1. Metabolic Enzyme/Protease
  2. MMP
  3. NSC 405020

NSC 405020 

Cat. No.: HY-15827 Purity: 99.01%
Handling Instructions

NSC 405020 is a novel small molecule inhibitor of MT1-MMP that specifically targets PEX domain rather than the catalytic domain of MT1-MMP with IC50 >100 μM and does not inhibit the catalytic activity of MT1-MMP or MMP-2.

For research use only. We do not sell to patients.

NSC 405020 Chemical Structure

NSC 405020 Chemical Structure

CAS No. : 7497-07-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
10 mg USD 72 In-stock
Estimated Time of Arrival: December 31
50 mg USD 264 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

NSC 405020 is a novel small molecule inhibitor of MT1-MMP that specifically targets PEX domain rather than the catalytic domain of MT1-MMP with IC50 >100 μM and does not inhibit the catalytic activity of MT1-MMP or MMP-2. IC50 value: > 100 uM [1] Target: MT1-MMP PEX inhibitor NSC-405020 directly interacts with and binds to PEX in a vicinity of Met-328, Arg-330, Asp-376, Met-22 and Ser-470 of the druggable pocket in the full-length MT1-MMP structure, which affects the conformation and flexibility of blades I to IV of the β-propeller resulting in the decrease of the PEX-dependent homodimerization of cellular MT1-MMP. NSC-405020 dose not affect the ability of MT1-MMP to activate MMP-2 but its ability to degrade COL-I.

Molecular Weight

260.16

Formula

C₁₂H₁₅Cl₂NO

CAS No.

7497-07-6

SMILES

O=C(NC(C)CCC)C1=CC=C(Cl)C(Cl)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 260 mg/mL (999.38 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8438 mL 19.2189 mL 38.4379 mL
5 mM 0.7688 mL 3.8438 mL 7.6876 mL
10 mM 0.3844 mL 1.9219 mL 3.8438 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.61 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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KeyWords:

NSC 405020 | NSC405020 | NSC-405020 | MMP | Matrix metalloproteinases | Inhibitor | inhibitor | inhibit

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Product name:
NSC 405020
Cat. No.:
HY-15827
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