2. Metabolic Enzyme/Protease Apoptosis
  3. MMP Apoptosis
  4. Nudol

Nudol is a phenanthrene compound that has anti-cancer activity. Nudol inhibits cell proliferation, induces cell apoptosis. Nudol inhibits MMP-2M and MMP-9 activity (Ki: 988.9 nM, 1.76 μM, respectively). Nudol can be used in the research of cancers, such as osteosarcoma.

For research use only. We do not sell to patients.

Nudol Chemical Structure

Nudol Chemical Structure

CAS No. : 86630-46-8

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Nudol Related Antibodies

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

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Description

Nudol is a phenanthrene compound that has anti-cancer activity. Nudol inhibits cell proliferation, induces cell apoptosis. Nudol inhibits MMP-2M and MMP-9 activity (Ki: 988.9 nM, 1.76 μM, respectively). Nudol can be used in the research of cancers, such as osteosarcoma[1][2].

IC50 & Target[2]

MMP-2

988.9 nM (Ki)

MMP-9

1.76 μM (Ki)

In Vitro

Nudol (0-40 μM, 24-72 h) decreases cell viability in several cancer cell lines[1].
Nudol (0-20 μM, 24/48 h) suppresses the cell migration and causes cell cycle arrest at G2/M phase in U2OS cells[1].
Nudol (20 μM, 48 h) induces cell apoptosis through the caspase-dependent pathway in U2OS cells[1].
Nudol (compound 4) inhibits MMP-2 and MMP-9 activity with Ki values of 988.9 nM and 1.76 μM respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nudol Related Antibodies

Cell Viability Assay[1]

Cell Line: U2OS, MG63, MDA-MB-231, MCF-7, and A549 cells
Concentration: 0, 10, 20, 30, 40 μM
Incubation Time: 24, 48, and 72 h
Result: Decreased the cell viability of osteosarcoma cells in dose- and time-dependent manners.

Cell Cycle Analysis[1]

Cell Line: U2OS cells
Concentration: 0, 5, 10, 20 μM
Incubation Time: 24, 48, and 72 h
Result: Triggered G2/M phase arrest by decreasing cell cycle-related proteins (CDK1, CDK2, CDK4, and CDK10).

Western Blot Analysis[1]

Cell Line: U2OS cells
Concentration: 0, 5, 10, 20, 40 μM
Incubation Time: 24, 48, and 72 h
Result: Increased the protein level of cytochrome c.
Down-regulated anti-apoptotic Bcl-2, accompanied by an increased level of pro-apoptotic Bax.
Molecular Weight

270.28

Formula

C16H14O4
CAS No.
SMILES

OC1=C(OC)C(OC)=C2C3=CC=C(O)C=C3C=CC2=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Nudol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nudol86630-46-8MMPApoptosisMatrix metalloproteinasesAnti-proliferationphenanthreneanti-tumoranti-cancerosteosarcomaU2OSapoptosisInhibitorinhibitorinhibit

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