Tubulin/MMP-IN-1
Tubulin/MMP-IN-1 (compound 15g) is a potent inhibitor of tubulin and MMP. Tubulin/MMP-IN-1 has the potential for the research of cancer diseases. Tubulin/MMP-IN-1 suppresses tubulin polymerization, induces cell cycle arrest at the G2/M phase, leads to reactive oxidative stress (ROS) generation of HepG2 cells, and results in apoptosis by the mitochondrial-dependent apoptotic pathway.
For research use only. We do not sell to patients.
- CAS No.: 3034896-75-5
- Formula: C38H44NO9P
- Molecular Weight:689.73
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.68 μM
Compound: 15g
|
Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells measured after 48 hrs by MTT assay
|
[PMID: 35551039] |
| HepG2 | IC50 |
0.05 μM
Compound: 15g
|
Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells measured after 48 hrs by MTT assay
|
[PMID: 35551039] |
| L02 | IC50 |
0.14 μM
Compound: 15g
|
Antiproliferative activity against human L02 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human L02 cells measured after 48 hrs by MTT assay
|
[PMID: 35551039] |
| MCF7 | IC50 |
0.45 μM
Compound: 15g
|
Antiproliferative activity against human MCF7 cells measured after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells measured after 48 hrs by MTT assay
|
[PMID: 35551039] |
Chemical Information
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CAS No. 3034896-75-5
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Molecular Weight 689.73
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Formula C38H44NO9P
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SMILES
CCOP(OCC)(C(C1=CC=CC=C1C)NC2=CC=C(C=C2)CC(OC3=CC(/C=C\C4=CC(OC)=C(C(OC)=C4)OC)=CC=C3OC)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)