7497-07-6
7497-07-6
Chemical Structure
NSC 405020
- CAS No.: 7497-07-6
- Formula:C12H15Cl2NO
- Molecular Weight:260.16
IUPAC Name: 3,4-dichloro-N-(pentan-2-yl)benzamide
InChIKey: ARDYECYBETXQFD-UHFFFAOYSA-N
SMILES: O=C(NC(C)CCC)C1=CC=C(Cl)C(Cl)=C1
Biological Activity: NSC 405020 is a specific MMP14 inhibitor. NSC 405020 can directly interact with the hemopexin domain of MMP14. NSC 405020 reduces the expression of full length and active cleaved Notch3 (NICD3). NSC 405020 can be used to research vestibular schwannoma, hemostasis and thrombosis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NSC 405020 | 99.63% | NSC 405020 is a specific MMP14 inhibitor. NSC 405020 can directly interact with the hemopexin domain of MMP14. NSC 405020 reduces the expression of full length and active cleaved Notch3 (NICD3). NSC 405020 can be used to research vestibular schwannoma, hemostasis and thrombosis. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.71
HY-100377Lvguidingan -
Similarity Score 0.71
HY-W052512Antitrypanosomal agent 1 -
Similarity Score 0.70
HY-1650191-(3,4-Dichlorophenyl)-2-(dimethylamino)-1-propanone hydrochloride -
Similarity Score 0.70
HY-W721367Bupropion impurity 4 -
Similarity Score 0.67
HY-W046349N,N-didesmethyl AH 7921 -
Similarity Score 0.66
HY-111193Declopramide -
Similarity Score 0.66
HY-111193ADeclopramide hydrochloride -
Similarity Score 0.65
HY-13733AProcarbazine -
Similarity Score 0.65
HY-N18038Zoxamide metabolite 1 -
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References
- [1]. Ren Y, et al. MMP-14 (MT1-MMP) Is a Biomarker of Surgical Outcome and a Potential Mediator of Hearing Loss in Patients With Vestibular Schwannomas. Front Cell Neurosci. 2020 Jul 28;14:191. [Content Brief]
- [2]. Pekkonen P, et al. Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation. Elife. 2018 May 1;7:e32490. [Content Brief]
- [3]. Mastenbroek TG, et al. Platelet-Associated Matrix Metalloproteinases Regulate Thrombus Formation and Exert Local Collagenolytic Activity. Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2554-61. [Content Brief]
