MMP-9-IN-3
MMP-9-IN-3 is a MMP-9 inhibitor (IC50: 5.56 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-3 also inhibits AKT activity (IC50: 2.11 nM). MMP-9-IN-3 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-3 can be used in the research of cancers.
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- CAS No.: 2581824-48-6
- Formule: C29H25N3O4
- Masse moléculaire:479.53
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
MMP-9 5.56 nM (IC50) |
MMP-1 447 nM (IC50) |
MMP-2 221 nM (IC50) |
MMP13 295 nM (IC50) |
AKT 2.11 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
5.7 nM
Compound: 28
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Anticancer activity against human HepG2 cells assessed as reduction in cell viability by MTT assay
Anticancer activity against human HepG2 cells assessed as reduction in cell viability by MTT assay
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[PMID: 31740054] |
| MCF7 | IC50 |
6.6 nM
Compound: 28
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Anticancer activity against human MCF7 cells assessed as reduction in cell viability by MTT assay
Anticancer activity against human MCF7 cells assessed as reduction in cell viability by MTT assay
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[PMID: 31740054] |
| NFS-60 | IC50 |
5.8 nM
Compound: 28
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Anticancer activity against human NFS-60 cells assessed as reduction in cell viability by MTT assay
Anticancer activity against human NFS-60 cells assessed as reduction in cell viability by MTT assay
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[PMID: 31740054] |
| WI-38 | IC50 |
314 nM
Compound: 28
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Cytotoxicity against human WI-38 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against human WI-38 cells assessed as reduction in cell viability by MTT assay
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[PMID: 31740054] |
In Vitro
MMP-9-IN-3 (compound 28, 0-1 μM approximately, 72 h) shows cytotoxicity to Wi-38, MCF-7, NFS-60, HepG-2 cells[1].
MMP-9-IN-3 (72 h) induces apoptosis in MCF-7, NFS-60 and HepG-2 cells at 6.6 nM, 5.8 nM, 5.7 nM respectively[1].
MMP-9-IN-3 (72 h) induces significant caspase 3/7 activation in MCF-7, NFS-60 and HepG-2 cells at 6.6 nM, 5.8 nM, 5.7 nM respectively[1].
MMP-9-IN-3 (5.7 nM, 24 h) inhibits cell migration in HepG-2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Wi-38, MCF-7, NFS-60, HepG-2 cells
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Concentration:0-1 μM approximately
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Incubation Time:72 h
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Result:Showed cytotoxicity with IC50: 314 nM (Wi-38), 6.6 nM (MCF-7), 5.8 nM (NFS-60), 5.7 nM (HepG-2).
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Cell Line:HepG-2
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Concentration:5.7 nM
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Incubation Time:24 h
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Result:Inhibited cell migration by 71.25%.
Chemical Information
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CAS No. 2581824-48-6
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Masse moléculaire 479.53
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Formule C29H25N3O4
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SMILES
O=C(C(N(C(CC1=CC=CC=C1)=O)CC2=CC=CC=C2)C3=CC=CC=C3)NC4=CC=C(C=C4)[N+]([O-])=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MMP-9-IN-3 Related Classifications
HY-146216 Related Classifications
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