1. Metabolic Enzyme/Protease
  2. MMP
  3. CP-471474

CP-471474 

Cat. No.: HY-W011085
Handling Instructions

CP-471474 is an orally active and pan MMP inhibitor, with IC50 values of 1170 nM (MMP-1), 0.7 nM (MMP-2), 16 nM (MMP-3), 13 nM (MMP-9) and 0.9 nM (MMP-13), respectively.

For research use only. We do not sell to patients.

CP-471474 Chemical Structure

CP-471474 Chemical Structure

CAS No. : 210755-45-6

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Description

CP-471474 is an orally active and pan MMP inhibitor, with IC50 values of 1170 nM (MMP-1), 0.7 nM (MMP-2), 16 nM (MMP-3), 13 nM (MMP-9) and 0.9 nM (MMP-13), respectively[1][2].

IC50 & Target[1]

MMP-2

0.7 nM (IC50)

MMP-13

0.9 nM (IC50)

MMP-9

13 nM (IC50)

MMP-3

16 nM (IC50)

MMP-1

1170 nM (IC50)

In Vivo

CP-471474 plasma levels following subcutaneous injection are 2,020 ng/mL (1 h postdose) to 160 ng/mL (6 h postdose)[2].
CP-471,474 significantly reduces both the extent and severity of inflammation at 2 months. At 4 months, a spontaneous reduction of the inflammatory response is observed in both treated and untreated animals, and consequently no difference is observed between both[2].
CP-471474 significantly decreases the destructive lesions mainly at 2 months and also at 4 months[2].

Animal Model: Guinea pigs weighing 400 to 450 g (COPD)[2].
Dosage: 20 mg/kg (also supplemented daily by the diet (200 mg/200 g powdered chow)).
Administration: Subcutaneously (in 20% ethanol/80% polyethylene glycol), once a day during the entire course.
Result: Lungs derived from smoking animals treated with the compound demonstrated a statistically significant reduction in the destructive lesions.
Showed an increase of both pro–MMP-9 and its active form (lanes 5 to 8) as compared with control animals.
Molecular Weight

368.38

Formula

C₁₆H₁₇FN₂O₅S

CAS No.

210755-45-6

SMILES

CC(C)(NS(=O)(C1=CC=C(OC2=CC=C(F)C=C2)C=C1)=O)C(NO)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CP-471474CP471474CP 471474MMPMatrix metalloproteinasesCOPDsmokelunginflammationmyocardialinfarctionInhibitorinhibitorinhibit

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CP-471474
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HY-W011085
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