CA IX-IN-2
CA IX-IN-2 (Compound 9o) is an inhibitor for carbonic anhydrase (CA), that inhibits CA IX, CA XII and CA II with an IC50 of 5.6, 7.4 and 430 nM, respectively. CA IX-IN-2 inhibits the proliferation of cancer cell HCT-116, SW480, MDA-MB 231 and MCF-7, with IC50s of 14.63-29.33 μM. CA IX-IN-2 intercalates DNA, arrests cell cycle at G1/S phase, and induces apoptosis in MDA-MB-231. CA IX-IN-2 affects the mitochondrial membrane potential (MMP), increases the intracellular ROS levels, causes mitochondrial damage, and inhibits the cell migration of MDA-MB-231. CA IX-IN-2 exhibits antitumor efficacy in mouse models.
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- CAS. Nr.: 3009842-92-3
- Formel: C30H36N6O5S
- Molecular Weight:592.71
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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CA IX 5.6 nM (IC50) |
CA XII 7.4 nM (IC50) |
CA Ⅱ 430 nM (IC50) |
Chemical Information
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CAS. Nr. 3009842-92-3
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Molecular Weight 592.71
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Formel C30H36N6O5S
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SMILES
O=C(C1=CC=C(C2=CC=CC(C3=O)=C12)N4CCN(CC4)CC(NC5=CC=C(C=C5)S(N)(=O)=O)=O)N3CCN(CC)CC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CA IX-IN-2 Related Classifications
HY-159122 Related Classifications
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