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Cat. No.: HY-W721367

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Bupropion impurity 4

Bupropion impurity 4 is an impurity of Bupropion.

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CAS No.: 1193779-34-8
Formule: C₁₃H₁₇Cl₂NO
Masse moléculaire:274.19

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (238 KB)

Bupropion impurity 4 Chemical Structure

CAS No.: 1193779-34-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
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- Cellular Effect
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Activité biologique

Description

Bupropion impurity 4 is an impurity of Bupropion.

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	>10 μM Compound: 1j	Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells Inhibition of [3H]serotonin reuptake at human SERT expressed in HEK293 cells	[PMID: 19821577]
HEK293	IC₅₀	1670 nM Compound: 2k	Inhibition of [3H]norepinephrine uptake at human NET expressed in HEK293 cells Inhibition of [3H]norepinephrine uptake at human NET expressed in HEK293 cells	[PMID: 20158204]
HEK293	IC₅₀	2100 nM Compound: 1j	Inhibition of [3H]norepinephrine reuptake at human NET expressed in HEK293 cells Inhibition of [3H]norepinephrine reuptake at human NET expressed in HEK293 cells	[PMID: 19821577]
HEK293	IC₅₀	271 nM Compound: 1j	Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK293 cells Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK293 cells	[PMID: 19821577]
HEK293	IC₅₀	463 nM Compound: 2k	Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cells Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cells	[PMID: 20158204]
HEK293	IC₅₀	8800 nM Compound: 2k	Inhibition of [3H]serotonin uptake at human SERT expressed in HEK293 cells Inhibition of [3H]serotonin uptake at human SERT expressed in HEK293 cells	[PMID: 20158204]
SH-SY5Y	IC₅₀	12 nM Compound: 2k	Antagonist activity at human alpha4beta4 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ efflux by liquid scintillation counting Antagonist activity at human alpha4beta4 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ efflux by liquid scintillation counting	[PMID: 20158204]
SH-SY5Y	IC₅₀	29 nM Compound: 2k	Antagonist activity at human alpha4beta2 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ efflux by liquid scintillation counting Antagonist activity at human alpha4beta2 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ efflux by liquid scintillation counting	[PMID: 20158204]
SH-SY5Y	IC₅₀	6.8 nM Compound: 2k	Antagonist activity at alpha3beta4 nAChR receptor in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ efflux by liquid scintillation counting Antagonist activity at alpha3beta4 nAChR receptor in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ efflux by liquid scintillation counting	[PMID: 20158204]

Chemical Information

CAS No. 1193779-34-8
Masse moléculaire 274.19
Formule C₁₃H₁₇Cl₂NO
SMILES

O=C(C1=CC=C(Cl)C(Cl)=C1)C(NC(C)(C)C)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.