2. Cell Cycle/DNA Damage Cytoskeleton Metabolic Enzyme/Protease
  3. Microtubule/Tubulin MMP
  4. Tubulin/MMP-IN-1

Tubulin/MMP-IN-1 (compound 15g) is a potent inhibitor of tubulin and MMP. Tubulin/MMP-IN-1 has the potential for the research of cancer diseases. Tubulin/MMP-IN-1 suppresses tubulin polymerization, induces cell cycle arrest at the G2/M phase, leads to reactive oxidative stress (ROS) generation of HepG2 cells, and results in apoptosis by the mitochondrial-dependent apoptotic pathway.

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Tubulin/MMP-IN-1

Tubulin/MMP-IN-1 Chemische Struktur

CAS. Nr. : 3034896-75-5

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Tubulin/MMP-IN-1 Related Antibodies

Top Publications Citing Use of Products

Alle MMP Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8 MMP-19

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Beschreibung

Tubulin/MMP-IN-1 (compound 15g) is a potent inhibitor of tubulin and MMP. Tubulin/MMP-IN-1 has the potential for the research of cancer diseases. Tubulin/MMP-IN-1 suppresses tubulin polymerization, induces cell cycle arrest at the G2/M phase, leads to reactive oxidative stress (ROS) generation of HepG2 cells, and results in apoptosis by the mitochondrial-dependent apoptotic pathway[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
0.68 μM
Compound: 15g
Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay
[PMID: 35551039]
HepG2 IC50
0.05 μM
Compound: 15g
Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay
[PMID: 35551039]
L02 IC50
0.14 μM
Compound: 15g
Antiproliferative activity against human L02 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human L02 cells measured after 48 hrs by MTT assay
[PMID: 35551039]
MCF7 IC50
0.45 μM
Compound: 15g
Antiproliferative activity against human MCF7 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells measured after 48 hrs by MTT assay
[PMID: 35551039]
Molekulargewicht

689.73

Formel

C38H44NO9P
CAS. Nr.
SMILES

CCOP(OCC)(C(C1=CC=CC=C1C)NC2=CC=C(C=C2)CC(OC3=CC(/C=C\C4=CC(OC)=C(C(OC)=C4)OC)=CC=C3OC)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
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Tubulin/MMP-IN-1 Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin/MMP-IN-13034896-75-5Microtubule/TubulinMMPMatrix metalloproteinasestubulincancertubulin polymerizationcell cycleG2/M phaseROSmitochondrial-dependentInhibitorinhibitorinhibit

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