1. NF-κB
    Metabolic Enzyme/Protease
    MAPK/ERK Pathway
  2. NF-κB
    MMP
    p38 MAPK
  3. Isoliquiritin apioside

Isoliquiritin apioside 

Cat. No.: HY-N2497
Handling Instructions

Isoliquiritin apioside, a component isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells.

For research use only. We do not sell to patients.

Isoliquiritin apioside Chemical Structure

Isoliquiritin apioside Chemical Structure

CAS No. : 120926-46-7

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Description

Isoliquiritin apioside, a component isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells[1].

IC50 & Target[1]

MMP9

 

NF-κB

 

p38 MAPK

 

In Vitro

Isoliquiritin apioside efficiently suppresses the PMA-induced gelatinolytic MMP-9 activity in HT1080 cells. Isoliquiritin apiosidealso decreases the PMA-induced increase in MMP-9 production in HT1080 cells.Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and endothelial cells (ECs), with no cytotoxicity[1].

Molecular Weight

550.51

Formula

C₂₆H₃₀O₁₃

CAS No.

120926-46-7

SMILES

O=C(C1=C(C=C(O)C=C1)O)/C=C/C(C=C2)=CC=C2O[[email protected]](O[[email protected]](CO)[[email protected]@H](O)[[email protected]@H]3O)[[email protected]]3([H])O[[email protected]]4[[email protected]@H]([[email protected]](CO)(O)CO4)O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Isoliquiritin apiosideNF-κBMMPp38 MAPKNuclear factor-κBNuclear factor-kappaBMatrix metalloproteinasescancermetastasisangiogenesisHT1080HIF-1αMAPKInhibitorinhibitorinhibit

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Isoliquiritin apioside
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