2. Protein Tyrosine Kinase/RTK
  3. TAM Receptor
  4. SGI-7079

SGI-7079 

Cat. No.: HY-12964 Purity: 99.59%
COA Handling Instructions

SGI-7079 is a potent and ATP-competitive Axl inhibitor, significantly inhibits the proliferation of SUM149 or KPL-4 cells with an IC50 of 0.43 or 0.16 μM, respectively.

For research use only. We do not sell to patients.

SGI-7079 Chemical Structure

SGI-7079 Chemical Structure

CAS No. : 1239875-86-5

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 119 In-stock
Solution
10 mM * 1 mL in DMSO USD 119 In-stock
Solid
5 mg USD 108 In-stock
10 mg USD 180 In-stock
50 mg USD 660 In-stock
100 mg USD 960 In-stock
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500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 4 publication(s) in Google Scholar

SGI-7079 Related Antibodies

Top Publications Citing Use of Products

    SGI-7079 purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2023 Jan 18;188:106668.  [Abstract]

    SGI-7079 (1 μM; 24 h) effectively inhibits AXL activation in HCC827/OR and H1975/OR cells.

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    • References

    • Customer Review

    Description

    SGI-7079 is a potent and ATP-competitive Axl inhibitor, significantly inhibits the proliferation of SUM149 or KPL-4 cells with an IC50 of 0.43 or 0.16 μM, respectively.

    Molecular Weight

    455.53

    Appearance

    Solid

    Formula

    C26H26FN7
    CAS No.
    SMILES

    N#CCC1=CC=CC(C2=C3C(NC=C3C)=NC(NC4=CC=C(N5CCN(C)CC5)C(F)=C4)=N2)=C1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 34 mg/mL (74.64 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1952 mL 10.9762 mL 21.9525 mL
    5 mM 0.4390 mL 2.1952 mL 4.3905 mL
    10 mM 0.2195 mL 1.0976 mL 2.1952 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.17 mg/mL (4.76 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.17 mg/mL (4.76 mM); Clear solution

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.59%

    COA (252 KB) LCMS (269 KB)

    Handling Instructions (2659 KB)
    References
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    SGI-7079 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    SGI-70791239875-86-5SGI7079SGI 7079TAM ReceptorTyro3AxlMerInhibitorinhibitorinhibit

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