IN-1

MMP Cancer

MMP-11-IN-1 (compound 9) is a new class of phosphinate prodrug. MMP-11-IN-1 is a glycosyl ester of RXP03 and improves blood–brain barrier (BBB) behavior .
HY-114418

MMP3 inhibitor 1

1 Publications Verification

MMP Cancer

MMP3 inhibitor 1 is a potent and highly selective MMP-3 inhibitor with an IC₅₀ of 1 nM .

MMP-11-IN-1	MMP	Cancer
MMP-11-IN-1 (compound 9) is a new class of phosphinate prodrug. MMP-11-IN-1 is a glycosyl ester of RXP03 and improves blood–brain barrier (BBB) behavior .

MMP3 inhibitor 1 1 Publications Verification	MMP	Cancer
MMP3 inhibitor 1 is a potent and highly selective *MMP-3* inhibitor with an IC₅₀ of 1 nM .

HY-124029

BI-4394 mmp13-IN-3	MMP	Inflammation/Immunology
BI-4394 (MMP13-IN-3) is a potent, selective, and orally active *MMP-13* inhibitor (IC₅₀=1 nM ) for the potential treatment of osteoarthritis . BI-4394 is >1000 selective over other MMPs .

HY-156247

IVMT-Rx-3	NF-κB MMP	Cancer
IVMT-Rx-3 is a inhibitor of SDCBP targeting of the PDZ1 and PDZ2 Domains of MDA-9/Syntenin. IVMT-Rx-3 blocks MDA-9/Syntenin interaction with Src, reduces NF-κB activation, and inhibits *MMP-2/MMP-9* expression. IVMT-Rx-3 inhibits Melanoma Metastasis ^[1]

HY-14240

PG 116800 PG 530742; PGE 530742; PGE 7113313	MMP	Inflammation/Immunology
PG 116800 (PG 530742) is an orally avtive *MMP* inhibitor. PG 116800 has high affinity for MMP-2, -3, -8, -9, -13, and -14, while having substantially lower affinity for MMP-1 and -7. PG 116800 can be used for knee osteoarthritis research .

HY-107428

PD-166793	MMP	Cardiovascular Disease
PD-166793 is a potent, selective, orally active and wide‐broad spectrum inhibitor of *MMP, exhibiting nanomolar potency against MMP-2, MMP-3* and *MMP-13* (IC₅₀=4, 7, and 8 nM, respectively) and micromolar potency vs *MMP-1, -7 and -9 (IC₅₀*=6.0, 7.2, and 7.9 μM, respectively). PD-166793 can attenuate left ventricular remodeling and dysfunction in a rat model of progressive heart failure .

HY-RS08516

MMP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MMP1 Human Pre-designed siRNA Set A contains three designed siRNAs for MMP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MMP1 Human Pre-designed siRNA Set A MMP1 Human Pre-designed siRNA Set A

HY-RS08517

Mmp1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mmp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mmp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mmp1 Rat Pre-designed siRNA Set A Mmp1 Rat Pre-designed siRNA Set A

HY-RS08518

MMP10 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MMP10 Human Pre-designed siRNA Set A contains three designed siRNAs for MMP10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MMP10 Human Pre-designed siRNA Set A MMP10 Human Pre-designed siRNA Set A

HY-RS08519

Mmp10 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mmp10 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mmp10 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mmp10 Mouse Pre-designed siRNA Set A Mmp10 Mouse Pre-designed siRNA Set A

HY-RS08520

Mmp10 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mmp10 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mmp10 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mmp10 Rat Pre-designed siRNA Set A Mmp10 Rat Pre-designed siRNA Set A

HY-RS08521

MMP11 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MMP11 Human Pre-designed siRNA Set A contains three designed siRNAs for MMP11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MMP11 Human Pre-designed siRNA Set A MMP11 Human Pre-designed siRNA Set A

HY-RS08522

MMP12 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MMP12 Human Pre-designed siRNA Set A contains three designed siRNAs for MMP12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MMP12 Human Pre-designed siRNA Set A MMP12 Human Pre-designed siRNA Set A

Cat. No.	Product Name

HY-L185

Anti-Fibrosis Compound Library

852 compounds

Fibrosis is a kind of repair response to long-term tissue damage, which is mainly manifested by excessive deposition of extracellular matrix (ECM) and scar formation. Myofibroblasts are the main generating cells of extracellular matrix, and their activation process is related to various pathological mechanisms including Oxidative stress, chronic inflammation and cytokine secretion. Fibrosis can occur in many organs, such as kidneys, liver, heart, lungs, etc. Continuous fibrosis can lead to the destruction of the normal structure of tissues and organs, and if not controlled in time, may cause organ failure or even life-threatening.

MCE contains 852 compounds targeting ant-fibrosis targets such as TGF-β, PI3K, Wnt, MMP, etc. These compounds have clear or potential anti-fibrosis activity and can be used for mechanism research and drug screening of fibrosis diseases.

HY-L012

Metabolism/Protease Compound Library

4,475 compounds

Metabolism is the set of life-sustaining chemical reactions in organisms. Metabolic pathways are enzyme-mediated biochemical reactions that lead to biosynthesis (anabolism) or breakdown (catabolism) of natural product small molecules within a cell or tissue. Acting as catalysts, enzymes are crucial to metabolism - they allow a reaction to proceed more rapidly - and they also allow the regulation of the rate of a metabolic reaction. Proteases are used throughout an organism for various metabolic processes. Proteases control a great variety of physiological processes that are critical for life, including the immune response, cell cycle, cell death, wound healing, food digestion, and protein and organelle recycling. Imbalances in metabolic activities have been found to be critical in a number of pathologies, such as cardiovascular diseases, inflammation, cancer, and neurodegenerative diseases.

MCE designs a unique collection of 4,475 Metabolism/Protease-related small molecules that act as a useful tool for drug discovery of metabolism-related diseases.

Cat. No.	Product Name	Type

HY-131498

MOCAc-PLGL(Dpa)AR	Fluorescent Dyes/Probes
MOCAc-PLGL(Dpa)AR is a positively charged fluorescent substrate for matrix metalloproteinase-2 (MMP-2) and *MMP-7*. MOCAc-PLGL(Dpa)AR is a substrate of matrilysin, can be cleaved at the peptide bond between the glycine and leucine residues .

HY-P3474

Mca-Pro-Leu-Gly-Leu-Dap-Ala-Arg-NH2

Fluorescent Dyes/Probes

Mca-Pro-Leu-Gly-Leu-Dap-Ala-Arg-NH2 is a fluorescent peptide MMP substrate .

HY-P3098

Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2	Chromogenic Substrates
Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26. Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 can be used to quantify MMP-1, MMP-3 and MMP-26 activity .

HY-P3484

Dnp-PLGLWA-DArg-NH2 TFA	Fluorescent Dyes/Probes
Dnp-PLGLWA-DArg-NH2 TFA is a fluorogenic substrate for MMP-1 and MMP-9. Dnp-PLGLWA-DArg-NH2 TFA can be used to quantify the activity of MMPs (Ex=280 nm, Em=360 nm) .

HY-W277900

2-Methoxy-2,4-diphenylfuran-3-one	Fluorescent Dyes/Probes
2-Methoxy-2,4-diphenylfuran-3-one is a fluorescent compound which can be used to label gelatin as a substrate for detection of the gelatin degrading *MMP-2* and *MMP-9* by zymography .

HY-P2185

NFF-3	Dyes
NFF-3, the peptide, is a selective MMP substrate. NFF-3 selectively binds to *MMP-3* and *MMP-10* to be hydrolyzed. NFF-3 is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .

HY-P3120

Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2	Chromogenic Substrates
Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14).

HY-W127716

Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2	Fluorescent Dyes/Probes
Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 is a potent ruthenium-based dye. Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 can bu used as an effective quencher of quantum dots (QDs) fluorescence and the capture probe of virus antigen EV71. Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 can be used sensitive electrogenerated chemiluminescence (ECL) labels for detection of matrix metalloproteinases (MMPs) .

Cat. No.	Product Name	Type

HY-148905

p-Aminophenylmercuric acetate

Biochemical Assay Reagents

p-Aminophenylmercuric acetate is an organomercurial activator of matrix metalloproteinases (MMP). P-Aminophenylmercuric acetate participates in the activation and inhibition of MMP-8 by attacking protein sulfhydryl or inducing cysteine switching reaction. p-Aminophenylmercuric acetate promotes the shedding of betacellulin precursor (pro-BTC). p-Aminophenylmercuric acetate influences the binding of agonists and antagonists to the opiate receptor .

HY-W068119A

N-(2-Aminoethyl)maleimide hydrochloride 2-Maleimidoethylamine hydrochloride	Biochemical Assay Reagents
N-(2-Aminoethyl)maleimide (2-Maleimidoethylamine) hydrochloride is a cross-linker. N-(2-Aminoethyl)maleimide hydrochloride can be used to prepare MMP-2 sensitive nanosystem, and for cancer research .

HY-W016412

Coenzyme Q0

2 Publications Verification

CoQ0

Biochemical Assay Reagents

Coenzyme Q0 (CoQ0) is a potent, oral active ubiquinone compound can be derived from Antrodia cinnamomea. Coenzyme Q0 induces apoptosis and autophagy, suppresses of HER-2/AKT/mTOR signaling to potentiate the apoptosis and autophagy mechanisms. Coenzyme Q0 regulates NFκB/AP-1 activation and enhances Nrf2 stabilization in attenuation of inflammation and redox imbalance. Coenzyme Q0 has anti-angiogenic activity through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling .

HY-Y1841

o-Phenanthroline monohydrate 2 Publications Verification 1,10-Phenanthroline monohydrate	Biochemical Assay Reagents
o-Phenanthroline (1,10-Phenanthroline) monohydrate, a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline monohydrate forms a red chelate with Fe ²⁺ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) monohydrate is also a *MMP* inhibitor .

HY-W004544

o-Phenanthroline 2 Publications Verification 1,10-Phenanthroline	Biochemical Assay Reagents
o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe ²⁺ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a *MMP* inhibitor .

Cat. No.	Product Name	Target	Research Area

HY-153563

MMP-7-IN-2

MMP Others

MMP-7-IN-2 (compound 16) is a selective inhibitor of MMP7 with an IC₅₀ value of 16 nM .

HY-156430

MMP-7-IN-3	MMP	Cancer
MMP-7-IN-3 is a potent and selective inhibitor of *MMP-7. MMP*-7-IN-3 suppresses kidney fibrosis progression in a mouse model with unilateral ureteral obstruction .

HY-P2179

MMP-1/MMP-9 Substrate, Fluorogenic

Fluorescent Dye MMP Others

MMP-1/MMP-9 Substrate, Fluorogenic is a fluorogenic substrate for MMP-1 and MMP-9 .Ex/Em = 340/440 nm
HY-P2166

MMP3 inhibitor 3

MMP Cancer

MMP3 inhibitor 3 is an inhibitor of MMP3. MMP3 inhibitor 3 can used to study breast cancer .
HY-P10143

MMP-2/MMP-9 Substrate

Peptides Others

MMP-2/MMP-9 Substrate, a synthetic colorimetric substrate, is a peptide .

HY-P2682

MMP-8/MMP-26 Fluorogenic substrate	MMP	Metabolic Disease
MMP-8/MMP-26 Fluorogenic substrate (DNP-Pro-Leu-Ala-Tyr-Trp-Ala-Arg) is a matrix metalloproteinase-8 (MMP-8) fluorogenic substrate. MMP-8/MMP-26 Fluorogenic substrate can be used for the research of atherosclerosis, pulmonary fibrosis, and sepsis .

HY-P2414

MMP-13 Substrate

MMP Inflammation/Immunology

MMP-13 Substrate is a substrate of MMP-13. MMP-13 Substrate can be used for the research of osteoarthritis (OA) .

HY-P10043

MMP-1 Substrate	Peptides	Others
MMP-1 Substrate is a matrix metalloproteinase-1 (MMP-1) selective substrate that can be used for the fluorometric determination of MMP-1 enzymatic activity .

HY-P2689

DNP-PLGMWSR

Peptides Others

DNP-PLGMWSR is a? fluorogenic substrate for MMP-2 and MMP-9 .

HY-P4905

Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2	Peptides	Cancer
Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 is highly selective substrate for matrix metalloproteases 12 (MMP12) substrate with a kcat/Km value of 1.8510 ⁵ M ^-1s ^-1, and poor substrate of other MMPs with the exception of MMP13* (kcat/Km = 0.5310 ⁵ M ^-1s ^-1) and MMP9* (0.33*10 ⁵ M ^-1s ^-1) .

HY-P3474

Mca-Pro-Leu-Gly-Leu-Dap-Ala-Arg-NH2

MMP Cancer

Mca-Pro-Leu-Gly-Leu-Dap-Ala-Arg-NH2 is a fluorescent peptide MMP substrate .
HY-P3474A

Mca-Pro-Leu-Gly-Leu-Dap-Ala-Arg-NH2 TFA

MMP Cancer

Mca-Pro-Leu-Gly-Leu-Dap-Ala-Arg-NH2 (TFA) is a fluorescent peptide MMP substrate .

HY-P4931

Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2	MMP	Cancer
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a fluorescent peptide that is a quenched MMP peptide substrate. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 can be used for real-time quantification of MMP enzymatic activity. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is an elongated peptide of MMP substrate (FS-1) and is active against collagenases (MMP-1, MMP-8, MMP-13 ) and MT1-MMP with higher specificity constants than FS-1 . (Ex/Em=325 nm/400 nm)

HY-P2641

Peptide 74	MMP	Cancer
Peptide 74 is a synthetic peptide containing the prodomain sequence of matrix metalloproteinase (MMP). Peptide 74 inhibits the activated form of the 72-kDa type IV collagenase in vitro .

HY-P3098

Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2	MMP	Others
Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26. Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 can be used to quantify MMP-1, MMP-3 and MMP-26 activity .

HY-P4574

VPLSLYSG

MMP Others

VPLSLYSG is an octapeptide that can be degraded by matrix metalloproteinase-9 (MMP-9), MMP-1 and MMP-2. VPLSLYSG has potential applications in MMP substrates .

HY-P1789

CTTHWGFTLC, CYCLIC	MMP	Inflammation/Immunology Cancer
CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and *MMP-9. The IC₅₀* value for MMP-9 is ~8 μM .

HY-P1789A

CTTHWGFTLC, CYCLIC TFA	MMP	Inflammation/Immunology Cancer
CTTHWGFTLC, CYCLIC TFA is a cyclic peptide inhibitor for matrix metalloproteinases MMP-2 and *MMP-9. The IC₅₀* value for MMP-9 is ~8 μM .

HY-P2213

GPLGIAGQ	MMP Apoptosis	Cancer
GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT) .

HY-P0273

Histatin 5

MMP Inflammation/Immunology

Histatin 5 inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC₅₀s of 0.57 and 0.25 μM, respectively.

HY-P2213A

GPLGIAGQ TFA	MMP Apoptosis	Cancer
GPLGIAGQ TFA, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ TFA can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT) .

HY-P0273A

Histatin 5 TFA

MMP Inflammation/Immunology

Histatin 5 TFA inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC₅₀s of 0.57 and 0.25 μM, respectively.

HY-P3484

Dnp-PLGLWA-DArg-NH2 TFA	MMP	Cancer
Dnp-PLGLWA-DArg-NH2 TFA is a fluorogenic substrate for MMP-1 and MMP-9. Dnp-PLGLWA-DArg-NH2 TFA can be used to quantify the activity of MMPs (Ex=280 nm, Em=360 nm) .

HY-137793

Pro-Leu-Gly-NHOH hydrochloride

MMP Cancer

Pro-Leu-Gly-NHOH hydrochloride is an inhibitor of MMP-8 .

HY-P3513

β-Neo-Endorphin	ERK MMP	Neurological Disease
β-Neo-Endorphin is an endogenous opioid peptide. β-Neo-Endorphin is a hypothalamic “big” Leu-enkephalin of porcine origin. β-Neo-Endorphin shows activation of the Erk1/2, *MMP-2* and *MMP-9* .

HY-P2089

Dnp-PYAYWMR	MMP	Others
Dnp-PYAYWMR is a peptide substrate that selectively targets MMP3. Dnp-PYAYWMR is cleaved by MMP3 to produce Dnp-PYA (nonfluorescent) and YWMR (fluorophore detectable at 360 nm). After incubation of MMP3 with Dnp-PYAYWMR for 2 h, MMP3 fluorescence intensity was measured. Ex/Em=328/350 nm .

HY-P2185

NFF-3	MMP	Others
NFF-3, the peptide, is a selective MMP substrate. NFF-3 selectively binds to *MMP-3* and *MMP-10* to be hydrolyzed. NFF-3 is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .

HY-P5380

TNO211 Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2	MMP	Others
TNO211 is a biological active peptide. (Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.This peptide is a highly soluble fluorogenic MMP substrate for MMP-2, 8, 12, 13 and 14, containing the MMP cleavable Gly-Leu bond and EDANS/DABCYL. Fluorogenic assays using TNO211 are sensitive and can detect MMP activity in culture medium from endothelial cells and untreated synovial fluid from patients. Abs/Em = 340/490 nm.)

HY-P2185A

NFF-3 TFA	MMP	Others
NFF-3 TFA, the peptide, is a selective MMP substrate. NFF-3 TFA selectively binds to *MMP-3* and *MMP-10* to be hydrolyzed. NFF-3 TFA is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 TFA with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .

HY-P6183

LXJ-02	Peptides	Cancer
LXJ-02 is a potent inhibitor of EDPs/EBP peptide–protein interaction, with the K_D of 117 μM for EDPs. LXJ-02 activates the macrophage-MMP-12 axis to increase MMP-12 expression and degrade ECM components like elastin .

HY-P3477

Mca-PLA-Nva-Dap(Dnp)-AR-NH2

Fluorescent Dye Others

Mca-PLA-Nva-Dap(Dnp)-AR-NH2 is a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) .
HY-P3120

Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2

MMP Others

Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14).

HY-P4521

Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt	MMP	Others
Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt is a *MMP12* substrate, and can be used to detect MMP12 enzyme activity .

HY-P4937

NBD-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys-(DMC)-NH2	Peptides	Cancer
NBD-Arg-Pro-Lys-Pro-Leu-Ala-Nva-Trp-Lys-(DMC)-NH2 is an substrate for hydrolysis of the matrix metalloproteinase stromelysin (MMP-3) and can be easily detected at Abs/Em=350/465 nm .

HY-P10359

TAT-QFNP12	TGF-beta/Smad MMP	Neurological Disease
TAT-QFNP12 block the NDRG2-PPM1A binding and reduce Smad2/3 phosphorylation, decreased astrocytic MMP-9 production and BBB disruption after subarachnoid hemorrhage (SAH) .

HY-P2608

DNP-Pro-Leu-Ala-Leu-Trp-Ala-Arg-OH	Fluorescent Dye	Others
DNP-Pro-Leu-Ala-Leu-Trp-Ala-Arg-OH is the substrate for matrix metalloproteinase MMP-1, with a K_m of 26.61 μM. DNP-Pro-Leu-Ala-Leu-Trp-Ala-Arg-OH is utilized as fluorescence probe for detecting protein activity .

HY-W009686F

5-FAM-Pro-Leu-OH

Peptides Others

5-FAM-Pro-Leu-OH is a biological active peptide. (Used as MMP fluorescent reference standard)

HY-P5337

Myristoyl tetrapeptide Ala-Ala-Pro-Val	Peptides	Others
Myristoyl tetrapeptide Ala-Ala-Pro-Val is a biological active peptide. (stimulates the expression of ECM proteins and inhibits the expression of metalloproteinases (MMPs))

HY-P5383

Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2

MMP Others

Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is a biological active peptide. (MMP substrate)

HY-P2036A

FSL-1 TFA 3 Publications Verification	Toll-like Receptor (TLR) MMP HSV Antibiotic	Infection
FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection . FSL-1 TFA induces *MMP-9* production through TLR2 and NF-κB/AP-1 signaling pathways in monocytic THP-1 cells .

HY-P4373

Hepcidin-1 (mouse)	Cathepsin MMP	Metabolic Disease
Hepcidin-1 (mouse) is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) upregulates mRNA levels of TRAP, cathepsin K, and MMP-9 and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) facilitates osteoclast differentiation .

HY-P2716

Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2

MMP Others

Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2 is a biological active peptide. (MMP substrate)

HY-P4373A

Hepcidin-1 (mouse) (TFA)	Cathepsin MMP	Inflammation/Immunology
Hepcidin-1 (mouse) TFA is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) TFA upregulates mRNA levels of TRAP, cathepsin K, and *MMP-9* and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) TFA downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) TFA facilitates osteoclast differentiation .

HY-P2004

FFAGLDD	MMP	Cancer
FFAGLDD is *MMP9* selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release .

HY-P2004A

FFAGLDD TFA	MMP	Cancer
FFAGLDD TFA is *MMP9* selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release .

HY-W011254

Ac-VAD-CHO Ac-Val-Ala-Asp-CHO	Caspase	Cancer
Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) is a pan-caspase inhibitor. Ac-VAD-CHO inhibits dissipation of MMP and cytochrome c release in hypoxia-exposed cells .

HY-118694

TAPI-0	TNF Receptor MMP Bacterial	Infection Cancer
TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC₅₀ of 100 nM. TAPI-0 is a *MMP* inhibitor and also attenuates TNF-α processing .

HY-P10139

Dnp-PLGLWAr-NH2	Peptides	Others
Dnp-PLGLWAr-NH2 is a synthetic collagenase/gelatinase substrate. Dnp-PLGLWAR-NH2 can be used to quantify total MMP activity in APMA-activated conditioned medium samples .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1981

Triolein	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Biological Pesticide Research Agricultural Research	MMP Endogenous Metabolite
Triolein is a symmetric triacylglycerol that reduces upregulation of MMP-1 and has strong antioxidant and anti-inflammatory activities .

HY-N1463

Luteolin 7-O-glucuronide 1 Publications Verification Luteolin 7-glucuronide	Structural Classification Flavonoids other families Classification of Application Fields Flavones Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	MMP
Luteolin 7-O-glucuronide could inhibit Matrix Metalloproteinases *(MMP)* activities, with IC₅₀s of 17.63, 7.99, 11.42, 12.85, 0.03 μM for MMP-1, MMP-3, MMP-8, MMP-9, MMP-13, respectively .

HY-N1454

Apigenin-7-glucuronide 1 Publications Verification Apigenin 7-O-glucuronide	Structural Classification Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	MMP
Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases *(MMP)* activities, with IC₅₀s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.

HY-126956

Porphyra 334	Structural Classification Classification of Application Fields Animals Sunscreen Ketones, Aldehydes, Acids Source classification Metabolic Disease Amino acids Cosmetic Research Disease Research Fields	Reactive Oxygen Species MMP
Porphyra 334 is an antioxidative and anti-photoaging agent. Porphyra 334 suppresses ROS production and the expression of *MMPs* following UVA irradiation .

HY-N10176

D-Isofloridoside	Cardiovascular Disease other families Classification of Application Fields Source classification Plants Disease Research Fields Saccharides	Reactive Oxygen Species MMP
D-Isofloridoside, one of the polysaccharide precursors, has the activity of scavenging free radicals, inhibiting ROS expression, and inhibiting MMP-2 and MMP-9 .

HY-113952

Actinonin 4 Publications Verification (-)-Actinonin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Aminopeptidase Bacterial MMP Apoptosis Antibiotic
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits *MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α* with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities ^[5].

HY-N0431

Astragaloside IV 5+ Cited Publications	Triterpenes Structural Classification Classification of Application Fields Leguminosae Terpenoids Source classification Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Disease Research Fields Cancer	MMP ERK JNK
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.

HY-136699

Excisanin A	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Baccharis densiflora Wedd.	Others
Excisanin A is a potent anticancer agent. Excisanin A inhibits cell proliferation, migration, adhesion and invasion. Excisanin A decreases the expression of MMP-2, MMP-9, p-FAK, p-Src, integrin β1 protein. Excisanin A has the potential for the research of breast cancer .

HY-N0532

Morroniside	Iridoids Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants	MMP Pyroptosis Apoptosis
Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.

HY-N0262

Cordycepin 5+ Cited Publications 3'-Deoxyadenosine	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields Cancer	MMP Bacterial Autophagy Antibiotic
Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced *MMP-1* and *MMP-3* expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner . Cordycepin kills *Mycobacterium tuberculosis* through hijacking the bacterial adenosine kinase .

HY-N7385

Nudol	Orchidaceae Source classification Phenols Polyphenols Plants Epigeneium rotundatum (Lindl.) Summerh.	MMP Apoptosis
Nudol is a phenanthrene compound that has anti-cancer activity. Nudol inhibits cell proliferation, induces cell apoptosis. Nudol inhibits *MMP-2M* and *MMP-9* activity (K_i: 988.9 nM, 1.76 μM, respectively). Nudol can be used in the research of cancers, such as osteosarcoma .

HY-N0069

Solamargine 10+ Cited Publications Solamargin; δ-Solanigrine	Structural Classification Alkaloids Piperidine Alkaloids Solanum Classification of Application Fields Plants Solanaceae Disease Research Fields Saccharides Steroids Cancer	P-glycoprotein Apoptosis
Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. Solamargine significantly inhibits migration and invasion of HepG2 cells by down-regulating MMP-2 and MMP-9 expression and activity .

HY-N5136

25(R,S)-Ruscogenin	Liliaceae Microorganisms Classification of Application Fields Source classification Liriope platyphylla Wang et Tang Plants Disease Research Fields Steroids Cancer	Apoptosis PI3K Akt mTOR
Ruscogenin suppresses HCC metastasis by reducing the expression of MMP-2, MMP-9, uPA, VEGF and HIF-1α via regulating the PI3K/Akt/mTOR signaling pathway . And Ruscogenin alleviates LPS-induced pulmonary endothelial cell apoptosis by su

HY-N0318

Salvianolic acid A 1 Publications Verification	Structural Classification Stilbenes Classification of Application Fields Labiatae Source classification Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	MMP
Salvianolic acid A could protect the blood brain barrier through matrix metallopeptidase 9 (MMP-9) inhibition and anti-inflammation.

HY-N12150

Isozedoarondiol	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Curcuma zanthorrhiza Roxburgh Zingiberaceae	MMP
Isozedoarondiol can be isolated from the rhizomes of Curcuma xanthorrhiza Roxb. Isozedoarondiol inhibits MMP-1 expression in UVB-treated human keratinocytes .

HY-N6862

Lucideric acid A	Triterpenes Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Disease Research Fields Cancer	MMP
Lucideric acid A is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced *MMP-9* activity, with anti-invasive effect on hepatoma cells .

HY-N6860

Lucidenic acid C	Triterpenes Microorganisms Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Disease Research Fields Cancer	MMP
Lucidenic acid C is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced *MMP-9* activity, with anti-invasive effect on hepatoma cells .

HY-N2199

Sotetsuflavone	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Cancer	Apoptosis Autophagy
Sotetsuflavone is a flavonoid that can be isolated from Cycas revolute. Sotetsuflavone inhibits migration and invasion of A549 cells by reversing EMT, and induces cell apoptosis and autophagy. Sotetsuflavone inhibits HIF-1α, VEGF, angiostatin, MMP-9, and MMP-13 expression in A549 cells. Sotetsuflavone also protects mice against Crohn's disease (CD)-like colitis. Sotetsuflavone can be used for research of NSCLC .

HY-N12653

Exserohilone (-)-Exserohilone	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Reactive Oxygen Species
Exserohilone ((-)-Exserohilone) is a thiodiketopiperazine derivative that exhibits the inhibition of TNF-α-induced ROS generation and MMP-1 secretion. Exserohilone increases the procollagen type I α1 secretion in human dermal fibroblasts .

HY-N2117

Isoginkgetin Maximum Cited Publications 12 Publications Verification	Structural Classification Flavonoids Ginkgoaceae Classification of Application Fields Source classification Phenols Polyphenols Plants Biflavones Ginkgo biloba Disease Research Fields Cancer	MMP Akt NF-κB Proteasome Apoptosis Autophagy
Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and *MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis* and activates autophagy .

HY-W745164

3,3′-Bisdemethylpinoresinol	Structural Classification Source classification Lignans Rubiaceae Morinda citrifolia Linn. Phenylpropanoids Plants	MMP
3,3′-Bisdemethylpinoresinol, lignin, is a nature product and has MMP-1 inhibitory activity in UVA-irradiated human dermal fibroblasts. 3,3′-Bisdemethylpinoresinol can be isolated from the seeds of Morinda citrifolia .

HY-77813

Benzyl isothiocyanate	Natural Products Classification of Application Fields Source classification Plants Opiliaceae Disease Research Fields Endocrinology Salvadora persica	Bacterial Apoptosis Antibiotic Parasite
Benzyl isothiocyanate is a member of natural isothiocyanates with antimicrobial activity . Benzyl isothiocyanate potent inhibits cell mobility, migration and invasion nature and matrix metalloproteinase-2 (MMP-2) activity of murine melanoma cells .

HY-118157

3,5,7-Trimethoxyflavone	Structural Classification Flavonoids Flavones Orchidaceae Source classification Plants Nervilia concolor (Blume) Schltr.	Others
3,5,7-Trimethoxyflavone, a flavonoid compound, can inhibit the TNF-α-induced high expression and secretion of MMP-1 by cells. 3,5,7-Trimethoxyflavone can be used to ameliorate skin damage .

HY-121038

Chamazulene	Natural Products Source classification Distemonanthus benthamianus Baill. Plants Compositae	Leukotriene Receptor
Chamazulene, a natural compound, is an antioxidant-type inhibitor of leukotriene B4 formation .

HY-N2388

Auraptene	other families Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Disease Research Fields Cancer	MMP
Auraptene is the most abundant naturally occurring geranyloxycoumarin. Auraptene decreases the secretion of matrix metalloproteinase 2 (MMP-2) as well as key inflammatory mediators, including IL-6, IL-8, and chemokine (C-C motif) ligand-5(CCL5) .

HY-157732

1,2-Dimyristoyl-3-palmitoyl-rac-glycerol	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
1,2-Dimyristoyl-3-palmitoyl-rac-glycerol (MMP) is a triacylglycerol that contains myristic acid and palmitic acid .

HY-N1190

DL-Syringaresinol (±)-Syringaresinol	Structural Classification Source classification Lignans Phenylpropanoids Plants Lauraceae Lindera akoensis Hay.	p38 MAPK AP-1 Bacterial
DL-Syringaresinol ((±)-Syringaresinol), a lignin, inhibits UVA-induced upregulation of MMP-1 by suppressing MAPK/AP-1 signaling in human HaCaT keratinocytes and dermal fibroblasts (HDFs). DL-Syringaresinol has antiphotoaging properties against UVA-induced skin aging. DL-Syringaresinol exhibits weak antimycobacterial activity against Mycobacterium tuberculosis H37Rv .

HY-N12726

Halociline	Structural Classification Microorganisms Marine natural products Source classification Phenols Marine microorganism	p38 MAPK MMP
Halociline, a derivative of alkaloids, that can be isolated from the marine fungus Penicillium griseofulvum. Halociline targets MAPK1, MMP-9, and PIK3CA in gastric cancer cells, potentially mediated by diverse pathways including cancer, lipid metabolism, atherosclerosis, and EGFR tyrosine kinase inhibitor resistance. Halociline possesses antimicrobial, antioxidant and biofilm inhibitory activities .

HY-N12140

2'-epi-2'-O-Acetylthevetin B GHSC-74	Apocynaceae Structural Classification Polysaccharides Source classification Cerbera manghas Linn. Plants Saccharides	Apoptosis
2'-epi-2'-O-Acetylthevetin B (GHSC-74) is a cardiac glycoside that can be isolated from the seeds of Cerbera manghas L. 2'-epi-2'-O-Acetylthevetin B inhibits cell viability, induces apoptosis and loss of mitochondrial membrane potential in HepG2 cells .

HY-N0774

Isofraxidin 1 Publications Verification	Structural Classification Monophenols Classification of Application Fields Source classification Coumarins Phenols Phenylpropanoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Inflammation/Immunology Disease Research Fields Araliaceae	COX MMP Toll-like Receptor (TLR)
Isofraxidin, a coumarin component from Acanthopanax senticosus, inhibits *MMP-7* expression and cell invasion of human hepatoma cells. Isofraxidin inhibits the phosphorylation of ERK1/2 in hepatoma cells . Isofraxidin attenuates the expression of iNOS and COX-2, Isofraxidinalso inhibits TLR4/myeloid differentiation protein-2 (MD-2) complex formation .

HY-N2205

Esculentoside H	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Phytolacca acinosa Roxb. Plants Disease Research Fields Phytolaccaceae Cancer	NF-κB JNK
Esculentoside H (EsH) is a saponin isolated from the root extract of perennial plant Phytolacca esculenta . Esculentoside H (EH) has anti-tumor activity, the mechanism is related to the capacity for TNFrelease . Esculentoside H (EsH) suppresses colon cancer cell migration through blockage of the JNK1/2 and NF-κB signaling-mediated matrix metalloproteinases-9 (MMP-9) expression .

HY-N0084

Betulinaldehyde 4 Publications Verification Betulinic aldehyde; Betunal	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	Bacterial
Betulinaldehyde (Betunal) Has anti-cancer and anti-staphylococcus aureus activity. Betulinaldehyde Suppressible Akt, MAPK sum STAT3 Signal path, increase self-transfer, Suppression A549 Cellular vitality, increase and transfer. Betulinaldehyde suppresses PLCγ1/Ca ²⁺/MMP9 signal pathway, has a key effect on vascular plasticity, and is available for cardiovascular disease (CVD) research.

HY-B2162

Chondroitin sulfate 4 Publications Verification Chondroitin polysulfate	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Saccharides	NO Synthase MMP Endogenous Metabolite
Chondroitin sulfate, one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis. Chondroitin sulfate reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS and *MMPs*.

HY-N2497

Isoliquiritin apioside 1 Publications Verification	Flavonoids Chalcones other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	NF-κB MMP p38 MAPK
Isoliquiritin apioside significantly decreases PMA-induced increases in *MMP9* activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells .

HY-N4028

Hydrangenol	Structural Classification Classification of Application Fields Anti-aging Source classification Hydrangeaceae Coumarins Phenylpropanoids Cosmetic Research Plants Inflammation/Immunology Disease Research Fields	MMP COX Interleukin Related p38 MAPK ERK Keap1-Nrf2
Hydrangenol is an orally active antiphotoaging compound. It can be isolated from Hydrangea serrata leaves. Hydrangenol prevents wrinkle formation by reducing *MMP* and inflammatory cytokine expression and increasing moisturizing factors and antioxidant genes level .

HY-N1940

β-Anhydroicaritin 1 Publications Verification	Flavonols Structural Classification Flavonoids Classification of Application Fields Plants Burseraceae Inflammation/Immunology Disease Research Fields Boswellia carterii	Interleukin Related TNF Receptor MMP
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties . β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats . β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca ²⁺, and markedly decreases iNOS protein expression .

HY-B2162A

Chondroitin sulfate sodium (from shark cartilage) 4 Publications Verification Chondroitin polysulfate sodium (from shark cartilage)	Structural Classification Polysaccharides Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Saccharides	NO Synthase MMP Endogenous Metabolite
Chondroitin sulfate sodium (from shark cartilage), one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis. Chondroitin sulfate reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS and MMPs .

HY-N3387

Licoricidin	Natural Products Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Glycyrrhiza uralensis Fisch.	Apoptosis NF-κB Akt MMP
Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin (LCD) inhibit SW480 cells (IC₅₀=7.2 μM) by inducing cycle arrest, apoptosis and autophagy, and is a potential chemopreventive or chemotherapeutic agent against colorectal cancer . Licoricidin (LCD) inhibits Lung Metastasis by inhibition of tumor angiogenesis and lymphangiogenesis as well as changes in the local microenvironment of tumor tissues the anticarcinogenic effect . Licoricidin enhanced gemcitabine-induced cytotoxicity in Osteosarcoma (OS) cells by inactivation of the Akt and NF-κB pathways in vitro and in vivo . Licoricidin blocks UVA-induced photoaging via ROS scavenging, limits the activity of *MMP-1*, it can be considered as an active ingredient in new topically applied anti-ageing formulations .

HY-N2350

Cynaropicrin	Saussurea costus (Falc.) Lipsch. Classification of Application Fields Source classification Phenols Plants Compositae Disease Research Fields Cancer	MMP NF-κB TNF Receptor
Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC₅₀s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.

HY-107855

DL-Mevalonolactone 1 Publications Verification (±)-Mevalonolactone; Mevalolactone	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone is orally active against HMGCR mutation and statin caused myopathy . DL-Mevalonolactone induces inflammation and oxidative stress response with decreased mitochondrial membrane potential (MMP) and induces mitochondrial swelling ^[2][4].

HY-N6013

Aloin(mixture of A&B)	Infection Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Aloe vera (L.) Burm. f. Plants Inflammation/Immunology Disease Research Fields	MMP Bacterial Fungal
Aloin (mixture of A&B) is anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) has diverse biological activities such as anti-inflammatory, immunity, antidiabetic, antioxidant, antibacterial, antifungal, and antitumor activities. Aloin (mixture of A&B) also an effective inhibitor of stimulated granulocyte matrix metalloproteinases *(MMPs)* .

HY-N0801

Polygalacic acid	Triterpenes Terpenoids Source classification Polygalaceae Plants Polygala tenuifolia Willd.	MMP Cholinesterase (ChE)
Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits *MMP* expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment . Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex .

HY-134000

Emodic acid NSC624610	Quinones Structural Classification Human Gut Microbiota Metabolites Microorganisms Leguminosae Cercis chinensis Bunge Anthraquinones Source classification Plants Endogenous metabolite	p38 MAPK NF-κB ERK JNK VEGFR MMP
Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and *MMP*, thereby inhibiting the invasion and migration potential of cancer cells .

HY-N1401

20(R)-Ginsenoside Rh2 1 Publications Verification	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Source classification Plants Endogenous metabolite Infection Human Gut Microbiota Metabolites Terpenoids Inflammation/Immunology Disease Research Fields Araliaceae	MMP Apoptosis HSV
20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as a cell antiproliferator. It has anticancer effects via blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis, and has anti-inflammatory and antioxidative activity . 20(R)-Ginsenoside Rh2 inhibits the replication and proliferation of mouse and human gammaherpesvirus 68 (MHV-68) with an IC₅₀ of 2.77 μM for murine MHV-68 .

HY-N2503

Ginsenoside F4	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae	Apoptosis MMP
Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis . Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues .

HY-N5072

Desmethylglycitein 4',6,7-Trihydroxyisoflavone	Flavonoids Classification of Application Fields Leguminosae Glycine max (L.) merr Source classification Phenols Polyphenols Plants Disease Research Fields Isoflavones Cancer	CDK PI3K PKC
Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity . Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1) . Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes .

Species:	Human (24) Mouse (8) Rat (3) Cynomolgus (2)
Tag:	SUMO (1) His (27) Tag Free (10) Avi (2)
Source:	HEK293 (24) CHO (1) P. pastoris (4) E. coli (8)

Cat. No.	Compare	Product Name	Species	Source

HY-P75929

	MMP-19 Protein, Human Matrix metalloproteinase-19; mmp-19; mmp-18; RASI	Human	E. coli
	MMP-19 proteins act as endopeptidases that degrade multiple components of the extracellular matrix, including aggrecan and cartilage oligomeric matrix protein (comp), during critical developmental processes, hemostasis, and pathological conditions such as arthritis. ) plays a key role. In addition to participating in matrix remodeling, MMP-19 may also contribute to neovascularization, or angiogenesis. MMP-19 Protein, Human is the recombinant human-derived MMP-19 protein, expressed by E. coli , with tag free. The total length of MMP-19 Protein, Human is 156 a.a., with molecular weight of ~18 kDa.

HY-P700007

	MMP-14 Protein, Human (His-SUMO) Matrix metalloproteinase 14 ; Matrix metalloproteinase-14; Membrane type 1 matrix metalloproteinase ; Membrane type 1 metalloprotease; Membrane type matrix metalloproteinase 1; Membrane-type-1 matrix metalloproteinase; mmp 14; mmp X1; mmp-14; mmp-X1; mmp14; mmp14_HUMAN; mmpX1; MT mmp 1	Human	E. coli
	MMP-14 protein is an endopeptidase that degrades collagen and activates progelatinase A. MMP-14 Protein, Human (His-SUMO) is the recombinant human-derived MMP-14 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of MMP-14 Protein, Human (His-SUMO) is 471 a.a., with molecular weight of ~69.9 KDa.

HY-P79097

	MMP-16 Protein, Human (I152N, His) Matrix metalloproteinase-16; mmp16; mmp-16; mmp-X2; Membrane-type matrix metalloproteinase 3; MT-mmp 3; MTmmp3; Membrane-type-3 matrix metalloproteinase; MT3-mmp; MT3mmp; C8orf57; mmpX2; Matrix Metalloproteinase 16/Membrane Type 3 mmp	Human	E. coli
	The MMP-16 protein functions as an endopeptidase capable of degrading various components of the extracellular matrix, particularly type III collagen and fibronectin. Its effects extend to the activation of progelatinase A, which contributes to the dynamic remodeling of the extracellular matrix within blood vessels. MMP-16 Protein, Human (I152N, His) is the recombinant human-derived MMP-16 protein, expressed by E. coli , with C-10*His labeled tag. The total length of MMP-16 Protein, Human (I152N, His) is 260 a.a., with molecular weight of ~29 kDa.

HY-P701987

	MMP-13 Protein, Human (His) mmp13; Collagenase 3; Matrix metalloproteinase-13; mmp-13	Human	E. coli
	The MMP-13 protein plays a role in the degradation of extracellular matrix proteins, especially fibrillar collagen, fibronectin, TNC, and ACAN. It cleaves triple-helical collagen, preferentially cleaves type II collagen, and can also target other collagen types. MMP-13 Protein, Human (His) is the recombinant human-derived MMP-13 protein, expressed by E. coli , with N-6*His labeled tag. The total length of MMP-13 Protein, Human (His) is 172 a.a., .

HY-P70250

	MMP-1 Protein, Human (HEK293, His) rHuInterstitial collagenase/mmp-1, His; Interstitial Collagenase; Fibroblast Collagenase; Matrix Metalloproteinase-1; mmp-1; mmp1; CLG	Human	HEK293
	The MMP-1 protein acts as an enzyme capable of cleaving types I, II, and III collagen at specific sites within the helical domain. In addition, it exhibits lytic activity against type VII and type X collagen. MMP-1 Protein, Human (HEK293, His) is the recombinant human-derived MMP-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of MMP-1 Protein, Human (HEK293, His) is 450 a.a., with molecular weight of 49-61 kDa.

HY-P70342

	MMP-12 Protein, Mouse (HEK293, His) rMuMacrophage metalloelastase/mmp12, His; Macrophage metalloelastase; MME; Matrix metalloproteinase-12; mmp-12; mmp12; Mme; Mmel	Mouse	HEK293
	MMP-12 protein has significant elastolytic activity and may contribute to tissue damage and remodeling. Its substrate preferences include preference for leucine at the P1' site and aromatic/hydrophobic residues at the P1 site, and preference for small hydrophobic residues such as alanine at the P3 site. MMP-12 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MMP-12 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of MMP-12 Protein, Mouse (HEK293, His) is 445 a.a., with molecular weight of ~64.0 kDa.

HY-P74744

	MMP-12 Protein, Human Macrophage metalloelastase; MME; mmp-12; HME	Human	E. coli
	MMP-12 protein is potentially engaged in tissue injury and remodeling, displaying significant elastolytic activity. It shows flexibility at the P1' site, accommodating both large and small amino acids, yet favoring leucine. At the P1 site, it prefers aromatic or hydrophobic residues, with a tendency for small hydrophobic residues like alanine in the P3 position. MMP-12 Protein, Human is the recombinant human-derived MMP-12 protein, expressed by E. coli , with tag free. The total length of MMP-12 Protein, Human is 163 a.a., with molecular weight of ~18 kDa.

HY-P70250A

MMP-1 Protein, Human (HEK293, C-His)

rHuInterstitial collagenase/mmp-1, His; Interstitial Collagenase; Fibroblast Collagenase; Matrix Metalloproteinase-1; mmp-1; mmp1; CLG
Human HEK293

HY-P76498

	MMP-26 Protein, Human Matrix metalloproteinase-26; mmp-26; Endometase; Matrilysin-2	Human	E. coli
	The MMP-26 protein has broad substrate specificity and hydrolyzes type IV collagen, fibronectin, fibrinogen, β-casein, type I gelatin, and α-1 protease inhibitors. The versatility of this enzyme suggests involvement in the degradation and remodeling of various extracellular matrix components. MMP-26 Protein, Human is the recombinant human-derived MMP-26 protein, expressed by E. coli , with tag free. The total length of MMP-26 Protein, Human is 172 a.a., with molecular weight of ~19 KDa.

HY-P70139

	*Stromelysin-1/MMP-3 Protein, Human (HEK293, His)* rHuStromelysin-1/mmp-3, His; Stromelysin-1; SL-1; Matrix metalloproteinase-3; mmp-3; Transin-1; mmp3; STMY1	Human	HEK293
	The Stromelysin-1/MMP-3 protein is a multifunctional metalloprotease that degrades a variety of extracellular matrix components and activates molecules such as growth factors, plasminogen, and MMP9. It is released into the ECM and is activated through the plasmin cascade. Stromelysin-1/MMP-3 Protein, Human (HEK293, His) is the recombinant human-derived Stromelysin-1/MMP-3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Stromelysin-1/MMP-3 Protein, Human (HEK293, His) is 460 a.a., with molecular weight of ~60 kDa.

HY-P72507

	MMP-8 Protein, Human (HEK293, His) Neutrophil collagenase; Matrix metalloproteinase-8; mmp-8; PMNL collagenase; PMNL-CL; mmp8; CLG1	Human	HEK293
	MMP-8, also known as matrix metalloproteinase-8 or collagenase-2, is recognized for its enzymatic abilities, particularly its ability to break down fibrillar types I, II, and III collagen. This enzymatic activity suggests that MMP-8 plays an important role in the remodeling and turnover of collagen-rich tissues such as connective tissue, cartilage, and bone. MMP-8 Protein, Human (HEK293, His) is the recombinant human-derived MMP-8 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of MMP-8 Protein, Human (HEK293, His) is 447 a.a., with molecular weight of approximately 64.09 kDa.

HY-P78328

	MMP-8 Protein, Mouse (HEK293, His) mmp-8; PMNL-CL; CLG1; mmp8; Collagenase 2; PMNL-CL; HNC	Mouse	HEK293
	MMP-8 protein degrades different fibrillar collagens, such as type I, II, and III. It is implicated in the breakdown of collagen fibers during uterine involution. MMP-8 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MMP-8 protein, expressed by HEK293 , with C-His labeled tag. The total length of MMP-8 Protein, Mouse (HEK293, His) is 445 a.a., with molecular weight of 65-70 kDa.

HY-P73298

	MMP-8 Protein, Human (HEK293) Neutrophil collagenase; mmp-8; PMNL-CL; CLG1	Human	HEK293
	MMP-8, also known as matrix metalloproteinase-8 or collagenase-2, is recognized for its enzymatic abilities, particularly its ability to break down fibrillar types I, II, and III collagen. This enzymatic activity suggests that MMP-8 plays an important role in the remodeling and turnover of collagen-rich tissues such as connective tissue, cartilage, and bone. MMP-8 Protein, Human (HEK293) is the recombinant human-derived MMP-8 protein, expressed by HEK293 , with N-Met labeled tag. The total length of MMP-8 Protein, Human (HEK293) is 447 a.a., with molecular weight of ~65 kDa.

HY-P73808

	MMP-8 Protein, Mouse (HEK293) Neutrophil collagenase; mmp-8; PMNL-CL; CLG1	Mouse	HEK293
	MMP-8 protein degrades different fibrillar collagens, such as type I, II, and III. It is implicated in the breakdown of collagen fibers during uterine involution. MMP-8 Protein, Mouse (HEK293) is the recombinant mouse-derived MMP-8 protein, expressed by HEK293, with tag free. The total length of MMP-8 Protein, Mouse (HEK293) is 445 a.a., with molecular weight of ~65 kDa.

HY-P73809

	MMP-8 Protein, Mouse (CHO, His) Neutrophil collagenase; mmp-8; PMNL-CL; CLG1	Mouse	CHO
	MMP-8 protein degrades different fibrillar collagens, such as type I, II, and III. It is implicated in the breakdown of collagen fibers during uterine involution. MMP-8 Protein, Mouse (CHO, His) is the recombinant mouse-derived MMP-8 protein, expressed by CHO, with C-His labeled tag. The total length of MMP-8 Protein, Mouse (CHO, His) is 465 a.a., with molecular weight of ~57 kDa.

HY-P73297

	*Stromelysin-1/MMP-3 Protein, Human* Stromelysin-1; SL-1; mmp-3; Transin-1; STMY1	Human	E. coli
	The Stromelysin-1/MMP-3 protein is a multifunctional metalloprotease that degrades a variety of extracellular matrix components and activates molecules such as growth factors, plasminogen, and MMP9. It is released into the ECM and is activated through the plasmin cascade. Stromelysin-1/MMP-3 Protein, Human is the recombinant human-derived Stromelysin-1/MMP-3 protein, expressed by E. coli , with tag free. The total length of Stromelysin-1/MMP-3 Protein, Human is 255 a.a., with molecular weight of ~34 kDa.

HY-P70268

	MMP-2 Protein, Human (HEK293, His) 2 Publications Verification rHu72 kDa type IV collagenase/mmp-2, His ; 72 kDa Type IV Collagenase; 72 kDa Gelatinase; Gelatinase A; Matrix Metalloproteinase-2; mmp-2; TBE-1; mmp2; CLG4A	Human	HEK293
	MMP-2 protein is a multifunctional metalloproteinase that actively participates in physiological processes such as vascular remodeling, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. In addition to degrading extracellular matrix proteins, it also acts on non-matrix proteins to promote vasoconstriction. MMP-2 Protein, Human (HEK293, His) is the recombinant human-derived MMP-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of MMP-2 Protein, Human (HEK293, His) is 631 a.a., with molecular weight of 68-78 kDa.

HY-P700139AF

	*Animal-Free MMP-2 Protein, Human (His)* rHu72 kDa type IV collagenase/mmp-2, His ; 72 kDa Type IV Collagenase; 72 kDa Gelatinase; Gelatinase A; Matrix Metalloproteinase-2; mmp-2; TBE-1; mmp2; CLG4A	Human	E. coli
	MMP-2 protein is a multifunctional metalloproteinase that actively participates in physiological processes such as vascular remodeling, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. In addition to degrading extracellular matrix proteins, it also acts on non-matrix proteins to promote vasoconstriction. Animal-Free MMP-2 Protein, Human (His) is the recombinant human-derived animal-FreeMMP-2 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free MMP-2 Protein, Human (His) is 551 a.a., with molecular weight of ~63.00 kDa.

HY-P700573

	MMP-2 Protein, Rat (P. pastoris, His) rHu72 kDa type IV collagenase/mmp-2, His ; 72 kDa Type IV Collagenase; 72 kDa Gelatinase; Gelatinase A; Matrix Metalloproteinase-2; mmp-2; TBE-1; mmp2; CLG4A	Rat	P. pastoris
	MMP-2 is a multifunctional metalloproteinase that plays multiple roles in vasculature remodeling, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. In addition to degrading extracellular matrix proteins, MMP-2 also acts on non-matrix proteins to promote vasoconstriction. MMP-2 Protein, Rat (P. pastoris, His) is the recombinant rat-derived MMP-2 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of MMP-2 Protein, Rat (P. pastoris, His) is 553 a.a., with molecular weight of 64.1 kDa.

HY-P73300

	MMP-9 Protein, Human (HEK293) Matrix metalloproteinase-9; mmp-9; Gelatinase B; GELB; CLG4B	Human	HEK293
	MMP-9 is an important member of the MMP protein family and regulates the extracellular matrix during physiological processes such as development and tissue remodeling. It involves arthritis and metastasis. MMP-9 Protein, Human (HEK293) is the recombinant human-derived MMP-9 protein, expressed by HEK293 , with tag free. The total length of MMP-9 Protein, Human (HEK293) is 688 a.a., with molecular weight of 80-95 kDa.

HY-P73807

	MMP-9 Protein, Mouse (HEK293) Matrix metalloproteinase-9; mmp-9; Gelatinase B; GELB; CLG4B	Mouse	HEK293
	The MMP-9 protein is a matrix metalloproteinase that is critical for local extracellular matrix proteolysis and leukocyte migration. It is suggested that it may be involved in bone osteoclastic resorption. MMP-9 Protein, Mouse (HEK293) is the recombinant mouse-derived MMP-9 protein, expressed by HEK293 , with tag free. The total length of MMP-9 Protein, Mouse (HEK293) is 710 a.a., with molecular weight of ~100 kDa.

HY-P700893

	MMP-9 Protein, Cynomolgus (HEK293, His) mmp-9; GELB; CLG4B; MANDP2; Gelatinase B	Cynomolgus	HEK293
	The MMP-9 protein is a matrix metalloproteinase that is critical for local extracellular matrix proteolysis and leukocyte migration. It is suggested that it may be involved in bone osteoclastic resorption. MMP-9 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived MMP-9 protein, expressed by HEK293 , with C-His labeled tag. The total length of MMP-9 Protein, Cynomolgus (HEK293, His) is 687 a.a., with molecular weight of 85-100 kDa.

HY-P70145

	MMP-9 Protein, Human (HEK293, His) rHuMatrix metalloproteinase-9/mmp-9, His; Matrix metalloproteinase-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; mmp9	Human	HEK293
	The MMP-9 protein is a matrix metalloproteinase that is critical for local extracellular matrix proteolysis and leukocyte migration. It is suggested that it may be involved in bone osteoclastic resorption. MMP-9 Protein, Human (HEK293, His) is the recombinant human-derived MMP-9 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of MMP-9 Protein, Human (HEK293, His) is 689 a.a., with molecular weight of ~90.0 kDa.

HY-P70351

	MMP-9 Protein, Mouse (HEK293, His) rMuMatrix metalloproteinase-9/mmp-9, His; Matrix metalloproteinase-9; mmp-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; GELB	Mouse	HEK293
	The MMP-9 protein is a matrix metalloproteinase that is critical for local extracellular matrix proteolysis and leukocyte migration. It is suggested that it may be involved in bone osteoclastic resorption. MMP-9 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MMP-9 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of MMP-9 Protein, Mouse (HEK293, His) is 711 a.a., with molecular weight of ~100.0 kDa.

HY-P70145A

	MMP-9 Protein, Human (HEK293, C-His) rHuMatrix metalloproteinase-9/mmp-9, His; Matrix metalloproteinase-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; mmp9	Human	HEK293
	MMP-9 Protein, a matrix metalloproteinase, plays a crucial role in localized extracellular matrix breakdown, facilitating leukocyte migration. Its potential involvement in bone osteoclastic resorption is suggested. MMP-9 cleaves KiSS1 and NINJ1, generating their secreted forms. It degrades type IV and type V collagen, producing distinct fragments, and fibronectin, while laminin and Pz-peptide remain unaffected. MMP-9 Protein, Human (HEK293, C-His) is the recombinant human-derived MMP-9 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of MMP-9 Protein, Human (HEK293, C-His) is 689 a.a., with molecular weight of ~82.5 kDa.

HY-P73301

	MMP-9 Protein, Rat (HEK293, His) Matrix metalloproteinase-9; mmp-9; Gelatinase B; GELB; CLG4B	Rat	HEK293
	Matrix metalloproteinase-9 (Mmp9) is a member of the matrix metalloproteinase (MMP) family. Mmp9 is secreted as inactive proproteins which are activated when cleaved by extracellular proteinases to generate a mature, zinc-dependent endopeptidase enzyme that degrades collagens of type IV, V and XI, and elastin. Mmp9 is also involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow. MMP-9 Protein, Rat (HEK293, His) is the recombinant rat-derived MMP-9 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of MMP-9 Protein, Rat (HEK293, His) is 689 a.a., with molecular weight of approximately 95 kDa.

HY-P78492

	MMP-9 Protein, Human (HEK293, His-Avi) mmp-9; GELB; CLG4B; MANDP2; Gelatinase B	Human	HEK293
	MMP-9 Protein, a matrix metalloproteinase, plays a crucial role in localized extracellular matrix breakdown, facilitating leukocyte migration. Its potential involvement in bone osteoclastic resorption is suggested. MMP-9 cleaves KiSS1 and NINJ1, generating their secreted forms. It degrades type IV and type V collagen, producing distinct fragments, and fibronectin, while laminin and Pz-peptide remain unaffected. MMP-9 Protein, Human (HEK293, His-Avi) is the recombinant human-derived MMP-9 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of MMP-9 Protein, Human (HEK293, His-Avi) is 688 a.a., with molecular weight of 85-100 kDa.

HY-P70351A

	MMP-9 Protein, Mouse (HEK293, C-His) rMuMatrix metalloproteinase-9/mmp-9, His; Matrix metalloproteinase-9; mmp-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; GELB	Mouse	HEK293
	The MMP-9 protein is a matrix metalloproteinase that is critical for local extracellular matrix proteolysis and leukocyte migration. It is suggested that it may be involved in bone osteoclastic resorption. MMP-9 Protein, Mouse (HEK293, C-His) is the recombinant mouse-derived MMP-9 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of MMP-9 Protein, Mouse (HEK293, C-His) is 711 a.a., with molecular weight of ~93.64 kDa.

HY-P78175

	MMP-9 Protein, Human (Biotinylated, HEK293, His-Avi) mmp-9; GELB; CLG4B; MANDP2; Gelatinase B	Human	HEK293
	MMP-9 Protein, a matrix metalloproteinase, plays a crucial role in localized extracellular matrix breakdown, facilitating leukocyte migration. Its potential involvement in bone osteoclastic resorption is suggested. MMP-9 cleaves KiSS1 and NINJ1, generating their secreted forms. It degrades type IV and type V collagen, producing distinct fragments, and fibronectin, while laminin and Pz-peptide remain unaffected. MMP-9 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived MMP-9 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of MMP-9 Protein, Human (Biotinylated, HEK293, His-Avi) is 688 a.a., with molecular weight of 95-105 kDa.

HY-P700572

	MMP-9 Protein, Human (601a.a, P. pastoris, His) rHuMatrix metalloproteinase-9/mmp-9, His; Matrix metalloproteinase-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; mmp9	Human	P. pastoris
	MMP-9 Protein, a matrix metalloproteinase, plays a crucial role in localized extracellular matrix breakdown, facilitating leukocyte migration. Its potential involvement in bone osteoclastic resorption is suggested. MMP-9 cleaves KiSS1 and NINJ1, generating their secreted forms. It degrades type IV and type V collagen, producing distinct fragments, and fibronectin, while laminin and Pz-peptide remain unaffected. MMP-9 Protein, Human (601a.a, P. pastoris, His) is the recombinant human-derived MMP-9 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of MMP-9 Protein, Human (601a.a, P. pastoris, His) is 601 a.a., with molecular weight of 68.6 kDa.

HY-P73296

	MMP-2 Protein, Human (HEK293) 3 Publications Verification 72 kDa Type IV Collagenase; Gelatinase A; mmp-2; TBE-1; CLG4A	Human	HEK293
	MMP-2 protein is a multifunctional metalloproteinase that actively participates in physiological processes such as vascular remodeling, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. In addition to degrading extracellular matrix proteins, it also acts on non-matrix proteins to promote vasoconstriction. MMP-2 Protein, Human (HEK293) is the recombinant human-derived MMP-2 protein, expressed by HEK293 , with tag free. The total length of MMP-2 Protein, Human (HEK293) is 631 a.a., with molecular weight of ~72 kDa.

HY-P73810

	MMP-2 Protein, Mouse (HEK293, His) 72 kDa Type IV Collagenase; Gelatinase A; mmp-2; TBE-1; CLG4A	Mouse	HEK293
	MMP-2 protein is a ubiquitous metalloprotease that contributes to vasculature remodeling, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. In addition to extracellular matrix degradation, it also targets non-matrix proteins and promotes vasoconstriction. MMP-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MMP-2 protein, expressed by HEK293 , with N-His labeled tag. The total length of MMP-2 Protein, Mouse (HEK293, His) is 254 a.a., with molecular weight of ~34.54 kDa.

HY-P700793

	MMP-8 Protein, Cynomolgus (447a.a, HEK293, His) PMNL-CL; CLG1; mmp8; Collagenase 2; PMNL-CL; HNC	Cynomolgus	HEK293
	MMP-8, also known as matrix metalloproteinase-8 or collagenase-2, is recognized for its enzymatic abilities, particularly its ability to break down fibrillar types I, II, and III collagen. This enzymatic activity suggests that MMP-8 plays an important role in the remodeling and turnover of collagen-rich tissues such as connective tissue, cartilage, and bone. MMP-8 Protein, Cynomolgus (447a.a, HEK293, His) is the recombinant cynomolgus-derived MMP-8 protein, expressed by HEK293 , with C-His labeled tag. The total length of MMP-8 Protein, Cynomolgus (447a.a, HEK293, His) is 447 a.a., with molecular weight of 60-70 kDa.

HY-P700571

	MMP-10 Protein, Human (P. pastoris, His) EC 3.4.24; EC 3.4.24.22; matrix metallopeptidase 10 (stromelysin 2); matrix metalloprotease 10; matrix metalloproteinase 10 (stromelysin 2); Matrix metalloproteinase-10; mmp10; mmp-10; SL-2; STMY2stromelysin-2; Stromelysin 2; transin 2; transin-2	Human	P. pastoris
	MMP-10 protein is a member of the matrix metalloproteinase family and plays a crucial role in extracellular matrix remodeling by promoting the degradation of various substrates. As a protease, MMP-10 is involved in tissue homeostasis, wound healing, and inflammatory responses. MMP-10 Protein, Human (P. pastoris, His) is the recombinant human-derived MMP-10 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of MMP-10 Protein, Human (P. pastoris, His) is 378 a.a., with molecular weight of 45 kDa.

HY-P700574

	MMP-7 Protein, Rat (P. pastoris, His) Matrilysin; Matrin; Matrix metalloproteinase-7; Pump-1 protease; MPSL1; PUMP1	Rat	P. pastoris
	The MMP-7 protein is an enzyme with multifunctional substrate-degrading capabilities, acting on casein, gelatin (types I, III, IV, and V) and fibronectin. As a multifunctional matrix metalloproteinase, MMP-7 contributes to tissue remodeling and renewal, including procollagenase activation, demonstrating its role in the regulation of collagen metabolism. MMP-7 Protein, Rat (P. pastoris, His) is the recombinant rat-derived MMP-7 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of MMP-7 Protein, Rat (P. pastoris, His) is 170 a.a., with molecular weight of 20.9 kDa.

HY-P702527

	MMP-13 Protein, Human (HEK293) CLG 3; CLG3EC 3.4.24; collagenase 3; EC 3.4.24.-; EC 3.4.24.22; EC 3.4.24.24; EC 3.4.24.35; EC 3.4.24.65; EC 3.4.24.7; MANDP1; matrix metallopeptidase 13 (collagenase 3); matrix metalloproteinase 13 (collagenase 3); Matrix metalloproteinase-13; mmp13; mmp-13	Human	HEK293
	The MMP-13 protein plays a role in the degradation of extracellular matrix proteins, especially fibrillar collagen, fibronectin, TNC, and ACAN. It cleaves triple-helical collagen, preferentially cleaves type II collagen, and can also target other collagen types. MMP-13 Protein, Human (HEK293) is the recombinant human-derived MMP-13 protein, expressed by HEK293 , with tag free.

HY-P71156

	Lipocalin-2/NGAL Protein, Human (HEK293, His) Neutrophil gelatinase-associated lipocalin; NGAL; 25 kDa alpha-2-microglobulin-related subunit of mmp-9; Lipocalin-2; Oncogene 24p3; Siderocalin LCN2; p25; HNL; NGAL	Human	HEK293
	Lipocalin-2/NGAL is an iron transporter that plays a crucial role in various cellular processes. It interacts with the siderophore 2,3-DHBA to transport iron into or out of cells depending on cellular needs. Lipocalin-2/NGAL Protein, Human (HEK293, His) is the recombinant human-derived Lipocalin-2/NGAL protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Lipocalin-2/NGAL Protein, Human (HEK293, His) is 178 a.a., with molecular weight of ~21-24 kDa.

Cat. No.	Product Name	Chemical Structure

HY-N1981S1

Triolein-d5
Triolein-d₅ is the deuterium labeled Triolein. Triolein is a symmetrical triacylglycerol, reduces MMP-1 upregulation, with strong antioxidant and anti-inflammatory properties[1].

HY-N1981S

Triolein-13C3
Triolein- ¹³C₃ is the ¹³C-labeled Triolein. Triolein is a symmetrical triacylglycerol, reduces MMP-1 upregulation, with strong antioxidant and anti-inflammatory properties[1].

HY-B0099S

Edaravone-d5
Edaravone-d₅ is a deuterium labeled Edaravone. Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator[1][2][3][4].

HY-77813S

Benzyl isothiocyanate-d7
Benzyl isothiocyanate-d₇ is the deuterium labeled Benzyl isothiocyanate. Benzyl isothiocyanate is a member of natural isothiocyanates with antimicrobial activity[1][2]. Benzyl isothiocyanate potent inhibits cell mobility, migration and invasion nature and matrix metalloproteinase-2 (MMP-2) activity of murine melanoma cells[2].

HY-13571AS1

Beclometasone dipropionate-d10
Beclometasone dipropionate-d₁₀ is the deuterium labeled Beclometasone dipropionate. Betamethasone dipropionate, the proagent of Betamethasone, is an orally active and potent glucocorticoid with anti-inflammatory and immunosuppressive activity. Betamethasone appears to be an effective inhibitor of LPS-induced inflammation and MMP release[1][2].

HY-13571AS

Beclometasone dipropionate-d6
Beclometasone dipropionate-d₆ is deuterium labeled Beclometasone dipropionate. Betamethasone dipropionate, the proagent of Betamethasone, is an orally active and potent glucocorticoid with anti-inflammatory and immunosuppressive activity. Betamethasone appears to be an effective inhibitor of LPS-induced inflammation and MMP release[1][2].

HY-W004544S

o-Phenanthroline-d8
o-Phenanthroline-d₈ is the deuterium labeled o-Phenanthroline. o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a MMP inhibitor[1][2].

Cat. No.	Product Name	Application	Reactivity

HY-P80754

MMP1 Antibody mmp1; CLG; Interstitial collagenase; Fibroblast collagenase; Matrix metalloproteinase-1; mmp-1	WB, IP	Human
MMP1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 54 kDa, targeting to MMP1. It can be used for WB,IP assays with tag free, in the background of Human.

HY-P81845

MMP14 Antibody (YA1590)

mmp-14; mmp-X1; MT-mmp; MT1mmp; MTmmp1; WNCHRS; MT1-mmp; MT-mmp 1
WB, IHC-P, IP Human, Hamster

HY-P81983

MMP17 Antibody (YA1728) mmp17; MT4mmp; Matrix metalloproteinase-17; mmp-17; Membrane-type matrix metalloproteinase 4; MT-mmp 4; MTmmp4; Membrane-type-4 matrix metalloproteinase; MT4-mmp; MT4mmp	WB, IHC-P, ICC/IF	Human, Mouse, Rat

HY-P83398

MMP13 Antibody (YA3143)

mmp13; Collagenase 3; Matrix metalloproteinase-13; mmp-13
WB Human, Mouse

HY-P80754A

MMP1 Antibody(YA3394) mmp1; CLG; Interstitial collagenase; Fibroblast collagenase; Matrix metalloproteinase-1; mmp-1	WB, FC, ICC/IF, IHC-P	Human
MMP1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 54 kDa, targeting to MMP1. It can be used for WB,FC,ICC/IF,IHC-P assays with tag free, in the background of Human.

HY-P80424

MMP3 Antibody	WB, IHC-P	Human, Mouse, Rat
MMP3 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 54 kDa, targeting to MMP3. It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P80509

MMP2 Antibody	WB, IHC-P	Human, Mouse
MMP2 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 72 kDa, targeting to MMP2. It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse.

HY-P81117

MMP7 Antibody Matrilysin; Matrilysin uterine; Matrin; Matrix Metalloproteinase 7; mmp-7; mmp 7; mmp7; MPSL1; PUMP 1; Pump 1 protease; PUMP1; Uterine Matrilysin; Uterine metalloproteinase; mmp7_HUMAN.	WB; ELISA; IHC-P; IHC-F; IF	Human, Mouse(predicted: Rat)
MMP7 Antibody is an unconjugated, approximately 30 kDa, rabbit-derived, anti-MMP7 polyclonal antibody. MMP7 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, and predicted: rat background without labeling.

HY-P82937

MMP11 Antibody (YA2682)

mmp11; STMY3; Stromelysin-3; SL-3; ST3; Matrix metalloproteinase-11; mmp-11
WB, IHC-P, ICC/IF Human, Mouse, Rat

HY-P80755

MMP12 Antibody Macrophage metalloelastase; MME; 3.4.24.65; Macrophage elastase; ME; hME; Matrix metalloproteinase-12; mmp-12; mmp12; HME	WB, IP	Human, Rat, Hamster
MMP12 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 54 kDa, targeting to MMP12. It can be used for WB,IP assays with tag free, in the background of Human, Rat, Hamster.

HY-P80425

MMP9 Antibody (YA285)	WB, ICC/IF, IHC-P, FC	Human, Rat
MMP9 Antibody (YA285) is a non-conjugated and Rabbit origined monoclonal antibody about 78 kDa, targeting to MMP9. It can be used for WB,ICC/IF,IHC-P,FC assays with tag free, in the background of Human, Rat.

HY-P80756

MMP9 Antibody mmp9; CLG4B; Matrix metalloproteinase-9; mmp-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; GELB	WB, IHC-P, ICC/IF	Human, Mouse, Rat
MMP9 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 78 kDa, targeting to MMP9. It can be used for WB,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P83285

MMP8 Antibody (YA3030)

HNC; CLG1; mmp-8; PMNL-CL; COLLAGENASE I; NEUTROPHIL; matrix metalloproteinase 8
WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat
HY-P83495

MMP26 Antibody (YA3240)

Matrix metalloproteinase-26; Endometase; Matrilysin-2
WB Human, Hamster, Rat

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