1. NF-κB
    Metabolic Enzyme/Protease
    MAPK/ERK Pathway
  2. NF-κB
    MMP
    p38 MAPK
  3. Isoliquiritin apioside

Isoliquiritin apioside 

Cat. No.: HY-N2497 Purity: 99.87%
Handling Instructions

Isoliquiritin apioside significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells.

For research use only. We do not sell to patients.

Isoliquiritin apioside Chemical Structure

Isoliquiritin apioside Chemical Structure

CAS No. : 120926-46-7

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5 mg USD 215 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Isoliquiritin apioside significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells[1].

IC50 & Target[1]

MMP9

 

NF-κB

 

p38 MAPK

 

In Vitro

Isoliquiritin apioside efficiently suppresses the PMA-induced gelatinolytic MMP-9 activity in HT1080 cells. Isoliquiritin apiosidealso decreases the PMA-induced increase in MMP-9 production in HT1080 cells.Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and endothelial cells (ECs), with no cytotoxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

550.51

Formula

C₂₆H₃₀O₁₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References
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Isoliquiritin apioside
Cat. No.:
HY-N2497
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