ZUP1 - zinc finger containing ubiquitin peptidase 1 Gene

Also Known as DUB; ZUFSP; C6orf113

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 221302

About ZUP1

This gene has 4 transcripts (splice variants), 133 orthologues and 6 paralogues. Ubiquitous expression in duodenum (RPKM 4.7), bone marrow (RPKM 4.6) and 25 other tissues.

Summary

This gene encodes a protein containing zinc finger motifs and a cysteine peptidase domain. The encoded protein functions as a K63-specific de-ubiquitinating enzyme that specifically cleaves long K63-linked polyubiquitin chains in the middle of a chain (i.e. "endo cleavage) rather than by removing the terminal ubiquitin from a chain. This enzyme is thought to be involved in the regulation of DNA repair by cleaving K63-linked ubiquitin chains at repair foci. This protein is related to proteases for the ubiquitin-like modifiers Ufm1 (ubiquitin fold modifier 1) and Atg8/Gabarapl2, but does not have any activity on these modifiers. [provided by RefSeq, Mar 2018]

ZUP1 Products (4)

mRNA	Protein	Name
NM_001361189.2	NP_001348118.1	zinc finger-containing ubiquitin peptidase 1 isoform 1
NM_001361190.2	NP_001348119.1	zinc finger-containing ubiquitin peptidase 1 isoform 2
NM_001361191.2	NP_001348120.1	zinc finger-containing ubiquitin peptidase 1 isoform 3
NM_145062.3	NP_659499.2	zinc finger-containing ubiquitin peptidase 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZUP1 Protein Structure

zf-C2H2_4

Peptidase_C78

0
100
200
300
400
500
578 a.a.

Protein Preferred Names	Protein Names
zinc finger-containing ubiquitin peptidase 1	lys-63-specific deubiquitinase ZUFSP

ZUP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZUP1	Q96AP4	RPS21	Homo sapiens	Q8WVC2	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Machado-Joseph Disease	SCA3 MJD Spinocerebellar Ataxia 3 Azorean Disease Spinocerebellar Ataxia Type 3 Spinocerebellar Atrophy Azorean Neurologic Disease Spinopontine Atrophy Nigrospinodentatal Degeneration Spinocerebellar Atrophy Iii Spinocerebellar Atrophy Type 3 Azorean Ataxia Azorean Disease Of The Nervous System Machado Disease Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia Disease, Machado-Joseph Ataxia, Spinocerebellar
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16207	ZUP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22363	Zup1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28887	Zup1 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ZUP1	VGNC	VGNC:37389
Mus musculus	ZUP1	MGD	MGI:1919830
Felis catus	ZUP1	VGNC	VGNC:67388
Rattus norvegicus	ZUP1	RGD	RGD:1307672
Macaca mulatta	ZUP1	VGNC	VGNC:79317
Canis familiaris	ZUP1	VGNC	VGNC:48863
Others	ZUP1	NCBI