1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. DL-Mevalonolactone

DL-Mevalonolactone (Synonyms: (±)-Mevalonolactone; Mevalolactone)

Cat. No.: HY-107855 Purity: >98.0%
Handling Instructions

DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (∆Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling.

For research use only. We do not sell to patients.

DL-Mevalonolactone Chemical Structure

DL-Mevalonolactone Chemical Structure

CAS No. : 674-26-0

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 149 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 135 In-stock
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100 mg USD 230 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (∆Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2].

IC50 & Target

Human Endogenous Metabolite

 

Molecular Weight

130.14

Formula

C₆H₁₀O₃

CAS No.

674-26-0

SMILES

O=C1CC(C)(O)CCO1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1921.01 mM; Need ultrasonic)

H2O : 50 mg/mL (384.20 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.6840 mL 38.4202 mL 76.8403 mL
5 mM 1.5368 mL 7.6840 mL 15.3681 mL
10 mM 0.7684 mL 3.8420 mL 7.6840 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (15.98 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (15.98 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (15.98 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DL-Mevalonolactone(±)-MevalonolactoneMevalolactoneEndogenous MetaboliteInhibitorinhibitorinhibit

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Product Name:
DL-Mevalonolactone
Cat. No.:
HY-107855
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