10-Butyl Ether Minocycline
10-Butyl Ether Minocycline (BEM), a Minocycline (HY-17412A) derivative, is an MMP-8 and MMP-9 inhibitor with IC50s of 69.4 µM and 47.0 µM, respectively. 10-Butyl Ether Minocycline suppresses LPS (HY-D1056)-induced microglial activation. 10-Butyl Ether Minocycline inhibits VEGF-induced endothelial cell migration and L-Glutamine (HY-N0390)-induced ROS levels. 10-Butyl Ether Minocycline significantly reduces alcohol consumption in the Chronic Intermittent Ethanol (CIE) mouse model of alcohol dependence. 10-Butyl Ether Minocycline can be used for the study of neuroimmune-inflammatory diseases and Alcohol use disorder (AUD).
For research use only. We do not sell to patients.
- CAS No.: 488815-65-2
- Formula: C27H35N3O7
- Molecular Weight:513.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
10-Butyl Ether Minocycline (1.56-100 µg/mL) shows a nearly complete loss of antimicrobial activity against E. coli, S. typhi, and C. albicans[1].
10-Butyl Ether Minocycline (0.1-500 µM, 24 h) demonstrates a dose-dependent reduction in NB cell viability with an IC50 of 102.1 µM[1].
10-Butyl Ether Minocycline (25 µM, 12 h) suppresses LPS (HY-D1056)-mediated microglial activation in N9 microglial cells[1].
10-Butyl Ether Minocycline (100 µM, 12 h) inhibits VEGF-induced endothelial cell migration in HUVECs[1].
10-Butyl Ether Minocycline (30-120 µM) attenuates L-Glutamine (HY-N0390)-induced ROS production dose-dependently in N9 microglial cells[1].
10-Butyl Ether Minocycline (30-120 µM) inhibits 15-LOX with IC50s of 92.6 µM[1].
10-Butyl Ether Minocycline (30-120 µM) does not exhibit significant mitochondrial toxicity compared to sodium azide in Human Colorectal Tumor (HCT) 116 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:N9 microglial cells
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Concentration:25 µM
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Incubation Time:12 h
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Result:Reduced Iba1 expression in LPS-activated N9 microglial cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Chronic Intermittent Ethanol (CIE) C57BL/6J mice (8 weeks)[1]
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Dosage:60 mg/kg
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Administration:i.p. 2 hours before voluntary ethanol consumption
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Result:Showed a significant reduction in alcohol consumption.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 488815-65-2
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Molecular Weight 513.58
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Formula C27H35N3O7
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SMILES
[H][C@@]12C[C@@]3(CC4=C(C=CC(OCCCC)=C4C(C3=C([C@@]1(C(C(C(N)=O)=C([C@H]2N(C)C)O)=O)O)O)=O)N(C)C)[H]
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Synonyms
BEM
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
10-Butyl Ether Minocycline Related Classifications
HY-175275 Related Classifications
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