BPHA
Based on 1 Customer Validation
BPHA is a potent and orally active MMP-2, MMP-9 and MMP-14 inhibitor with IC50s of 12 nM, 16 nM and 17 nM, respectively. BPHA does not inhibit MMP-1, -3, and -7 (the IC50s are 974, >1000, and 795 nM, respectively). BPHA has antiangiogenic and antitumor effects.
For research use only. We do not sell to patients.
- Purity: 99.88%
- CAS No.: 193807-60-2
- Formula: C21H20N2O4S
- Molecular Weight:396.46
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MMP-2 12 nM (IC50) |
MMP-9 16 nM (IC50) |
MMP-14 17 nM (IC50) |
MMP-1 974 nM (IC50) |
MMP-3 >1000 nM (IC50) |
MMP-7 795 nM (IC50) |
BPHA does not inhibit typical serine proteinases (neutrophil elastase, plasmin, trypsin, and chymotrypsin), cysteine proteinases (cathepsins B and L), aspartic proteinase (HIV-1 protease), or metalloproteinase (aminopeptidase M)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 193807-60-2
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Appearance Solid
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Molecular Weight 396.46
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Formula C21H20N2O4S
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Color White to off-white
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SMILES
O=S(C1=CC=C(C2=CC=CC=C2)C=C1)(N[C@H](CC3=CC=CC=C3)C(NO)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 350 mg/mL (882.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5223 mL | 12.6116 mL | 25.2232 mL | 63.0581 mL |
| 5 mM | 0.5045 mL | 2.5223 mL | 5.0446 mL | 12.6116 mL | |
| 10 mM | 0.2522 mL | 1.2612 mL | 2.5223 mL | 6.3058 mL | |
| 15 mM | 0.1682 mL | 0.8408 mL | 1.6815 mL | 4.2039 mL | |
| 20 mM | 0.1261 mL | 0.6306 mL | 1.2612 mL | 3.1529 mL | |
| 25 mM | 0.1009 mL | 0.5045 mL | 1.0089 mL | 2.5223 mL | |
| 30 mM | 0.0841 mL | 0.4204 mL | 0.8408 mL | 2.1019 mL | |
| 40 mM | 0.0631 mL | 0.3153 mL | 0.6306 mL | 1.5765 mL | |
| 50 mM | 0.0504 mL | 0.2522 mL | 0.5045 mL | 1.2612 mL | |
| 60 mM | 0.0420 mL | 0.2102 mL | 0.4204 mL | 1.0510 mL | |
| 80 mM | 0.0315 mL | 0.1576 mL | 0.3153 mL | 0.7882 mL | |
| 100 mM | 0.0252 mL | 0.1261 mL | 0.2522 mL | 0.6306 mL |
BPHA Related Classifications
HY-114785 Related Classifications
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