MMP14 - matrix metallopeptidase 14 Gene

Also Known as MMP-14; MMP-X1; MT-MMP; MT1MMP; MTMMP1; WNCHRS; MT1-MMP; MT-MMP 1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4323

About MMP14

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:22,836,585-22,847,758 (from NCBI)

This gene has 8 transcripts (splice variants), 272 orthologues, 23 paralogues and is associated with 3 phenotypes. Broad expression in endometrium (RPKM 130.9), gall bladder (RPKM 96.0) and 20 other tissues.

Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]

MMP14 Products (1)

mRNA	Protein	Name
NM_004995.4	NP_004986.1	matrix metalloproteinase-14 preproprotein

MMP14 Protein Structure

PG_binding_1

Peptidase_M10

Hemopexin

DUF3377

0
100
200
300
400
500
582 a.a.

Protein Preferred Names	Protein Names
matrix metalloproteinase-14	matrix metallopeptidase 14 (membrane-inserted) membrane type 1 metalloprotease membrane-type-1 matrix metalloproteinase

MMP14 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MMP14	P50281	TIMP2	Homo sapiens	P16035	Anti Tag CoIP	33961781
Intra	MMP14	P50281	TIMP2	Homo sapiens	P16035	Anti Bait CoIP	24112707
Intra	MMP14	P50281	FURIN	Homo sapiens	P09958	Anti Bait CoIP	21152186
Intra	MMP14	P50281	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	MMP14	P50281	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	MMP14	P50281	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	MMP14	P50281	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	MMP14	P50281	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	MMP14	P50281	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	MMP14	P50281	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	MMP14	P50281	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
Intra	MMP14	P50281	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	MMP14	P50281	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	MMP14	P50281	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	MMP14	P50281	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
Intra	MMP14	P50281	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	MMP14	P50281	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	MMP14	P50281	LIMK1	Homo sapiens	P53667	Anti Bait CoIP	21219645
Intra	MMP14	P50281	LIMK1	Homo sapiens	P53667	IF	21219645
Intra	MMP14	P50281	BCAR1	Homo sapiens	P56945	Anti Bait CoIP	18164686
Intra	MMP14	P50281	BCAR1	Homo sapiens	P56945	IF	18164686
Intra	MMP14	P50281	FHL3	Homo sapiens	Q13643	Validated Y2H	32296183
Intra	MMP14	P50281	FHL3	Homo sapiens	Q13643	Y2H Array	32296183
Intra	MMP14	P50281	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	32296183
Intra	MMP14	P50281	F11R	Homo sapiens	Q9Y624	Y2H Prey Pooling	32296183
Intra	MMP14	P50281	F11R	Homo sapiens	Q9Y624	Validated Y2H	32296183
Intra	MMP14	P50281	F11R	Homo sapiens	Q9Y624	Y2H Array	32296183
Intra	MMP14	P50281	ZUP1	Homo sapiens	Q96AP4	Y2H Array	32296183
Intra	MMP14	P50281	ZUP1	Homo sapiens	Q96AP4	Validated Y2H	32296183
Intra	MMP14	P50281	ZUP1	Homo sapiens	Q96AP4	Y2H Prey Pooling	32296183
Intra	MMP14	P50281	MSMO1	Homo sapiens	Q15800	Validated Y2H	32296183
Intra	MMP14	P50281	MSMO1	Homo sapiens	Q15800	Y2H Prey Pooling	32296183
Intra	MMP14	P50281	MSMO1	Homo sapiens	Q15800	Y2H Array	32296183
Intra	MMP14	P50281	ADI1	Homo sapiens	Q9BV57	Anti Tag CoIP	14718544
Intra	MMP14	P50281	ADI1	Homo sapiens	Q9BV57	Y2H	14718544
Cross	MMP14	P50281	Gorasp2	Rattus norvegicus	Q9R064	Y2H	20608975

Cross: Cross-species interaction Intra: Intraspecies interaction

MMP14 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81845	MMP14 Antibody (YA1590)	WB, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat
HY-P81845A	MMP14 Antibody (YA1590)(PBS only)	WB, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Multicentric Osteolysis-Nodulosis-Arthropathy Spectrum	Mona Spectrum Nao Syndrome Nodulosis-Arthropathy-Osteolysis Syndrome Torg-Winchester Syndrome Multicentric Osteolysis-Nodulosis-Arthropathy Spectrum Disorders
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Hyperostosis	Hypertrophy Of Bone Bone Hypertrophy Bone Thickening Periosteum Thickening
Rhabdomyosarcoma
Frank-Ter Haar Syndrome	Ter Haar Syndrome Borrone Dermatocardioskeletal Syndrome FTHS Autosomal Recessive Melnick-Needles Syndrome Borrone Di Rocco Crovato Syndrome Megalocornea, Multiple Skeletal Anomalies, And Developmental Delay Melnick-Needles Syndrome, Autosomal Recessive, Formerly Frank Ter Haar Syndrome
High Grade Glioma	Malignant Glioma Glial Cell Tumor Glioma, Malignant Malignant Neuroglial Tumor Neuroglial Tumor Glioma Malignant Gliomas
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Aortic Aneurysm, Familial Abdominal, 1	Abdominal Aortic Aneurysm Aortic Aneurysm, Familial Abdominal 1 Aneurysm, Abdominal Aortic AAA Aortic Aneurysm, Abdominal AAA1 Aortic Aneurysm, Familial Abdominal Aortic Aneurysm Abdominal Abdominal Aortic Aneurysms Abdominal Aortic Aneurysm Without Mention Of Perforation Or Rupture Abdomen Aneurysm Abdominal Aorta Aneurysm Aneurysm Of Abdominal Aorta Aortic Abdomen Aneurysm Aaa - [Abdominal Aortic Aneurysm] Abdominal Aneurysm Abdominal Aorta Aneurysm Rupture Abdominal Aorta Aneurysm Ruptured Abdominal Aortic Aneurysm Which Has Ruptured Ruptured Aaa Abdomen Aorta Aneurysm Ruptured Abdomen Aorta Rupture Abdomen Aortic Aneurysm Rupture Abdomen Aneurysm Rupture Abdomen Aortic Aneurysm Ruptured Abdomen Aortic Rupture Abdominal Aorta Rupture Abdominal Aortic Rupture Rupture Abdomen Aorta Aneurysm Rupture Abdominal Aortic Aneurysm Ruptured Abdomen Aneurysm Ruptured Abdomen Aorta Ruptured Abdomen Aortic Ruptured Abdominal Aneurysm Ruptured Abdominal Aorta Ruptured Abdominal Aortic Ruptured Aorta Abdominalis Aneurysm False Abdomen Aorta Aneurysm Ruptured False Abdominal Aortic Aneurysm Ruptured False Abdominal Aorta Aneurysm Ruptured False Abdomen Aortic Aneurysm Ruptured
Cervical Squamous Cell Carcinoma	Squamous Cell Carcinoma Of The Cervix Uteri Squamous Cell Carcinoma Of Cervix
Otopalatodigital Syndrome Spectrum Disorder	Opd Spectrum Disorder Opsd Fronto-Otopalatodigital Osteodysplasia
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Keratoconus	Kc Conical Cornea Noninflammatory Corneal Thining Bulging Cornea Cornea Conical Acquired Conus Of Cornea
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Gastric Cancer	Stomach Cancer Stomach Carcinoma Gastric Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Larynx Cancer	Laryngeal Carcinoma Carcinoma Of Larynx Laryngeal Cancer Laryngeal Neoplasm Malignant Neoplasm Of Larynx Cancer Of Larynx Laryngeal Neoplasms Cancer, Laryngeal
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma
Amyloidosis, Finnish Type	Finnish Type Amyloidosis Meretoja Syndrome Amyloidosis V Amyloidosis, Meretoja Type Amyloid Cranial Neuropathy With Lattice Corneal Dystrophy Lattice Corneal Dystrophy Type Ii Familial Amyloid Polyneuropathy Type Iv Amyloidosis Due To Mutant Gelsolin Agel Amyloidosis Gelsolin Amyloidosis Familial Amyloidosis, Finnish Type Hereditary Gelsolin Amyloidosis Lattice Corneal Dystrophy Type Ii Finnish Gelsolin-Related Amyloidosis Kymenlaakso Syndrome Lattice Corneal Dystrophy, Gelsolin Type Hereditary Amyloidosis, Finnish Type Lattice Corneal Dystrophy Type 2 Amyloidosis 5 AMYL5 Agel Familial Amyloidosis Finnish Type Meretoja Type Amyloidosis Type Iv Familial Amyloid Polyneuropathy Familial Amyloid Polyneuropathy, Type V Familial Amyloid Polyneuropathy, Type Iv
Winchester Syndrome	WNCHRS Winchester Disease Winchester-Grossman Syndrome
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Breast Intraductal Papillomatosis	Breast Papillomatosis Intraductal Papillomatosis Of The Breast
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta
Marfan Syndrome	MFS Mfs1 Marfan'S Syndrome Marfan Syndrome Type 1 Marfan Syndrome, Type I Mass Phenotype Contractural Arachnodactyly Mass Syndrome Octd Overlap Connective Tissue Disease Marfanoid Hypermobility Syndrome Marfan Disease
Brain Cancer	Malignant Neoplasm Of Brain Adult Brain Tumor Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Serous Cystadenocarcinoma	Serous Adenocarcinoma Cystadenocarcinoma, Serous Serous Carcinoma Cystadenocarcinoma Serous
Malignant Pleural Mesothelioma	Malignant Mesothelioma Of Pleura Pleural Malignant Mesothelioma
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Spinal Cord Vascular Diseases Vascular Tissue Disease Vascular Anomaly
Melanoma In Congenital Melanocytic Nevus	Malignant Melanoma In Congenital Melanocytic Nevus Melanocytic Nevi Nevi Melanocytic
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Primary Cutaneous Amyloidosis	Plca Primary Localized Cutaneous Amyloidosis Familial Primary Localized Cutaneous Amyloidosis Amyloidosis Ix Lichen Amyloidosis Familial Amyloidosis, Primary Cutaneous Pca Amyloidosis 9 Amyloidosis Familial Cutaneous Lichen Fplca Familial Lichen Amyloidosis
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Head And Neck Cancer Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Cancer, Head/Neck Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Supraglottis Cancer	Malignant Tumor Of Supraglottis Ca Larynx - Supraglottis Malignant Neoplasm Of Extrinsic Larynx Malignant Neoplasm Of Supraglottis Malignant Supraglottic Tumor Supraglottis Neoplasm Of Supraglottis
Lymphangioleiomyomatosis	Lymphangiomyomatosis LAM Lung Lymphangioleiomyomatosis Pulmonary Lymphangioleiomyomatosis Lymphangioleiomyomatosis, Somatic Lymphangio-Myomatosis
Chondrosarcoma	Cartilaginous Cancer Chondrosarcoma Of Bone Primary Chondrosarcoma Of The Bone CHDSA

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12169	Marimastat	Inhibitor	99.81%	Phase 3

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990045	Lixudebart	Inhibitor	98.88%	Phase 2

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15827	NSC 405020	Inhibitor	99.63%	Unkown
HY-110397	KP-457	Inhibitor	98.88%	Unkown
HY-107394	UK 356618	Inhibitor	98.91%	Unkown
HY-124373	ND-336	Inhibitor	97.16%	Unkown
HY-162038	RXP03	Inhibitor	98.82%	Unkown
HY-107639	UK-370106	Inhibitor	≥99.0%	Unkown
HY-E70290	N-Acetylgalactosaminyltransferase 1	Agonist	/	Unkown
HY-110397G	KP-457 (GMP)	Inhibitor	/	Unkown
HY-114785	BPHA	Inhibitor	99.88%	Unkown
HY-RS08528	MMP14 Human Pre-designed siRNA Set A		/	Unkown
HY-P3120	Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2	Substrate	96.30%	Unkown
HY-124373A	(R)-ND-336	Inhibitor	/	Unkown
HY-160720	ASPH-IN-1	Inhibitor	/	Unkown
HY-P3120A	Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 TFA	Substrate	/	Unkown
HY-RS08529	Mmp14 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08530	Mmp14 Rat Pre-designed siRNA Set A		/	Unkown
HY-35513	3-Aminobenzene-1,2-diol	Inhibitor	98.0%	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991316	KD014		96.98%	Unkown
HY-P991478	RLVT-14-02	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MMP14	VGNC	VGNC:43277
Mus musculus	MMP14	MGD	MGI:101900
Rattus norvegicus	MMP14	RGD	RGD:620198
Felis catus	MMP14	VGNC	VGNC:68282
Macaca mulatta	MMP14	VGNC	VGNC:74892
Bos taurus	MMP14	VGNC	VGNC:31519
Others	MMP14	NCBI