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MMP14 Antibody (YA1590)

(Synonyms: MMP-14; MMP-X1; MT-MMP; MT1MMP; MTMMP1; WNCHRS; MT1-MMP; MT-MMP 1)
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MMP14 Antibody (YA1590) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MMP14.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IHC-P, ICC/IF, FC, IP

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

  • Conjugation:
    Non-conjugated
  • MMP14 Antibody (YA1590) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
IP Info
IP: Immunoprecipitation
Dilution Ratio 1:1000-1:5000 1:50-1:100 1:100-1:200 1:100-1:200 1:20

Product Details

Description

MMP14 Antibody (YA1590) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MMP14.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 66 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 66 kDa
Species Reactivity Database

Entrez Gene: 4323 Human ;

SwissProt: P50281 Human ;

Immunogen

A synthetic peptide of human MMP14 aa161-174.

Sensitivity

Endogenous

Purification

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    MMP-14 (MT1-MMP, membrane-type 1 matrix metalloproteinase) is a membrane-anchored zinc-dependent endopeptidase that regulates pericellular extracellular matrix (ECM) remodeling by degrading fibrillar collagens, fibronectin, laminins, and other matrix components, thereby controlling cell migration, tissue remodeling, and developmental processes[5][1]. Mechanistically, MMP-14 functions at the cell surface and is a major activator of proMMP-2 through the well-characterized proMMP-2/TIMP-2/MMP-14 complex, linking localized proteolysis to invasive cellular behavior and matrix turnover[5][2]. Through direct ECM degradation and activation of additional protease cascades, MMP-14 promotes cellular invasion, angiogenesis, and tissue remodeling in both physiological and pathological settings[5][1][3]. In disease models, elevated MMP-14 expression is associated with tumor progression, invasion, metastasis, and poor clinical outcome across multiple cancer types, including ovarian carcinoma and other solid tumors[3][4]. Genetic studies further demonstrate the unique biological importance of MMP-14, as MMP-14-deficient mice develop severe craniofacial abnormalities, osteopenia, fibrosis, dwarfism, and impaired tissue homeostasis, highlighting functions that are not fully compensated by other MMP family members[5][1]. Compared with related membrane-type MMP isoforms, MMP-14 is the best-characterized transmembrane collagenase and is distinguished by its potent pericellular collagenolytic activity, essential role in proMMP-2 activation, and ability to drive invasion within collagen-rich matrices[5][1]. For experimental applications, MMP-14 is widely used as a mechanistic target for studying ECM remodeling, tumor invasion, angiogenesis, and protease-dependent signaling pathways, and selective inhibition of MMP-14 remains an active area of therapeutic research[5][3].

  • Subcellular Localization

    Cell membrane; Single-pass type I membrane protein; Melanosome; Cytoplasm

  • Expression


    Tissue_specificity:Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors

    Induction:Up-regulated by NANOS1

  • Subunit

    Interacts (via C-terminal cytoplasmic tail) with BST2

  • SwissProt ID

    P50281

  • Gene ID
    4323 [NCBI]
  • Synonyms

    MMP-14; MMP-X1; MT-MMP; MT1MMP; MTMMP1; WNCHRS; MT1-MMP; MT-MMP 1

  • Research Field

    Cardiovascular

[1]. MMP-14 gene information.

[2]. Bertholon J, et al. Chfr inactivation is not associated to chromosomal instability in colon cancers. Oncogene. 2003 Dec 4;22(55):8956-60. [Content Brief]

[3]. Vos MC, et al. The role of MMP-14 in ovarian cancer: a systematic review. J Ovarian Res. 2021;14(1):101. [Content Brief]

[4]. Li M, et al. Immune Infiltration of MMP14 in Pan Cancer and Its Prognostic Effect on Tumors. Front Oncol. 2021 Sep 17;11:717606. [Content Brief]

[5]. Kelly H, et al. The Diverse Pathways for Cell Surface MT1-MMP Localization in Migratory Cells. Cells. 2025;14(3):209.

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MMP14 Antibody (YA1590) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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